ID A0A3S0I4E4_9BACI Unreviewed; 417 AA.
AC A0A3S0I4E4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 18-JUN-2025, entry version 19.
DE RecName: Full=L-rhamnose isomerase {ECO:0000256|HAMAP-Rule:MF_00541, ECO:0000256|NCBIfam:TIGR01748};
DE EC=5.3.1.14 {ECO:0000256|HAMAP-Rule:MF_00541, ECO:0000256|NCBIfam:TIGR01748};
GN Name=rhaA {ECO:0000256|HAMAP-Rule:MF_00541,
GN ECO:0000313|EMBL:RTQ96255.1};
GN ORFNames=EKG35_00975 {ECO:0000313|EMBL:RTQ96255.1};
OS Lysinibacillus telephonicus.
OC Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Bacillaceae;
OC Lysinibacillus.
OX NCBI_TaxID=1714840 {ECO:0000313|EMBL:RTQ96255.1, ECO:0000313|Proteomes:UP000276349};
RN [1] {ECO:0000313|EMBL:RTQ96255.1, ECO:0000313|Proteomes:UP000276349}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S5H2222 {ECO:0000313|EMBL:RTQ96255.1,
RC ECO:0000313|Proteomes:UP000276349};
RA Yu L.;
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the interconversion of L-rhamnose and L-rhamnulose.
CC {ECO:0000256|HAMAP-Rule:MF_00541}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-rhamnopyranose = L-rhamnulose; Xref=Rhea:RHEA:23160,
CC ChEBI:CHEBI:17897, ChEBI:CHEBI:62346; EC=5.3.1.14;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00541};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00541};
CC Note=Binds 1 Mn(2+) ion per subunit. {ECO:0000256|HAMAP-Rule:MF_00541};
CC -!- PATHWAY: Carbohydrate degradation; L-rhamnose degradation; glycerone
CC phosphate from L-rhamnose: step 1/3. {ECO:0000256|HAMAP-Rule:MF_00541}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00541}.
CC -!- SIMILARITY: Belongs to the rhamnose isomerase family.
CC {ECO:0000256|HAMAP-Rule:MF_00541}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RTQ96255.1}.
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DR EMBL; RXNR01000002; RTQ96255.1; -; Genomic_DNA.
DR RefSeq; WP_126292439.1; NZ_CP155468.1.
DR AlphaFoldDB; A0A3S0I4E4; -.
DR OrthoDB; 9766697at2; -.
DR UniPathway; UPA00541; UER00601.
DR Proteomes; UP000276349; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008740; F:L-rhamnose isomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019324; P:L-lyxose metabolic process; IEA:TreeGrafter.
DR GO; GO:0019301; P:rhamnose catabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.20.20.150; Divalent-metal-dependent TIM barrel enzymes; 1.
DR HAMAP; MF_00541; RhaA; 1.
DR InterPro; IPR050337; L-rhamnose_isomerase.
DR InterPro; IPR009308; Rhamnose_isomerase.
DR InterPro; IPR036237; Xyl_isomerase-like_sf.
DR NCBIfam; NF002203; PRK01076.1; 1.
DR NCBIfam; TIGR01748; rhaA; 1.
DR PANTHER; PTHR30268; L-RHAMNOSE ISOMERASE; 1.
DR PANTHER; PTHR30268:SF0; L-RHAMNOSE ISOMERASE; 1.
DR Pfam; PF06134; RhaA; 1.
DR SUPFAM; SSF51658; Xylose isomerase-like; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00541};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|HAMAP-Rule:MF_00541};
KW Manganese {ECO:0000256|ARBA:ARBA00023211, ECO:0000256|HAMAP-Rule:MF_00541};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW Rule:MF_00541}; Reference proteome {ECO:0000313|Proteomes:UP000276349};
KW Rhamnose metabolism {ECO:0000256|ARBA:ARBA00023308, ECO:0000256|HAMAP-
KW Rule:MF_00541}.
FT BINDING 261
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00541"
FT BINDING 293
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00541"
FT BINDING 295
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00541"
SQ SEQUENCE 417 AA; 47975 MW; C6DF87608C0B5440 CRC64;
MTTTISYEQA KAYYEQWGVN VDLALKQLNQ IPISIHCWQG DDISGFETIK SELSGGIDVT
GNYPGKARNG DELRSDLEKA LSLIPGKHRV NLHAIYAETN GQFVDRDEIL PEHFAKWVDW
AKQNGLGLDF NPTLFSHEKA NDGLTLSHPD EHIRQFWIDH CIASRKIGEY FGKELGTPCL
TNIWIPDGYK DIPSDRLTPR VRLKESLDTI FEYKTDEKYN IDAVESKLFG LGSESYVVGS
HEFYLSYAQQ NNKLCLLDTG HFHPTETISN KISTMLLFNE KVALHVSRPV RWDSDHVVIL
DDELKEIALE IVRNNAIERV LIGLDFFDAS INRIAAWIIG TRNMIKALLY ALLIPHNYLK
ELQEQGNFTE RLALIEEFKT YPFGAIWDHY CEISNVPIRE KWLQEVQIYE KDILSKR
//
