ID A0A452GUK4_9SAUR Unreviewed; 546 AA.
AC A0A452GUK4;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 28-JAN-2026, entry version 30.
DE RecName: Full=ETS domain-containing protein {ECO:0000259|PROSITE:PS50061};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000005444.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000005444.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSGAGP00000005444.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
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DR AlphaFoldDB; A0A452GUK4; -.
DR STRING; 38772.ENSGAGP00000005444; -.
DR Ensembl; ENSGAGT00000006337.1; ENSGAGP00000005444.1; ENSGAGG00000004415.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:TreeGrafter.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:UniProtKB-ARBA.
DR FunFam; 1.10.10.10:FF:000066; ETS-related transcription factor Elf-2 isoform X1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR022084; TF_Elf_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF10; ETS-RELATED TRANSCRIPTION FACTOR ELF-2; 1.
DR Pfam; PF12310; Elf-1_N; 1.
DR Pfam; PF00178; Ets; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004019};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 160..242
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
FT REGION 101..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..133
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..143
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 546 AA; 59197 MW; 0FBDC0A4A401FF54 CRC64;
MPSKLLEEII DISSDSSLRT RFNDMLLETF QLEASVHGSN VHCTDKTIEA AEALLHMESP
TCLRDARSPV EVFVPPCVST PEFIHAAMRP DVITETVVEV STEESEPMDM SPVPTSPDIR
EPMKKKKAGR KPKTQQSAIS NGSPDLGIKK KPREGKGNTT YLWEFLLDLL QDKNTCPRYI
KWTQREKGIF KLVDSKAVSK LWGKHKNKPD MNYETMGRAL RYYYQRGILA KVEGQRLVYQ
FKEMPKNIVV IDDDKSESCS EDLAMPTDEK SLERVSLSAE SLLKAAASAR GGKNSSPLNC
TRAEKAVTRV VNIASPGHDT SSRPPTTTTT VPATAAPRTV RVAMQVPVVM TSLGQKISTV
AVQSVNAGSP LITSTSPTTA TTPKVVIQTI PTVMPASAEN GDKITMQPAK IITIPATQLT
QCQLQTKTGL TGSGSINIVG TPLAVRALTP VSIAHGTPVM RLSMPAQQAS GQTPPRVISA
VIKGPEVKPD TVALKQEREM KTLQLVQEEK PADGSKTVTH VVVVSTPSAI ALPLTMKTEG
IVTCEK
//
