ID A0A421CZ44_9EURO Unreviewed; 938 AA.
AC A0A421CZ44;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 18-JUN-2025, entry version 21.
DE RecName: Full=PRP1 splicing factor N-terminal domain-containing protein {ECO:0000259|Pfam:PF06424};
GN ORFNames=CFD26_102858 {ECO:0000313|EMBL:RLL95135.1};
OS Aspergillus turcosus.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=1245748 {ECO:0000313|EMBL:RLL95135.1, ECO:0000313|Proteomes:UP000215289};
RN [1] {ECO:0000313|EMBL:RLL95135.1, ECO:0000313|Proteomes:UP000215289}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HMR AF 1038 {ECO:0000313|EMBL:RLL95135.1};
RA Parent-Michaud M., Dufresne P.J., Fournier E., Martineau C., Moreira S.,
RA Perkins V., De Repentigny L., Dufresne S.F.;
RT "Draft genome sequences of two Aspergillus turcosus clinical strains
RT isolated from bronchoalveolar lavage fluid: one azole-susceptible and the
RT other azole-resistant.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Associated with the spliceosome.
CC {ECO:0000256|ARBA:ARBA00011524}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RLL95135.1}.
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DR EMBL; NIDN02000167; RLL95135.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A421CZ44; -.
DR STRING; 1245748.A0A421CZ44; -.
DR OrthoDB; 440128at2759; -.
DR Proteomes; UP000215289; Unassembled WGS sequence.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IEA:TreeGrafter.
DR GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IEA:TreeGrafter.
DR GO; GO:0000244; P:spliceosomal tri-snRNP complex assembly; IEA:TreeGrafter.
DR FunFam; 1.25.40.10:FF:000649; mRNA splicing factor (Prp1/Zer1), putative; 1.
DR FunFam; 1.25.40.10:FF:001164; mRNA splicing factor (Prp1/Zer1), putative (AFU_orthologue AFUA_2G06070); 1.
DR FunFam; 1.25.40.10:FF:000256; Probable pre-mRNA splicing factor prp1; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR010491; PRP1_N.
DR InterPro; IPR045075; Syf1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_rpt.
DR PANTHER; PTHR11246; PRE-MRNA SPLICING FACTOR; 1.
DR PANTHER; PTHR11246:SF1; PRE-MRNA-PROCESSING FACTOR 6; 1.
DR Pfam; PF06424; PRP1_N; 1.
DR Pfam; PF13428; TPR_14; 1.
DR Pfam; PF13432; TPR_16; 1.
DR Pfam; PF14559; TPR_19; 1.
DR SMART; SM00386; HAT; 12.
DR SMART; SM00028; TPR; 5.
DR SUPFAM; SSF48452; TPR-like; 3.
DR PROSITE; PS50005; TPR; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000215289};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT DOMAIN 13..176
FT /note="PRP1 splicing factor N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06424"
FT REPEAT 606..639
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 1..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 116..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 481..513
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 77..91
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 938 AA; 105540 MW; 981E95C5FA755822 CRC64;
MASGRKDFLN QPAPENYVAG LGRGATGFTT RSDLGPAREG PTPEQIQAAL AKRAQLLGAA
PPTAYGAGRE KGGREEKEEE EEDERFQDPD NEVGLFAYGQ FDQEDDEADR IYKEVDEKMD
KRRKARREAR ERQEREEYER KNPKIQQQFA DLKRSLASVS EEQWANLPEV GDLTGKNRRA
RQNLRQRFYA VPDSVIASAR DSTQFETTIA DDGTQTDVRG AEADGTMTNF ADISAARDKV
LKVRLDQAAR GSTADSSSGS ATNIDPKGYL TSLTQSELKA GEIEIGDIKR VRVLLESVTK
TNPKHAPGWI ALALLEELAG RIVAARNIIA KGCELCPKSE DAWLQNIRLN EGHNAKVIAA
NAIRNNDRST RLWIEAMRLE TDTRAKKNVL RQAILHVPQS VAIWKEAVNL EEDPADARLL
LAKAVEMIPL SVELWLALAR LETPENAQKV LNAARKAVPT SHEVWIAAAR LQEQMGTFEK
VNVMKRAVQA LARENAMLKR EEWIAEAEKC EEEGAILTCG AIIRETLGWG LDEDDDRKDI
WMDDAKASIN RGKYETARAI YAYALRVFVN RRSIWLAAAD LERNHGSKEA LWQVLEKAVE
ACPQSEELWL QLAKEKWQAG EIDDARRVLG RAFNQNPNNE DIWLAAVKLE ADADQTDQAR
DLLATARREA GTDRVWIKSA AFERQLGNID EALDLVNQGL QLYPKADKLW MMKGQIYEYQ
NKYPQAREAY STGTRACPKS VPLWLLASRL EEKYGAVVKA RSILDRARLA VPKSAELWTE
SVRVERRANN IGQAKVLMAK ALQEVPTSGL LWSESIWHLE PGAQRKARTM EAIKKVDNDP
MVFITAARIF WEDRKLEKAM TWFEKAIVAD SDHGDGWAWY YKFLLQHGTE EKRADVVAKC
VATEPKHGEV WQSVAKDPAN ARKSTEEILK MVADRLTK
//
