ID A0A3Q4HYP9_NEOBR Unreviewed; 499 AA.
AC A0A3Q4HYP9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 28-JAN-2026, entry version 35.
DE RecName: Full=Histone acetyltransferase KAT5 {ECO:0000256|ARBA:ARBA00073520};
DE EC=2.3.1.48 {ECO:0000256|ARBA:ARBA00013184};
DE AltName: Full=60 kDa Tat-interactive protein {ECO:0000256|ARBA:ARBA00075576};
DE AltName: Full=Histone acetyltransferase HTATIP {ECO:0000256|ARBA:ARBA00078544};
DE AltName: Full=Lysine acetyltransferase 5 {ECO:0000256|ARBA:ARBA00081819};
DE AltName: Full=Protein 2-hydroxyisobutyryltransferase KAT5 {ECO:0000256|ARBA:ARBA00076578};
DE AltName: Full=Protein acetyltransferase KAT5 {ECO:0000256|ARBA:ARBA00076154};
DE AltName: Full=Protein crotonyltransferase KAT5 {ECO:0000256|ARBA:ARBA00078969};
DE AltName: Full=Protein lactyltransferase KAT5 {ECO:0000256|ARBA:ARBA00077013};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000027386.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000027386.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSNBRP00000027386.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2E)-butenoyl-CoA + L-lysyl-[protein] = N(6)-(2E)-butenoyl-L-
CC lysyl-[protein] + CoA + H(+); Xref=Rhea:RHEA:53908, Rhea:RHEA-
CC COMP:9752, Rhea:RHEA-COMP:13707, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57332,
CC ChEBI:CHEBI:137954; Evidence={ECO:0000256|ARBA:ARBA00047752};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53909;
CC Evidence={ECO:0000256|ARBA:ARBA00047752};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-lactoyl-CoA + L-lysyl-[protein] = N(6)-[(S)-lactoyl]-L-
CC lysyl-[protein] + CoA + H(+); Xref=Rhea:RHEA:61996, Rhea:RHEA-
CC COMP:9752, Rhea:RHEA-COMP:19466, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:231527,
CC ChEBI:CHEBI:231528; Evidence={ECO:0000256|ARBA:ARBA00047411};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61997;
CC Evidence={ECO:0000256|ARBA:ARBA00047411};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = N(6)-(2-
CC hydroxyisobutanoyl)-L-lysyl-[protein] + CoA + H(+);
CC Xref=Rhea:RHEA:24180, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:15921,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:131780, ChEBI:CHEBI:144968;
CC Evidence={ECO:0000256|ARBA:ARBA00047557};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24181;
CC Evidence={ECO:0000256|ARBA:ARBA00047557};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone]
CC + CoA + H(+); Xref=Rhea:RHEA:21992, Rhea:RHEA-COMP:9845, Rhea:RHEA-
CC COMP:11338, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48;
CC Evidence={ECO:0000256|ARBA:ARBA00048940};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21993;
CC Evidence={ECO:0000256|ARBA:ARBA00048940};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MYST (SAS/MOZ) family.
CC {ECO:0000256|ARBA:ARBA00010107}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3Q4HYP9; -.
DR Ensembl; ENSNBRT00000028103.1; ENSNBRP00000027386.1; ENSNBRG00000020811.1.
DR GeneTree; ENSGT00940000162343; -.
DR Proteomes; UP000261580; Unassembled WGS sequence.
DR Bgee; ENSNBRG00000020811; Expressed in mesonephros and 9 other cell types or tissues.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IEA:TreeGrafter.
DR GO; GO:0031981; C:nuclear lumen; IEA:UniProtKB-ARBA.
DR GO; GO:0003682; F:chromatin binding; IEA:UniProtKB-ARBA.
DR GO; GO:0046972; F:histone H4K16 acetyltransferase activity; IEA:TreeGrafter.
DR GO; GO:0106226; F:peptide 2-hydroxyisobutyryltransferase activity; IEA:RHEA.
DR GO; GO:0140064; F:peptide crotonyltransferase activity; IEA:RHEA.
DR GO; GO:0120300; F:peptide lactyltransferase (CoA-dependent) activity; IEA:RHEA.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:1901701; P:cellular response to oxygen-containing compound; IEA:UniProtKB-ARBA.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:TreeGrafter.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:UniProtKB-ARBA.
DR FunFam; 1.10.10.10:FF:000022; Histone acetyltransferase; 1.
DR FunFam; 2.30.30.140:FF:000013; Histone acetyltransferase; 1.
DR FunFam; 3.30.60.60:FF:000001; Histone acetyltransferase; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 3.40.630.30; -; 2.
DR Gene3D; 3.30.60.60; N-acetyl transferase-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR002717; HAT_MYST-type.
DR InterPro; IPR050603; MYST_HAT.
DR InterPro; IPR025995; Tudor-knot.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR040706; Zf-MYST.
DR PANTHER; PTHR10615; HISTONE ACETYLTRANSFERASE; 1.
DR PANTHER; PTHR10615:SF219; HISTONE ACETYLTRANSFERASE KAT5; 1.
DR Pfam; PF01853; MOZ_SAS; 1.
DR Pfam; PF11717; Tudor-knot; 1.
DR Pfam; PF17772; zf-MYST; 1.
DR SMART; SM00298; CHROMO; 1.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR PROSITE; PS51726; MYST_HAT; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 254..490
FT /note="MYST-type HAT"
FT /evidence="ECO:0000259|PROSITE:PS51726"
FT REGION 70..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 221..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..106
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 389
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
SQ SEQUENCE 499 AA; 57335 MW; 7FBFCCB326AF494B CRC64;
LTQPAVEIVE GCRLPVLRKN QEHEDEWPLA EILSVKEVSG RKLYYVHYID FNKRLDEWVT
TERLDMKKLQ FPKKDAKTPT KNGLSGSRPS SPERERDRER EREKSLDLNV QTATAPSRGK
TLPTPKRKVE PAPVAPQVPP VIPVPSLPSS AEATQAAVFP AVRETPTFKS REDHELTTNG
NARRLIPAPP GRKRKANCGG TDEMIKVLQY NKPQSASVFL PPPEDSQDSS DGIPTAPRMT
GSLVSDRSHD DIVTRMKNIE CIELGRHRLK PWYFSPYPQE LTSLPILYLC EFCLKYLKSL
KCLQRHLTKC NLRHPPGNEI YRKGTISFFE IDGRKNKNYS QNLCLLAKCF LDHKTLYYDT
DPFLFYVMTE YDSKGYELSK VEGKTGTPEK PLSDLGLLSY RSYWSQTILE ILMDLKPDNG
ERPQITINEI SEITSVKKED VISTLQYLNL INYYKGQYIL TLSEDIVEGH ERAMQKRHLR
IDPKCLHFTP KDWSKRGKW
//
