ID A0A3R7K3V6_TRYRA Unreviewed; 376 AA.
AC A0A3R7K3V6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 28-JAN-2026, entry version 20.
DE SubName: Full=Bardet-Biedl syndrome 5 protein {ECO:0000313|EMBL:RNE99990.1};
GN ORFNames=TraAM80_07890 {ECO:0000313|EMBL:RNE99990.1};
OS Trypanosoma rangeli.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Herpetosoma.
OX NCBI_TaxID=5698 {ECO:0000313|EMBL:RNE99990.1, ECO:0000313|Proteomes:UP000283634};
RN [1] {ECO:0000313|EMBL:RNE99990.1, ECO:0000313|Proteomes:UP000283634}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AM80 {ECO:0000313|EMBL:RNE99990.1,
RC ECO:0000313|Proteomes:UP000283634};
RX PubMed=30355302; DOI=10.1186/s12864-018-5112-0;
RA Bradwell K.R., Koparde V.N., Matveyev A.V., Serrano M.G., Alves J.M.,
RA Parikh H., Huang B., Lee V., Espinosa-Alvarez O., Ortiz P.A.,
RA Costa-Martins A.G., Teixeira M.M., Buck G.A.;
RT "Genomic comparison of Trypanosoma conorhini and Trypanosoma rangeli to
RT Trypanosoma cruzi strains of high and low virulence.";
RL BMC Genomics 19:770-770(2018).
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004309}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome, centriolar satellite
CC {ECO:0000256|ARBA:ARBA00004607}.
CC -!- SIMILARITY: Belongs to the BBS5 family.
CC {ECO:0000256|ARBA:ARBA00005822}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RNE99990.1}.
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DR EMBL; MKGL01000352; RNE99990.1; -; Genomic_DNA.
DR RefSeq; XP_029235512.1; XM_029384659.1.
DR AlphaFoldDB; A0A3R7K3V6; -.
DR GeneID; 40331823; -.
DR VEuPathDB; TriTrypDB:TRSC58_05362; -.
DR OMA; PNFGIQY; -.
DR OrthoDB; 10261999at2759; -.
DR Proteomes; UP000283634; Unassembled WGS sequence.
DR GO; GO:0034464; C:BBSome; IEA:InterPro.
DR GO; GO:0034451; C:centriolar satellite; IEA:UniProtKB-SubCell.
DR GO; GO:0036064; C:ciliary basal body; IEA:TreeGrafter.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:TreeGrafter.
DR GO; GO:0060271; P:cilium assembly; IEA:TreeGrafter.
DR InterPro; IPR006606; BBL5.
DR InterPro; IPR030804; BBS5/fem-3.
DR InterPro; IPR014003; BBS5_PH.
DR PANTHER; PTHR21351:SF0; BARDET-BIEDL SYNDROME 5 PROTEIN; 1.
DR PANTHER; PTHR21351; BARDET-BIEDL SYNDROME PROTEIN 5; 1.
DR Pfam; PF07289; BBL5; 1.
DR PIRSF; PIRSF010072; DUF1448; 1.
DR SMART; SM00683; DM16; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000283634}.
FT DOMAIN 41..95
FT /note="BBSome complex member BBS5 PH"
FT /evidence="ECO:0000259|SMART:SM00683"
FT DOMAIN 170..224
FT /note="BBSome complex member BBS5 PH"
FT /evidence="ECO:0000259|SMART:SM00683"
SQ SEQUENCE 376 AA; 42185 MW; 37E1FDF6515AADCD CRC64;
MSSSNTEIQA VVAKAFTFWF DREFRFNIAD DELAVQTARG ETLLTVLRPV EDTRGNCGEE
GVLTVTNLRC IWQSKLNPRK SLSIGYYGIQ NVEVKEVITR PRATTEALYI NTRFRVNRYE
FVFTFMGQTP HQFFIVPVVW RAYDSSRSYR ELRMRSSLVR GGDIVVLPGE RLFTRLEGVT
NVSEDRGVVG VFVTTNVRFV WFAQHSQNIN ISIPLLQLTL LRLRPTKYGA VLLLETSTHA
GGCLLGFRVD PVERLRELFQ ECVSLWKAWN MRPVLGIAVT LQEPNPGAAE DGGLNNVGSG
TGALDGGLAK PVLPQPRKLD GENVVHQVQN DAFAAYYADM GQKGADRRPE YDPSIGLAVE
RLRTGVTLRD LWTVTV
//
