ID A0A3Q7SRF3_VULVU Unreviewed; 743 AA.
AC A0A3Q7SRF3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 28-JAN-2026, entry version 32.
DE RecName: Full=YTH domain-containing family protein {ECO:0000256|RuleBase:RU369095};
GN Name=YTHDC1 {ECO:0000313|RefSeq:XP_025859313.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP001652641, ECO:0000313|RefSeq:XP_025859313.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|Proteomes:UP001652641}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG RefSeq;
RL Submitted (MAY-2025) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_025859313.1}
RP IDENTIFICATION.
RC TISSUE=Cell line {ECO:0000313|RefSeq:XP_025859313.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- FUNCTION: Specifically recognizes and binds N6-methyladenosine (m6A)-
CC containing RNAs, and regulates mRNA stability. M6A is a modification
CC present at internal sites of mRNAs and some non-coding RNAs and plays a
CC role in mRNA stability and processing. {ECO:0000256|RuleBase:RU369095}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the YTHDF family.
CC {ECO:0000256|RuleBase:RU369095}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_025859313.1; XM_026003528.2.
DR AlphaFoldDB; A0A3Q7SRF3; -.
DR GeneID; 112923694; -.
DR KEGG; vvp:112923694; -.
DR CTD; 91746; -.
DR Proteomes; UP001652641; Chromosome 2.
DR GO; GO:0005654; C:nucleoplasm; IEA:TreeGrafter.
DR GO; GO:0003729; F:mRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:1990247; F:N6-methyladenosine-containing RNA reader activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:TreeGrafter.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IEA:TreeGrafter.
DR CDD; cd21134; YTH; 1.
DR FunFam; 3.10.590.10:FF:000002; YTH domain-containing protein 1 isoform X1; 1.
DR Gene3D; 3.10.590.10; ph1033 like domains; 1.
DR InterPro; IPR007275; YTH_domain.
DR InterPro; IPR045168; YTH_prot.
DR PANTHER; PTHR12357:SF3; YTH DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR12357; YTH YT521-B HOMOLOGY DOMAIN-CONTAINING; 1.
DR Pfam; PF04146; YTH; 1.
DR PROSITE; PS50882; YTH; 1.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP001652641};
KW RNA-binding {ECO:0000256|RuleBase:RU369095}.
FT DOMAIN 363..500
FT /note="YTH"
FT /evidence="ECO:0000259|PROSITE:PS50882"
FT REGION 28..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 623..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 685..743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..119
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..148
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..168
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..190
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..262
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..278
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..297
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..333
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..531
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 532..557
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 695..743
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 743 AA; 86579 MW; 8985C68EB04699A9 CRC64;
MSCALKYRLP RPTDGELNVL DDILTEVPEQ DDELYNPESE QDKNEKKGSK RKSDRMESTD
IKRQKPSVHS RQLISKPLSS SVSNNKRIVS TKGKSVGEYK NEEYQRSERS KRLEADRKIR
LSSSASREPY KSQPEKTCLR KRDPERRTKS PTPDGSEVRI GLEVDRRASR SSQSSKEEVN
SEEYGSDHET GSSGSSDEQG NNTENEEEGV EDVEEDEEVE EDAEEDEEVD EDGEEEEEEE
EEEEEEEEEE EEEEEEEYEQ DERDQKEEGN DYDTRSEASD SDSESVSFTD GSVRSGSGTD
GSDEKKKERK RARGISPIVF DRSGSSASES YAGSEKKHEK LSSSVRAVRK DQTSKLKYVL
QDARFFLIKS NNHENVSLAK AKGVWSTLPV NEKKLNAAFR SARSVILIFS VRESGKFQGF
ARLSSESHHG GSPIHWVLPA GMNAKMLGGV FKIDWICRRE LPFTKSAHLT NPWNEHKPVK
IGRDGQEIEL ECGTQLCLLF PPDESIDLYQ VIHKMRHKRR MHSQPRSRGR PSRREPVRDV
GRRRPEDYDI HNSRKKPRID YAPEFHQRPG YLKDPRYQEV DSFTNLIPNR RFSGVRRDVF
LNGSYNDYVR EFHNMGPPPP WQGMAPYPGM EQPPHHPYYQ HHAPPPQAHP PYSGHHPVPH
EARYRDKRVH DYDMRVDDFL RRTQAVVSGR RSRPRERDRE RERDRPRDNR RDRERDRGRD
RERERERLCD RDRDRGERGR YRR
//
