ID A0A3Q4M5R3_NEOBR Unreviewed; 237 AA.
AC A0A3Q4M5R3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 28-JAN-2026, entry version 34.
DE SubName: Full=Hes family bHLH transcription factor 6 {ECO:0000313|Ensembl:ENSNBRP00000002919.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000002919.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000002919.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSNBRP00000002919.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_006801207.1; XM_006801144.1.
DR AlphaFoldDB; A0A3Q4M5R3; -.
DR STRING; 32507.ENSNBRP00000002919; -.
DR Ensembl; ENSNBRT00000003026.1; ENSNBRP00000002919.1; ENSNBRG00000002345.1.
DR GeneID; 102792702; -.
DR GeneTree; ENSGT00940000161398; -.
DR OMA; EDESCYG; -.
DR OrthoDB; 6085656at2759; -.
DR Proteomes; UP000261580; Unassembled WGS sequence.
DR Bgee; ENSNBRG00000002345; Expressed in brain and 1 other cell type or tissue.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd11460; bHLH-O_HES6; 1.
DR FunFam; 4.10.280.10:FF:000112; Hes family bHLH transcription factor 6; 1.
DR Gene3D; 6.10.250.980; -; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR050370; HES_HEY.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR PANTHER; PTHR10985; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED; 1.
DR Pfam; PF07527; Hairy_orange; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00511; ORANGE; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF158457; Orange domain-like; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 28..80
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 99..132
FT /note="Orange"
FT /evidence="ECO:0000259|PROSITE:PS51054"
FT REGION 178..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 67..98
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 178..194
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 237 AA; 26413 MW; 43AD71823AEA60B8 CRC64;
MAPSARPNGL GLDVKDEDES YCGIQKADRK TRKPLVEKKR RARINESLQE LRTLLADTDF
HSKMENAEVL ELTVKKVEDI LKNRKQEAET LNREANERFA AGYIQCMHEV HMFVSSCPGI
DATVAAELLN HLLECMPLNE DHLQDMLTDL ITDTSEGNSR GSEALCASLA SPGERSFSCG
SSSALSPAPS SMSSEDLCSD LDETDSDHNQ SSTEGMENRE PPSMPTMTYP WSMWRPW
//
