ID A0A3Q4HR77_NEOBR Unreviewed; 469 AA.
AC A0A3Q4HR77;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 18-JUN-2025, entry version 32.
DE SubName: Full=Regulator of G protein signaling 7a {ECO:0000313|Ensembl:ENSNBRP00000019892.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000019892.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000019892.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
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DR AlphaFoldDB; A0A3Q4HR77; -.
DR STRING; 32507.ENSNBRP00000019892; -.
DR Ensembl; ENSNBRT00000020421.1; ENSNBRP00000019892.1; ENSNBRG00000015309.1.
DR GeneTree; ENSGT00940000156661; -.
DR OMA; YVEYDPC; -.
DR Proteomes; UP000261580; Unassembled WGS sequence.
DR Bgee; ENSNBRG00000015309; Expressed in brain and 3 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0043005; C:neuron projection; IEA:TreeGrafter.
DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR GO; GO:0005096; F:GTPase activator activity; IEA:TreeGrafter.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR CDD; cd04450; DEP_RGS7-like; 1.
DR CDD; cd00068; GGL; 1.
DR CDD; cd08738; RGS_RGS7; 1.
DR FunFam; 1.10.10.10:FF:000162; Regulator of G-protein signaling 6; 1.
DR FunFam; 1.10.1240.60:FF:000001; Regulator of G-protein signaling 6; 1.
DR FunFam; 4.10.260.10:FF:000002; Regulator of G-protein signaling 6; 1.
DR FunFam; 1.10.167.10:FF:000002; Regulator of G-protein signaling 6 isoform 9; 1.
DR Gene3D; 1.10.1240.60; -; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR Gene3D; 4.10.260.10; Transducin (heterotrimeric G protein), gamma chain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR015898; G-protein_gamma-like_dom.
DR InterPro; IPR036284; GGL_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR047016; RGS6/7/9/11.
DR InterPro; IPR047017; RGS6/7/9/11_DHEX_sf.
DR InterPro; IPR040759; RGS_DHEX.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45746; LP21163P; 1.
DR PANTHER; PTHR45746:SF7; REGULATOR OF G-PROTEIN SIGNALING 7; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00631; G-gamma; 1.
DR Pfam; PF00615; RGS; 1.
DR Pfam; PF18148; RGS_DHEX; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00049; DEP; 1.
DR SMART; SM01224; G_gamma; 1.
DR SMART; SM00224; GGL; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF48670; Transducin (heterotrimeric G protein), gamma chain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700}.
FT DOMAIN 37..112
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 333..448
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
SQ SEQUENCE 469 AA; 54460 MW; 42617DF1C2713F08 CRC64;
MAQTNSSGQG TNGVADESPN MIVYRKMEEV IARMQDEKNG IPIRTVKSFL TKIPSVFSGS
DIVQWMMKNL DIEDQVEALH LGTLMAAHGY FFPISDHVLT LKDDGTFYRF QTPYFWPSNC
WEPENTDYAV YLCKRTMQNK ARLELADYEA ESLARLQRAF ARKWEFIFMQ AEAQAKVDKK
RDKIERKILD SQERAFWDVH RPVPGCVNTT EVDIKKSSRM KNPHKTRKSV YGLQNDIRTH
SPTHTPAPEA KQPTEEELQE QITFWQLQLD RHRLKMSKVA ESLLGYTEQY LEYDPFLTPP
DPSNPWISDD TTLWELEASK EPGQQRVKRW AFGIDEVLKD PVGREQFLKF LESEFSSENL
RFWLAVQELK KRPIREVPTR VQEIWQEFLA PGAPSAINVD SKSYDKTTQN VKDPGRYAFE
DAQEHIYKLM KSDSYSRFIR SSAYQELLQA KKKGKPLASK RLTSCVPSC
//
