ID A0A419T4K6_9FIRM Unreviewed; 633 AA.
AC A0A419T4K6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 28-JAN-2026, entry version 28.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=BET03_11235 {ECO:0000313|EMBL:RKD32477.1};
OS Thermohalobacter berrensis.
OC Bacteria; Bacillati; Bacillota; Tissierellia; Tissierellales;
OC Thermohalobacteraceae; Thermohalobacter.
OX NCBI_TaxID=99594 {ECO:0000313|EMBL:RKD32477.1, ECO:0000313|Proteomes:UP000284177};
RN [1] {ECO:0000313|EMBL:RKD32477.1, ECO:0000313|Proteomes:UP000284177}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CTT3 {ECO:0000313|EMBL:RKD32477.1,
RC ECO:0000313|Proteomes:UP000284177};
RA Poppleton D.I., Gribaldo S.;
RT "Novel Firmicutes and Novel Genomes.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RKD32477.1}.
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DR EMBL; MCIB01000011; RKD32477.1; -; Genomic_DNA.
DR RefSeq; WP_120168572.1; NZ_MCIB01000011.1.
DR AlphaFoldDB; A0A419T4K6; -.
DR OrthoDB; 9804504at2; -.
DR Proteomes; UP000284177; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR FunFam; 3.40.50.300:FF:001064; Selenocysteine-specific translation elongation factor; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 3.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:RKD32477.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000284177}.
FT DOMAIN 1..172
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 633 AA; 72470 MW; 47A9EBB94E877D8E CRC64;
MKNIIIGTAG HIDHGKTELI RALTGTDTDR LKEEKERGIS IELGFTYFDL PSGRRAGIID
VPGHERFIKN MLAGVAGIDI VILVIAADEG VMPQTKEHLD ILNMLNIKKG IVALTKIDLV
DDEWLNLVKE DIKEHLKGTF LESSPVIEVS SIKGIGINKL INTIDKLTEE VEERDIKATP
RLPIDRVFTI SGFGTIVTGT LIEGRIKVGD EVQIFPGNKI TRIRSIQVHG NDTDVAYGGQ
RVAINLAGVK KSDINRGDVV APVNSMEPTM MLDVKLRLLE DSQRIIENRT RLRLHIGTNE
IFCRAVLLDK DMLLPGESCY AQLRLEEKIV AKRKDRFIVR FYSPMVTIGG GEILEPNPNK
KKRFDEEAIE ELKIKEQGDN KDILEKIVKD NSKDFLNVQE LSKLAVMPEN QILEIINKLE
DRVVKFNLLK DTHIIHKEFY EQLKDEIVNE LKKFHKNYPL KSGMLKEEVR SKYLGDVKPK
LGDNFINNLI EENIIKQIKE NIALKEFEPT FTKKQKDIKE KIEEEYKKAR YKPPKKDEVI
SKLDYDKKEI EHVYEALLDL NILIKAKEGI IFHKEVYEKG IEIVKNFISK NGSITLAEFR
DLIGTSRKYA MALLESYDQQ KITRRIEDKR ILY
//
