ID   A0A3Q4N2H6_NEOBR        Unreviewed;       563 AA.
AC   A0A3Q4N2H6;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   28-JAN-2026, entry version 33.
DE   SubName: Full=Suppressor of cytokine signaling 5b {ECO:0000313|Ensembl:ENSNBRP00000025274.1};
OS   Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX   NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000025274.1, ECO:0000313|Proteomes:UP000261580};
RN   [1] {ECO:0000313|Ensembl:ENSNBRP00000025274.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2025) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSNBRP00000025274.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2025) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
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DR   RefSeq; XP_006799136.1; XM_006799073.2.
DR   AlphaFoldDB; A0A3Q4N2H6; -.
DR   STRING; 32507.ENSNBRP00000025274; -.
DR   Ensembl; ENSNBRT00000025931.1; ENSNBRP00000025274.1; ENSNBRG00000019321.1.
DR   GeneID; 102792288; -.
DR   CTD; 559639; -.
DR   GeneTree; ENSGT00940000164285; -.
DR   OMA; CQNLFNH; -.
DR   OrthoDB; 8820570at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000261580; Unassembled WGS sequence.
DR   Bgee; ENSNBRG00000019321; Expressed in blood and 8 other cell types or tissues.
DR   GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR   GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR022252; SOCS4/SOCS5_dom.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF12610; SOCS; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00253; SOCS; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   SUPFAM; SSF158235; SOCS box-like; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   4: Predicted;
KW   Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191};
KW   Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          407..502
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          497..546
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000259|PROSITE:PS50225"
FT   REGION          96..155
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          361..381
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   563 AA;  61993 MW;  0FFF2DD77CD9A99F CRC64;
     MKKVGIMWSN LKSRCQTLFH NNSSGPHESR IEADTVHCVV DIGQGGSSGG AQASGASSPS
     RSLLPVPVVT AGRRHHNCVS DIPQIVEITI DKDAEDVRGG SGGVPLARRD SYSRHAPWGG
     KKKHSCSTKT QSSLEADRRS GRLRGSGNRR DRRYGVSSIQ ETNDSVSVGR SLNGRSLRQR
     LSDTVGLCLP LPARRCSRSS KNAVTSKRKI HLTELMLETC PFPPGSDLAH KWHLIKQHTA
     PVSPHSSTAL LDAFDPAHPS PEDEEERLRE RRRLSIEEGV DPPPNAQIHT LEASVPGSSL
     YKLGPKMAPG MGEASGEGRV TGAGSALAAA SSGACGQLLG AAASSQDCDS EEDSTTLCLQ
     ARRPKQRHAS GDGHLSRQQP GPWKVHTQID YIHCLVPDLL EITGLPCYWG VMDRYEAEAL
     LDGRPEGTFL LRDSAQEDYL FSVSFRRYNR SLHARIEQWN HNFSFDAHDP CVFHSSTVTG
     LLEHYKDPSA CMFFEPLLTA PLHRTFPFGL QHLARAAICR WTTYDGIGSL PLPPALQDFL
     KEYHYKQKVR VRWLEREPPL KVK
//