ID   A0A3Q4MX50_NEOBR        Unreviewed;       313 AA.
AC   A0A3Q4MX50;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   28-JAN-2026, entry version 33.
DE   SubName: Full=Forkhead box L1 {ECO:0000313|Ensembl:ENSNBRP00000021564.1};
OS   Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX   NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000021564.1, ECO:0000313|Proteomes:UP000261580};
RN   [1] {ECO:0000313|Ensembl:ENSNBRP00000021564.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2025) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSNBRP00000021564.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2025) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00089}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3Q4MX50; -.
DR   STRING; 32507.ENSNBRP00000021564; -.
DR   Ensembl; ENSNBRT00000022145.1; ENSNBRP00000021564.1; ENSNBRG00000016546.1.
DR   GeneTree; ENSGT00940000162251; -.
DR   OMA; HMGFPLC; -.
DR   Proteomes; UP000261580; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:TreeGrafter.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IEA:TreeGrafter.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-ARBA.
DR   GO; GO:0009888; P:tissue development; IEA:UniProtKB-ARBA.
DR   CDD; cd20027; FH_FOXL1; 1.
DR   FunFam; 1.10.10.10:FF:000016; Forkhead box protein I1; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR047514; FH_FOXL1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR050211; FOX_domain-containing.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11829; FORKHEAD BOX PROTEIN; 1.
DR   PANTHER; PTHR11829:SF204; FORKHEAD BOX PROTEIN L1; 1.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00089};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00089}; Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          53..147
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000259|PROSITE:PS50039"
FT   DNA_BIND        53..147
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT   REGION          144..207
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          221..240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        195..207
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        229..240
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   313 AA;  34492 MW;  B89E86890ACAC35D CRC64;
     MTLYHGRLPS LGVTSSALSL SAPPLIYLYG GDSGGVVPTA LSFVPARQEP PQKPPYSYIA
     LIAMAIKSAP EQRATLSGIY QFIMDRFPFY HDNKQGWQNS IRHNLSLNDC FIKVPREKGR
     PGKGSYWTLD TKCLDMFENG NYRRRKRKAK CQQEALDSKA TGHKRTKAPG QPRDPQTSPK
     HQAGSRVTEA PTLDPKSEER KSAFSQRERG PLCTVSCAGN TNLAAPAPDR PKGNTLSRDK
     SKGFSIDSIL AKSEDEIRGS ILGLPAETCA QGQNPAFSAS VVLGARQHQL YQMGFPFCSY
     LSLSYPDKVL HFK
//