ID A0A422Q071_9TRYP Unreviewed; 3602 AA.
AC A0A422Q071;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 02-APR-2025, entry version 15.
DE SubName: Full=Putative neurobeachin/beige protein {ECO:0000313|EMBL:RNF23391.1};
GN ORFNames=Tco025E_02907 {ECO:0000313|EMBL:RNF23391.1};
OS Trypanosoma conorhini.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=83891 {ECO:0000313|EMBL:RNF23391.1, ECO:0000313|Proteomes:UP000284403};
RN [1] {ECO:0000313|EMBL:RNF23391.1, ECO:0000313|Proteomes:UP000284403}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=025E {ECO:0000313|EMBL:RNF23391.1,
RC ECO:0000313|Proteomes:UP000284403};
RX PubMed=30355302; DOI=10.1186/s12864-018-5112-0;
RA Bradwell K.R., Koparde V.N., Matveyev A.V., Serrano M.G., Alves J.M.,
RA Parikh H., Huang B., Lee V., Espinosa-Alvarez O., Ortiz P.A.,
RA Costa-Martins A.G., Teixeira M.M., Buck G.A.;
RT "Genomic comparison of Trypanosoma conorhini and Trypanosoma rangeli to
RT Trypanosoma cruzi strains of high and low virulence.";
RL BMC Genomics 19:770-770(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RNF23391.1}.
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DR EMBL; MKKU01000119; RNF23391.1; -; Genomic_DNA.
DR RefSeq; XP_029230134.1; XM_029369830.1.
DR GeneID; 40316518; -.
DR OrthoDB; 26681at2759; -.
DR Proteomes; UP000284403; Unassembled WGS sequence.
DR CDD; cd06071; Beach; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR050865; BEACH_Domain.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR13743:SF112; BEACH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR SMART; SM01026; Beach; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000284403}.
FT DOMAIN 2877..3177
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REGION 641..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1970..1993
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2019..2146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3175..3204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 667..678
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1970..1988
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2032..2073
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2092..2101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3187..3204
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3602 AA; 395980 MW; BD0D7FEA151DE3B0 CRC64;
MPALSERDLL SVEKFSNAMK AALELRSRQA KLRHTDAQAT PSPSTAVPGD AAELLAEGRL
WAEAAVVFWR LASRQQMHLL SYATTDAARD LCGLCDGLLD HIRTTFESLG PSATPLQVVE
SAASFATEHI FFFLSAFCLP KSCINMAGGE ERLGREVHGH VCKVLAEQDH LRWMTRLFRA
FCDESWRMYS ERGSIAGAAV SATHDVLRCL SHCCAVSEAC AQVLIYTEPR PLVAQLLYGL
RLRISNNALI RPLVSDGSAW EGGGRPPTPL PPSGLRVPTR KAELAEYLAA GRKNAYDALS
REALNAAVAA VKKAAAHDTP DVVVALCHII EVSSRSIVPP QKEEEKLPMG LQIAMYENVM
MAWDALCQLI ITKDDDPLRH DIVVRQEAVL QQLLNYDLAG CVRRLLQHCP DIVDCDRTLF
ETIAMFCTPP STSSKRRRPS TQVTRIEHSA HRITGSIDSL TGSMCSRSES GCSLTSSIHL
PRPTPPEAAA TRLSSRARPL WPGFWPAASP TAAGGSQFAY AHVTSCPAAL ERDPSGSPQL
RVPGDAVFDY TSSPVFLPAY VDGEEWWYNN KLYVDLVHSL TQVLNEAFTN VTTPLSLRLF
LCTLLAQISM RSSSAFAASE GRLVLRSFLR TLRACGQRPR MASPAAYSSP CGGEEQSVSR
RMSPATHGKE GGKGPHEPMD EDTMCALLAH RIVAAIWHVY QVLHLLPLSG EMVDIIELPL
