ID   A0A493T0P2_ANAPP        Unreviewed;       545 AA.
AC   A0A493T0P2;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   28-JAN-2026, entry version 23.
DE   RecName: Full=BBSome complex member BBS5 {ECO:0000256|ARBA:ARBA00047191};
GN   Name=KLHL41 {ECO:0000313|Ensembl:ENSAPLP00000019376.1};
OS   Anas platyrhynchos platyrhynchos (Northern mallard).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anatinae; Anas.
OX   NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000019376.1, ECO:0000313|Proteomes:UP000016666};
RN   [1] {ECO:0000313|Ensembl:ENSAPLP00000019376.1, ECO:0000313|Proteomes:UP000016666}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT   "A new Pekin duck reference genome.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPLP00000019376.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2025) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSAPLP00000019376.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2025) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC       {ECO:0000256|ARBA:ARBA00004309}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome, centriolar satellite
CC       {ECO:0000256|ARBA:ARBA00004607}.
CC   -!- SIMILARITY: Belongs to the BBS5 family.
CC       {ECO:0000256|ARBA:ARBA00005822}.
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DR   AlphaFoldDB; A0A493T0P2; -.
DR   Ensembl; ENSAPLT00000019732.1; ENSAPLP00000019376.1; ENSAPLG00000007022.2.
DR   GeneTree; ENSGT00940000158859; -.
DR   Proteomes; UP000016666; Chromosome 7.
DR   GO; GO:0034464; C:BBSome; IEA:InterPro.
DR   GO; GO:0034451; C:centriolar satellite; IEA:UniProtKB-SubCell.
DR   GO; GO:0036064; C:ciliary basal body; IEA:TreeGrafter.
DR   GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:TreeGrafter.
DR   GO; GO:0060271; P:cilium assembly; IEA:TreeGrafter.
DR   CDD; cd00900; PH-like; 1.
DR   FunFam; 2.30.29.30:FF:000232; Bardet-Biedl syndrome 5 isoform 1; 1.
DR   FunFam; 2.120.10.80:FF:000025; Kelch-like family member 41; 1.
DR   Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR006606; BBL5.
DR   InterPro; IPR014003; BBS5_PH.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR21351:SF0; BARDET-BIEDL SYNDROME 5 PROTEIN; 1.
DR   PANTHER; PTHR21351; BARDET-BIEDL SYNDROME PROTEIN 5; 1.
DR   Pfam; PF07289; BBL5; 1.
DR   Pfam; PF24681; Kelch_KLHDC2_KLHL20_DRC7; 1.
DR   SMART; SM00683; DM16; 2.
DR   SMART; SM00612; Kelch; 3.
DR   SUPFAM; SSF117281; Kelch motif; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Cilium {ECO:0000256|ARBA:ARBA00023069};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016666}.
FT   DOMAIN          29..83
FT                   /note="BBSome complex member BBS5 PH"
FT                   /evidence="ECO:0000259|SMART:SM00683"
FT   DOMAIN          159..213
FT                   /note="BBSome complex member BBS5 PH"
FT                   /evidence="ECO:0000259|SMART:SM00683"
SQ   SEQUENCE   545 AA;  61565 MW;  723F06BE0A793B23 CRC64;
     MSAVLDVLWE DRDVRFDISP QQMKMRPGEV LIDCLESIED TKGNNGDRGR LLVTNLRIIW
     RSLSLPRVNL SVGYNCIINI TTRTANSKLR GQTEALYILT KCNNTRFEFI FTNVVPGSPR
     LFTSVIAVHR AYETSKMYRD LKLRSALIQN KQLRLLPQEQ IYDKINGVWN LSSDQGNLGT
     FFITNVRIVW HANMNDSFNV SIPYLQIRSI KIRDSKFGLA LVIESSQQSG GYVLGFKIDP
     VEKLQEAVKE INSLHRVYSV NPIFGVDYEM EEKPQPLEDL TVEQVQDDVE IESDEQTDAF
     VAYFADENKL DSIAGEWVAL PPLPSARCLF GLGESDNKIY VIAGKDLRTE ESLDSVLCYD
     PVAIKWGEIK KLPIKVYGHA TISNNGLIYC LGGKTDDKKC TNRVFVYNPK KGDWRDLAPM
     KVARSMFGTA IHKGKIFIAG GVTEEGLTES VEAFDLTTNK WEVLPEFPQE RSSISLVTLS
     GSLYAIGGFA MIQLESKEFA PSEVTDIWKY DDEKKEWIGI LKEIRYATGA SCLATRLNLF
     KLSKL
//