UniProt: A0A3Q7TB43

Database: UniProt
Entry: A0A3Q7TB43_VULVU

LinkDB:  A0A3Q7TB43_VULVU 
Original site:  A0A3Q7TB43_VULVU

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Ontology (35)   
   GO (35)   
Gene (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (22)   
   InterPro (14)   
   Pfam (6)   
   PROSITE (1)   
   SMART (1)   
All databases (59)   

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ID   A0A3Q7TB43_VULVU        Unreviewed;       750 AA.
AC   A0A3Q7TB43;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   18-JUN-2025, entry version 29.
DE   RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
GN   Name=STAT1 {ECO:0000313|RefSeq:XP_025858432.1};
OS   Vulpes vulpes (Red fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX   NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025858432.1};
RN   [1]
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (JAN-2019) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_025858432.1}
RP   IDENTIFICATION.
RC   STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025858432.1};
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_025858432.1};
RG   RefSeq;
RL   Submitted (MAR-2025) to UniProtKB.
CC   -!- SUBUNIT: (Microbial infection) Interacts with African swine fever virus
CC       (ASFV) MGF360-9L; this interaction mediates degradation of STAT1
CC       through apoptosis. {ECO:0000256|ARBA:ARBA00064572}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC       ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU046415}.
CC   -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC       {ECO:0000256|ARBA:ARBA00005586, ECO:0000256|RuleBase:RU046415}.
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DR   RefSeq; XP_025858432.1; XM_026002647.1.
DR   AlphaFoldDB; A0A3Q7TB43; -.
DR   SMR; A0A3Q7TB43; -.
DR   STRING; 9627.ENSVVUP00000036916; -.
DR   GeneID; 112922923; -.
DR   OMA; FDTMMNA; -.
DR   Proteomes; UP000286640; Unplaced.
DR   GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0070721; C:ISGF3 complex; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0035035; F:histone acetyltransferase binding; IEA:Ensembl.
DR   GO; GO:0042393; F:histone binding; IEA:Ensembl.
DR   GO; GO:1990841; F:promoter-specific chromatin binding; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0001223; F:transcription coactivator binding; IEA:Ensembl.
DR   GO; GO:0001222; F:transcription corepressor binding; IEA:Ensembl.
DR   GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:Ensembl.
DR   GO; GO:0044389; F:ubiquitin-like protein ligase binding; IEA:Ensembl.
DR   GO; GO:0007259; P:cell surface receptor signaling pathway via JAK-STAT; IEA:Ensembl.
DR   GO; GO:0035458; P:cellular response to interferon-beta; IEA:Ensembl.
DR   GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR   GO; GO:0070106; P:interleukin-27-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0038111; P:interleukin-7-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0038113; P:interleukin-9-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0046725; P:negative regulation by virus of viral protein levels in host cell; IEA:Ensembl.
DR   GO; GO:0016525; P:negative regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0043124; P:negative regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR   GO; GO:0001937; P:negative regulation of endothelial cell proliferation; IEA:Ensembl.
DR   GO; GO:0002230; P:positive regulation of defense response to virus by host; IEA:Ensembl.
DR   GO; GO:0045648; P:positive regulation of erythrocyte differentiation; IEA:Ensembl.
DR   GO; GO:0032727; P:positive regulation of interferon-alpha production; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0061326; P:renal tubule development; IEA:Ensembl.
DR   GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0060337; P:type I interferon-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0060333; P:type II interferon-mediated signaling pathway; IEA:Ensembl.