LPLRWGGEAE PAEVEEGATR TACGDRKAFT GLFAPLVRVW YTGLLSNDDE DFNKRSQEVL
MEVFLGLLKV GGAALTASEV PGVSAAAPAS STPSATPTWV ASRSTESSFA SLEVEAPAVE
FGDTIKSLRN IFMILLQRDP GFLASEILQV LFSLLWANDA QLTELGRRCI ASSLDFEEVY
PTYAKVIRDA EPSLLTKLLP LFAAELLSPE VSTDAKHERR VWLFQHDCVN AVIAVLERVL
LAPHTVVCFP RLIRQLFCFL SVSESAQGRE PRLADTQLTH VFTKNLPCVE GAEYLILIAQ
SVLEAATSAF DKYRDHAQRV NTHGLFALSV PNCSVEKPVF IDLLPPLLQY AHAHAKDLES
DLLSALHLIL KMTTKVHSNA LLAWVLQGKQ TALLPYLDLD AAAAYSVLPY VGDRGEIEPF
WTPILQEAPE RAELRFSSAG GIAVTLGRWP EKGFSVSAYF RFEEIYSNIQ LFEFLDGEAS
LPPLASIRIA GGDSVIILHD GRRVPVNESH ALPDLAPQRW AHFLVVMSVA HTVSVYLNAN
KVGTCTLPYF RPHSEVTMHV GFVNAPVHDA LFSIGGVVLW EEELTAPQVE AYAATTEYQP
NVCKILEREI PRELAETHEA LPIEDRIAMF VPYETRDSLL VNILQRTSKS CPIMAKLTGN
YAVAPKNWID YRDLFLSQGG LQHLLDWVAA SATSEELARY MALAADCMRG VTNGGTMDFR
TYALLGFHLR RLAHLVTPDV CDGLLRLATA NVSVNDELHP FIINRLVFDH ILRDIELLAG
MPPDSALYLT GSLERLFTVA SCRFARRNAN YILPFRFVDG VLNGLVYANV SLPFAVRARL
ISCVKHIMIA TDFEPNIVHI VASTAAVLTP GEMEVASQLQ PALRVKLPKP RFAETRVSPH
GACDLTPLIL RSLVECCSSS TFLAAFGLVV DLNWYAVCVS RFADASCVVY STRLFFEALR
SNMDLRQQVM HHPAAVVEAL SPHRLNVDLL LLLLSLSVGA ERRIDVLSSK HPLLQQLVGI
LDSITPLLDP VVAPIFSKVL TLHLTAALST PACFRPCGAS SVMQRRLCCS YRLHRPFALA
RVCSILMLQI YARRLLFQTT KAGVTAAAAA GRVASRQSSP NEDGSSSDVA ADATTTFPCF
GRHRRALLAL RVCVYFWKAI QRRRYSKLLQ RVSGAAPLMV ADADSEKTLF ILRTLQTLPL
KQGLFLPCTL SPYQIEALAF FGTFLQREAV LSRCAEKLRS RNFGAASFTA ATSPGSTINT
EATGSSEASA KLSKPSDEVW SALLTHVTGT DDAVKHGVGA ADAAAEEEGE GEERIRRQEP
HRQGRQQEKG EEVAMRKEAV AKLRQEGEAE HHAQRPTTAT PPTEPRKRET RSLLSNPSPQ
DNPCAPRSPS LFAASVSTEA ASLPESMEER AASASESKLE LMPGVGNSSG ADGDLASGLA
GLVLSVEGST LHSELEEAVS ADVAIGAFAP LTNLPSSTTK SLQESAVGVL SHTILASLLN
LPVTGGWVGG ETYGSCGALL FQLMLVTGAM ANAEELTATL THFVIDQLLV CVDLVEGLVE
PKASFITSLK GSGLEHRARR VNSSQDSVSD VFVFNVCRLN ELLVHFVSFD VMPLSSLSPY
FVWLLGWAST AWPHRSQQLL RSQVVKSCIA VLNRPSLNGV TPEQMEIVYM LLGRVLCPQW
IMKDMLECLL RVLLRLYTSL PPSSMNEADA RRRKELAILT LRLMMHTYGG SKELIKALSA
SALRQRISLY KEFAAVLLLL DEAAAVAAFE AYYQENMTTV DGVMSGRPKT KADIAYKSML
KDRSEYVERI NKFKEAYSKT IEVGDSYRRA ELVQVYTARF SSCVGHISPL KPCQLHWLVT
EQCSLQQASP CVRALNYLDS RCNYTTVLSD RFTEDTASLV PSADNCEQQL NHVSALVQPF
AMRCRPYLLH SSAPFVDSRC RVSPAAVSLL RYLLEPNEVL RFISNGFRIK GIHATPCLIL
LTDTTLKLIG FSRITVAGDI VLCQCANEEA GEPAFPTTGS VAKSSKAKGG YQLTASSFAL
SMTSKLQRFL TDGAGKERRR REREELHDGT KIAHSVRQAS GNSYRDLFWV YLLQNFRSVR
MAYYMHQDTA ILFKLMYADG PMLSLVDAQQ SMNTSARDKF LEVLKEVLGT QRCKFHEHAQ
RAARIRSMLI RWAAGSVSTY DYLTFLNRVA GRTRLDFNQY PIYPWVLADY KSSELELDAA
KTYRDLSLPM GAQTEERRQK VMQVYQQMVE MQETAPEGES VQPFHHGTHY STSGGVLHFL
IRVEPFTTFA RIFQGGEFDV ATRLFDSVEA SFQSCVNGPT DCKELVPEFF FDGMFLVNTN
HCAFGEKSDG TVVNDVKLPP WAKGSPQVFV SVMRYVLESE FVVQNIHRWI DLIFGVRRRG
RLAVESYNVF QRMTYGEEVL QALKKCDNPH DTDVIIAEVD NFGQTPMQLF QERHPAQREL
EPCHPPSSTS SGGTGGANST ASGAVRRTGH TYTTAFQEQL PKVLAMIMHA LDSPHAWYTL
EDPVPGSFQA LPECLADDIL IHESAVIDFA TTRSGLKMCC YKYVSPVDDM DHVLCWSHGE
HVLRRFDNTR GCFLSSLRCN LVCVIPASVS ALCVGCRGTL ILLGSSSGMV HCLSPTRSDG
MLLLTATLCH HTHPIAGFAL NAKFGRIISF TVSGTDSPVV WCVQHRHTAK LHLLDAALLL
PAVDVVDLVV VAAAVDPRSA NSIIITRRHL LIFDRHGEPY GVGALPGLDE AAPHLEDEKG
QVGFAVENGT TFIASMTAVT TYDTPEWAAG MQLLLTGHDD GSLSLWRAVR LPPDKVKHGR
IVTVEYHGLI VAGSQTSRLG AVTALRQEQP GVPVFLVGYD SGAVKVLSFE NRTADTTKTT
KT
//
