ID   A0A485MT99_LYNPA        Unreviewed;      1075 AA.
AC   A0A485MT99;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   02-APR-2025, entry version 20.
DE   SubName: Full=Mitotic checkpoint {ECO:0000313|EMBL:VFV23284.1};
GN   ORFNames=LYPA_23C021782 {ECO:0000313|EMBL:VFV23284.1};
OS   Lynx pardinus (Iberian lynx) (Felis pardina).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Lynx.
OX   NCBI_TaxID=191816 {ECO:0000313|EMBL:VFV23284.1, ECO:0000313|Proteomes:UP000386466};
RN   [1] {ECO:0000313|EMBL:VFV23284.1, ECO:0000313|Proteomes:UP000386466}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Alioto T., Alioto T.;
RL   Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC       {ECO:0000256|ARBA:ARBA00004629}.
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DR   EMBL; CAAGRJ010005512; VFV23284.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A485MT99; -.
DR   Proteomes; UP000386466; Unassembled WGS sequence.
DR   GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:TreeGrafter.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0051754; P:meiotic sister chromatid cohesion, centromeric; IEA:TreeGrafter.
DR   GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IEA:InterPro.
DR   FunFam; 1.25.40.430:FF:000002; mitotic checkpoint serine/threonine-protein kinase BUB1 beta; 1.
DR   Gene3D; 1.25.40.430; -; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR015661; Bub1/Mad3.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR013212; Mad3/Bub1_I.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   PANTHER; PTHR14030; MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1; 1.
DR   PANTHER; PTHR14030:SF25; MITOTIC CHECKPOINT SERINE_THREONINE-PROTEIN KINASE BUB1 BETA; 1.
DR   Pfam; PF08311; Mad3_BUB1_I; 1.
DR   SMART; SM00777; Mad3_BUB1_I; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS51489; BUB1_N; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   4: Predicted;
KW   Centromere {ECO:0000256|ARBA:ARBA00023328};
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW   Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW   Reference proteome {ECO:0000313|Proteomes:UP000386466}.
FT   DOMAIN          160..324
FT                   /note="BUB1 N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51489"
FT   DOMAIN          826..1075
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          346..366
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          553..574
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        350..366
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        561..574
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1075 AA;  122133 MW;  7B1B97CCD290D0F9 CRC64;
     MATAWTKPGL NYKPQNSLGE RREYERTEGR IHVVRAGPLN LKLGGFEVAA LRRSQVHPFV
     LLVSSLSLRA GCRRKPRGSA ALRKGLRQDE GLNPECRMAA MKKEGGALSE AMSLEGDEWE
     LSKENVQPLR QGRIMSTLQG ALAQQESACN TTLQQQKRAF ESEIRFYTGN DPLDVWDRYI
     NWTEQNYPQG GKESNMSTLL ERAVEALQGE KRYYNDPRFL SLWLKLGYLC IEPLDMYSYL
     HNQGIGVSLA QFYISWAEEY EARENFKKAD KIFQEGIQQK AEPLERLQSQ HRQFQARVSR
     QTVLALEKEE EEEVFGSSVP QRSTLAELKS KGKKTARAPI SRVGGALKAP NQNRGLQNPV
     PQQMQSNSRV TIFDENADEA SRAELSKPAA QPWIARPVSR AKENELQAGP WNTDRPLEYR
     TRGSTASVTA VPSLLPSFTP YVEETAQQPV MTPCKIEPSI NHILSTRKPG KEEGDLLQRV
     QSHQQESQEK KEKMMYCKEK IYAGVGEFSF EEIRAEVFRK KLKERREAEL LTSAEKRAEM
     QKQIEEMEKK LKEIQTTQQE RTGDQQEEKM PTKETAELPI ASESQEIPGM ALSNSVCPVN
     SCARETSLAE NIWPEQPHSK GPSLPFSIFD EFLLSEKKNN SPPADPPQVL AQRRPLAILK
     TSESINSNED VPPDVCDEFT GIEPLSEDAI ITGFRNVTIC PNPEDTCDFA RAARFVSTPF
     HEIMSLKDLP SDPERLLQEE DLDVKISEDQ QTACGIIYNP SLSIKKLSPI IEDSREATHS
     SGYSGSSASV SSSSSIKCLQ IPEKLELTNE TADNPTQSPW CPRYRRQLLK SLSELRASAE
     FFVEDRPMPR LEIGKEIELG HEDYCIKQEY LICEDYKLFW VTPRNSAELT IIKVSSQPVP
     WDFYINLKLK ERLNEEYDHL CSCYQYQDGC IVWHQYINCF TLQDLLQHSE LITHEIIVLV
     IYNLLTIVEK LHRAEIVHGD LSPRSLILRN RIHDPYDCNK NNQALKIVDF SYSVDLRAQL
     DVFVLSGFRT VQILEGQKIL ANCSSPYQQP PTISKLPSNV GAAQRPKRAG RCLRI
//