DR   CDD; cd10372; SH2_STAT1; 1.
DR   CDD; cd16851; STAT1_CCD; 1.
DR   CDD; cd16845; STAT1_DBD; 1.
DR   FunFam; 1.10.238.10:FF:000012; Signal transducer and activator of transcription; 1.
DR   FunFam; 1.10.532.10:FF:000001; Signal transducer and activator of transcription; 1.
DR   FunFam; 1.20.1050.20:FF:000001; Signal transducer and activator of transcription; 1.
DR   FunFam; 2.60.40.630:FF:000001; Signal transducer and activator of transcription; 1.
DR   FunFam; 3.30.505.10:FF:000003; Signal transducer and activator of transcription; 1.
DR   FunFam; 6.10.250.3310:FF:000001; Signal transducer and activator of transcription; 1.
DR   Gene3D; 1.10.238.10; EF-hand; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   Gene3D; 6.10.250.3310; signal transducer and activator of transcription 1; 1.
DR   Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 1.
DR   Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 1.
DR   Gene3D; 1.10.532.10; STAT transcription factor, N-terminal domain; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR001217; STAT.
DR   InterPro; IPR038295; STAT1_C_sf.
DR   InterPro; IPR035859; STAT1_SH2.
DR   InterPro; IPR022752; STAT1_TAZ2-bd_C.
DR   InterPro; IPR048988; STAT_linker.
DR   InterPro; IPR036535; STAT_N_sf.
DR   InterPro; IPR013800; STAT_TF_alpha.
DR   InterPro; IPR015988; STAT_TF_coiled-coil.
DR   InterPro; IPR013801; STAT_TF_DNA-bd.
DR   InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR   InterPro; IPR013799; STAT_TF_prot_interaction.
DR   PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF12162; STAT1_TAZ2bind; 1.
DR   Pfam; PF01017; STAT_alpha; 1.
DR   Pfam; PF02864; STAT_bind; 1.
DR   Pfam; PF02865; STAT_int; 1.
DR   Pfam; PF21354; STAT_linker; 1.
DR   SMART; SM00964; STAT_int; 1.
DR   SUPFAM; SSF49417; p53-like transcription factors; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   SUPFAM; SSF47655; STAT; 1.
DR   SUPFAM; SSF48092; Transcription factor STAT-4 N-domain; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   3: Inferred from homology;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU046415};
KW   ADP-ribosylation {ECO:0000256|ARBA:ARBA00022765};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU046415};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU046415};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW   Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW   Methylation {ECO:0000256|ARBA:ARBA00022481};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU046415};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW   ECO:0000256|RuleBase:RU046415};
KW   Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU046415};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|RuleBase:RU046415};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          573..670
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
SQ   SEQUENCE   750 AA;  87282 MW;  901C9741E148500C CRC64;
     MSQWYELQQL DSKFLEQVHQ LYDDCFPMEI RQYLAQWLEK QDWEHAANDV SFATIRFHDL
     LSQLDDQYSR FSLENNFLLQ HNIRKSKRNL QDNFQEDPIQ MSMIIYNCLK EERKILENAQ
     RFNQAQSGNV QSTVMLDKQK ELDSKVRNVK DKVMCIEHEI KTLEDLQDEY DFKCKTLQNR
     EHEANGVAKN DQKQEQMLIQ KMYLMLDNKR KEVVLKIIEL LNVTELTQKA LINDELVEWK
     RRQQSACIGG PPNACLDQLQ NWFTVVAESL QQVRQQLKKL EELEQKYTYE HDPITKNKQG
     LWDRTFNLFQ QLIQSSFVVE RQPCMPTHPQ RPLVLKTGVQ FTVKLRLLVK LQELNYNLKV
     KVLFDKDVSE RNTVKGFRKF NILGTHTKVM NMEESTNGSL AAEFRHLQLK EQKNAGTRTN
     EGPLIVTEEL HSLSFETQLC QPGLVIDLET TSLPVVVISN VSQLPSGWAS ILWYNMLVTE
     PRNLSFFLNP PCARWSQLSE VLSWQFSSVT KRGLNVDQLN MLGEKLLGPN AGPDGLIPWT
     RFCKENINDK NFPFWLWIES ILELIKKHLL SLWNDGCIVG FISKERERAL LKDQQPGTFL
     LRFSESCREG AITFTWVERA QGGGEPYFHA VEPYTKKELS AVTFPDIIRN YKVMAAENIP
     ENPLKFLYPN IDKDHAFGKY YSRPKEAPEP MELDGPKGTG YIKTELISVS EVHPSRLQTT
     DNLLPMSPEE FDEVSRIVGS VEFDSMMHAV
//

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