ID   A0A444RK57_VERDA        Unreviewed;       771 AA.
AC   A0A444RK57;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   08-OCT-2025, entry version 24.
DE   RecName: Full=Terpene cyclase/mutase family member {ECO:0000256|RuleBase:RU362003};
DE            EC=5.4.99.- {ECO:0000256|RuleBase:RU362003};
GN   ORFNames=VDGE_09360 {ECO:0000313|EMBL:RXG41507.1};
OS   Verticillium dahliae (Verticillium wilt).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Verticillium.
OX   NCBI_TaxID=27337 {ECO:0000313|EMBL:RXG41507.1, ECO:0000313|Proteomes:UP000288725};
RN   [1] {ECO:0000313|EMBL:RXG41507.1, ECO:0000313|Proteomes:UP000288725}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Getta Getta {ECO:0000313|EMBL:RXG41507.1,
RC   ECO:0000313|Proteomes:UP000288725};
RA   Gardiner D.M.;
RT   "Genome of Verticillium dahliae isolate Getta Getta.";
RL   Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC       {ECO:0000256|ARBA:ARBA00009755, ECO:0000256|RuleBase:RU362003}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RXG41507.1}.
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DR   EMBL; RSDZ01000211; RXG41507.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A444RK57; -.
DR   Proteomes; UP000288725; Chromosome 4.
DR   GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR   GO; GO:0000250; F:lanosterol synthase activity; IEA:TreeGrafter.
DR   GO; GO:0006696; P:ergosterol biosynthetic process; IEA:TreeGrafter.
DR   GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR   CDD; cd02892; SQCY_1; 1.
DR   FunFam; 1.50.10.20:FF:000003; Terpene cyclase/mutase family member; 1.
DR   Gene3D; 1.50.10.20; -; 2.
DR   Gene3D; 6.20.120.20; -; 1.
DR   InterPro; IPR032696; SQ_cyclase_C.
DR   InterPro; IPR032697; SQ_cyclase_N.
DR   InterPro; IPR018333; Squalene_cyclase.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   NCBIfam; TIGR01787; squalene_cyclas; 1.
DR   PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR   PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR   Pfam; PF13243; SQHop_cyclase_C; 1.
DR   Pfam; PF13249; SQHop_cyclase_N; 1.
DR   SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU362003};
KW   Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Steroid biosynthesis {ECO:0000256|ARBA:ARBA00022955}.
FT   DOMAIN          158..377
FT                   /note="Squalene cyclase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13249"
FT   DOMAIN          427..756
FT                   /note="Squalene cyclase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13243"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..24
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   771 AA;  87828 MW;  F69A3F15C85C77CE CRC64;
     MNGSLKNGST NGSHRNGSSK NGSATHHEDK PLLSRKRVAE AIAEQPWPKK PRILEKTDVS
     RWRLNDEDGR HRWVYVEDNK ALKDWPQSYA EKYYLGLPLG LPDLPPPESP LDAATNGLTF
     FEKLQLDFGE WGCEYGGPMF LLPGIVITWY VTKTPISTFH ATEIKNYLFA RADPELGGWG
     LHTEGESTAF GCALSYTALR LLGVDAEDPI MVKARARLHQ LGGATSSPHW AKWWLAVLGV
     ASWDLVNPVP PELWLVPDWV PIAPWRWWIH IRQVYLPMSY IYSRRWSCEE TDVTRQLKNE
     LFVQQHASIN WKAHRNDIAT TDNYHPKTWV LNTVNWLLVN VWEPYLKTSS IKEKAEAWVS
     ELVDMEDANT DYAGVAPVSN SMNEIVCYVR DGPGSYSVRR HTERLHDALW MNAEGMLCNG
     TNGVQSWDTA FTIQAIMAAG LEKDERWRPM LNKALGFLDR QQIRENCKDQ EKCYRQHRKG
     GWPFSNRDQG YIVSDCVSEC IKSVIMLQKS EGYPQLLDDQ RIFDAIDAIL LFQNDTGGVG
     TYENRRGGKY MEYLNAAEVF GNIMVEYDYP ECTTACLTAL SLFREHWPDY RAEEIKVFCD
     RAVKWITSNQ TAEGGWYGSW GICFTYAAMF ALESLAGVGD VYETSPPSRK GCDFLVGKQR
     FDGGWSESYK ACETMTWVEH PSGSLVVQTA WAALALMEAK YPDVGPIKRA IRFIMSRQQS
     NGEWLAESIE GVFNKSCTIT YPNYKFIFPI KALGLFAKKY PDEVINLEEE D
//