ID A0A452SBK7_URSAM Unreviewed; 850 AA.
AC A0A452SBK7;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 28-JAN-2026, entry version 29.
DE SubName: Full=Zinc finger protein 598, E3 ubiquitin ligase {ECO:0000313|Ensembl:ENSUAMP00000029711.1};
GN Name=ZNF598 {ECO:0000313|Ensembl:ENSUAMP00000029711.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000029711.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000029711.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSUAMP00000029711.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
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DR AlphaFoldDB; A0A452SBK7; -.
DR STRING; 9643.ENSUAMP00000029711; -.
DR Ensembl; ENSUAMT00000033145.1; ENSUAMP00000029711.1; ENSUAMG00000022859.1.
DR GeneTree; ENSGT00390000014178; -.
DR OMA; CEKKYDI; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0043022; F:ribosome binding; IEA:TreeGrafter.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:TreeGrafter.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:InterPro.
DR InterPro; IPR057634; PAH_ZNF598/HEL2.
DR InterPro; IPR056437; Znf-C2H2_ZNF598/HEL2.
DR InterPro; IPR044288; ZNF598/HEL2.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR059042; Znf_C2H2_ZNF598.
DR PANTHER; PTHR22938:SF0; E3 UBIQUITIN-PROTEIN LIGASE ZNF598; 1.
DR PANTHER; PTHR22938; ZINC FINGER PROTEIN 598; 1.
DR Pfam; PF23202; PAH_ZNF598; 1.
DR Pfam; PF25447; RING_ZNF598; 1.
DR Pfam; PF23230; zf-C2H2_13; 1.
DR Pfam; PF23208; zf_C2H2_ZNF598; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 127..148
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS00028"
FT REGION 218..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 434..511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 523..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..301
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..330
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..371
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..401
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..474
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..486
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 596..612
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 850 AA; 93068 MW; 3848DDB880BFF9B1 CRC64;
MVLLTSPLTW FQVVFGKKLP AFATIPLQQL QHEKKYDIYF ADGKVFALYR QLLQHECPQC
PELPPFGLFG DLEQHMRKQH ELFCCKLCLK HLKIFTYERK WYSRKDLARH RMQGDPDDTS
HRGHPLCKFC DERYLDNDEL LKHLRRDHYF CHFCDSDGAQ DYYSDYAYLR EHFREKHFLC
EEGRCSTEQF THAFRTEIDL KAHRTACHSR SRAEARQNRQ IDLQFSYAPR HSRRNEGVVG
GEDYEEVDRY NRQGRTGRAS GRGAQQSRRG SWRYKREEED REVAAAIRAS VAVQQQQQQQ
QETRRSEDRE EDGRAKKEEA GLRGLEEPRG PRRPPRTQGE GAGLKEASPN GPVSQEGLPA
PGPATGATLP STLPPPTSKL KDEDFPSLCA STSSSSSSCS AATALGPVGL ALAYPVPARG
RSTFQEDDFP ALVSSACKPS TAPTSLISAW NSSSSKKVAH PSTGAQAAGG SSQPPRKAGK
GGKGSKKGGL PPSEEEEEDG RAGLTAQELR SVPTTVAVSS LLALASTQTV TKVGKKKKVG
LEKPGAASPP PLPPDKDGPP GAEEAPTTTA GRAEGPIALI VNGHTEGPAP ARSTPKEPPG
LPRPLGPLPC PTPQEDFPAL GVPCPPRMPP PPGFNAVVLL KGTPPPPPPG LVPPVSKPPP
GFSGLLPSPH PACVPSTATT TKAPRLTPTP QAYLVPENFR ERNLQLIQSI KDFLQSDEAR
FGKFKSHSGE FRQGVISAAQ YYKSCRDLLG ENFQKIFNEL LVLLPDTAKQ QELLSAHTHF
RGRERPPGTK AKKNKKSAWQ ASTRPAGLDC CVCPTCQQVL AHGDVSSHQA LHAAQDNDFP
SLQAIARILT
//
