ID A0A3Q7Q1Y8_CALUR Unreviewed; 420 AA.
AC A0A3Q7Q1Y8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 28-JAN-2026, entry version 28.
DE RecName: Full=Dynein axonemal assembly factor 4 {ECO:0000256|ARBA:ARBA00024430};
GN Name=DNAAF4 {ECO:0000313|RefSeq:XP_025739958.1};
OS Callorhinus ursinus (Northern fur seal).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Otariidae;
OC Callorhinus.
OX NCBI_TaxID=34884 {ECO:0000313|Proteomes:UP000286641, ECO:0000313|RefSeq:XP_025739958.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025739958.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025739958.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, neuron projection
CC {ECO:0000256|ARBA:ARBA00004487}. Dynein axonemal particle
CC {ECO:0000256|ARBA:ARBA00024190}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_025739958.1; XM_025884173.1.
DR AlphaFoldDB; A0A3Q7Q1Y8; -.
DR GeneID; 112833170; -.
DR CTD; 161582; -.
DR InParanoid; A0A3Q7Q1Y8; -.
DR Proteomes; UP000286641; Unplaced.
DR GO; GO:0120293; C:dynein axonemal particle; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:GOC.
DR GO; GO:0043005; C:neuron projection; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0030331; F:nuclear estrogen receptor binding; IEA:TreeGrafter.
DR GO; GO:0007368; P:determination of left/right symmetry; IEA:TreeGrafter.
DR GO; GO:0003351; P:epithelial cilium movement involved in extracellular fluid movement; IEA:TreeGrafter.
DR GO; GO:0007507; P:heart development; IEA:TreeGrafter.
DR GO; GO:0036159; P:inner dynein arm assembly; IEA:TreeGrafter.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0036158; P:outer dynein arm assembly; IEA:TreeGrafter.
DR CDD; cd06469; p23_DYX1C1_like; 1.
DR FunFam; 1.25.40.10:FF:000176; dynein assembly factor 4, axonemal isoform X1; 1.
DR FunFam; 2.60.40.790:FF:000015; dynein assembly factor 4, axonemal isoform X1; 1.
DR Gene3D; 2.60.40.790; -; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR007052; CS_dom.
DR InterPro; IPR037894; CS_DYX1C1.
DR InterPro; IPR052004; Dynein_assembly_factor_4.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_rpt.
DR PANTHER; PTHR46492; DYNEIN ASSEMBLY FACTOR 4, AXONEMAL; 1.
DR PANTHER; PTHR46492:SF1; DYNEIN AXONEMAL ASSEMBLY FACTOR 4; 1.
DR Pfam; PF04969; CS; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF49764; HSP20-like chaperones; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51203; CS; 1.
DR PROSITE; PS50005; TPR; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000286641};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT DOMAIN 3..87
FT /note="CS"
FT /evidence="ECO:0000259|PROSITE:PS51203"
FT REPEAT 366..399
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT COILED 104..156
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 420 AA; 48577 MW; EA3E061B708AE04E CRC64;
MPLQVSDYTW QQTKTAVFIS VPLRGVCVRD ADVFCTENYL KVNFYPFLFE VFLYAPIDDE
NSKAKIGNDT IAFTLYKKEV AMWETLSVSG VDKEMMQRIR EKSILQAQER AKEAAEAKAA
ARREDQKYAL NVMMKIEEEE RKKIEDMKEN ERLKATKELE AWKECQRKAE EQKRIQREEK
FCEQGKQTEE ERNKLKHKSL TRIAASRNLA TKGRNSENIF LEKLKQDSIP APRSVGSIKI
NFTPRVFPTA LRESQVAEEE EWLHKQAEAR RALNTDIPEL SDLKEEEKNP EWLKDKGNKL
FAKENYLAAI NAYNLAIRLN NKIPLLYLNR AACHLKLKNL HKAIEDSSKA LELLTPPVAD
NANGRMKAYI RRGTAFCQLE LYIEGLQDYE AALKIDPSNK IVQNDAEKIR KIIQGTELKS
//
