ID A0A3Q4HH45_NEOBR Unreviewed; 1016 AA.
AC A0A3Q4HH45;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 28-JAN-2026, entry version 34.
DE RecName: Full=Signal peptide, CUB and EGF-like domain-containing protein 2 {ECO:0000256|ARBA:ARBA00067359};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000016337.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000016337.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSNBRP00000016337.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell surface {ECO:0000256|ARBA:ARBA00004241}.
CC Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A3Q4HH45; -.
DR STRING; 32507.ENSNBRP00000016337; -.
DR Ensembl; ENSNBRT00000016774.1; ENSNBRP00000016337.1; ENSNBRG00000012484.1.
DR GeneTree; ENSGT00940000153185; -.
DR Proteomes; UP000261580; Unassembled WGS sequence.
DR Bgee; ENSNBRG00000012484; Expressed in liver and 4 other cell types or tissues.
DR GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:TreeGrafter.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 3.
DR FunFam; 2.10.25.10:FF:000032; signal peptide, CUB and EGF-like domain-containing protein 2 isoform X1; 1.
DR FunFam; 2.10.50.10:FF:000002; signal peptide, CUB and EGF-like domain-containing protein 2 isoform X1; 1.
DR FunFam; 2.10.25.10:FF:000199; signal peptide, CUB and EGF-like domain-containing protein 2 isoform X2; 1.
DR FunFam; 2.10.25.10:FF:000256; Signal peptide, CUB domain and EGF like domain containing 2; 1.
DR FunFam; 2.10.50.10:FF:000029; Signal peptide, CUB domain and EGF like domain containing 2; 1.
DR FunFam; 2.10.25.10:FF:000028; Signal peptide, CUB domain and EGF-like domain-containing 2; 1.
DR FunFam; 2.10.25.10:FF:000030; Signal peptide, CUB domain and EGF-like domain-containing 2; 1.
DR FunFam; 2.10.25.10:FF:000035; Signal peptide, CUB domain and EGF-like domain-containing 2; 1.
DR FunFam; 2.60.120.290:FF:000002; Signal peptide, CUB domain and EGF-like domain-containing 2; 1.
DR FunFam; 2.10.25.10:FF:000008; Signal peptide, CUB domain, EGF-like 2; 2.
DR FunFam; 2.10.25.10:FF:000240; Vitamin K-dependent protein S; 1.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR000742; EGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR024731; NELL2-like_EGF.
DR InterPro; IPR049883; NOTCH1_EGF-like.
DR InterPro; IPR052071; SCUB_EGF-like_domain.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF3; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF12662; cEGF; 2.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF14670; FXa_inhibition; 3.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM01411; Ephrin_rec_like; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 5.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 5.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1016
FT /note="Signal peptide, CUB and EGF-like domain-containing
FT protein 2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018554562"
FT DOMAIN 28..68
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 111..147
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 306..346
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 347..385
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 828..940
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 351..361
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1016 AA; 112977 MW; BBC3E360E55F2FD6 CRC64;
MGAVWAARDF CLFLLLLNSR QSAALPEFRD PCAEGSDGCH IDAICQTTQD SYKCTCKAGF
KGDGKQCEDI DECDLEYNGG CVHECNNTPG NYRCTCYDGF HLAHDGHNCL DVDECQFNNG
GCQHTCVNTM GSYECRCKEG FFLSDNQHTC IHRSVEGLNC MNKEHGCAHI CKETSKGGVA
CECRPGFELA KNQRDCILTC NHGNGGCQHT CEDTENGSIC RCHSRYTLQP DRSSCVERDE
ATTESLDHNA TSFTEVDKRV KRRLLMETCA VNNGGCDCTC KDTSTGVRCS CPAGFTLQPD
GKTCKDIDEC EVNNGGCDHS CKNTIGSFEC NCRKGFKLLT DERSCQDIDE CFFERTCDHT
CVNSPGGFQC LCNKGYTMYG LAHCGDINEC SVNNAGCEHG CENTVGGFEC FCRPGYKLHW
NKKDCIAAQG LSPAQPPSKP TLNCSKQEGG DRCFLTCQSQ VHISSGTEDS YTVTCGMPLP
CLADAQKNNS GSYCLGNLAR IKTTATFKSG TARCNLKRSQ EKLRESLNSA RSERKFLFTE
NVQFSYVSLH CTSSGQRMRS RHGRKAGEED GSSITAEFEL DVNLEEVTAE GCDVNCVRRR
SEKRLRKTIR TLRKSINREQ FHLHFAGADY NLSRSPGQLA ELPGHCVAGQ MFLGRKCVSC
GVGTYYDGDQ GRCLSCPAGT YQDEEGQMSC EVCPTPQGRE VSKVVGARNI SECGGQCSPG
QYSHDGFIPC LLCPPGTYQP EVGRTSCFPC GGDLDTRRSA AVSFQECETK VQCSPGHYYN
TSTHRCIRCP MGTYQGDFGQ NYCVTCPGNT TTDYDGSTNI MQCKNRRCGG ELGDFTGYIE
SPNYPGNYPA NIECTWIINP PPKRRILIVV PEIYLPIEDE CGDYLVMRKS SLPNSVTTYE
TCQTYERPIA FTSRSKRLWI QFRSNEGNSG KGFQVPYVTY DEDYQELIED IVRDGRLYAS
EHHQEILKDK KLMKALFDVL AHPQNFFNYT AQESREMFPK SFIRFLRSKV LRFLRP
//
