ID A0A494UZ13_9ACTN Unreviewed; 323 AA.
AC A0A494UZ13;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 18-JUN-2025, entry version 26.
DE SubName: Full=2-dehydropantoate 2-reductase {ECO:0000313|EMBL:AYL38825.1};
GN ORFNames=CNQ36_27545 {ECO:0000313|EMBL:AYL38825.1};
OS Streptomyces fungicidicus.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=68203 {ECO:0000313|EMBL:AYL38825.1, ECO:0000313|Proteomes:UP000282170};
RN [1] {ECO:0000313|EMBL:AYL38825.1, ECO:0000313|Proteomes:UP000282170}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TXX3120 {ECO:0000313|EMBL:AYL38825.1,
RC ECO:0000313|Proteomes:UP000282170};
RA Zhang H., Hu S., Xu J., He Z.;
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ketopantoate reductase family.
CC {ECO:0000256|ARBA:ARBA00007870}.
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DR EMBL; CP023407; AYL38825.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A494UZ13; -.
DR KEGG; sfug:CNQ36_27545; -.
DR Proteomes; UP000282170; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR FunFam; 1.10.1040.10:FF:000017; 2-dehydropantoate 2-reductase; 1.
DR FunFam; 3.40.50.720:FF:000307; 2-dehydropantoate 2-reductase; 1.
DR Gene3D; 1.10.1040.10; N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR013752; KPA_reductase.
DR InterPro; IPR051402; KPR-Related.
DR InterPro; IPR013332; KPR_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR NCBIfam; NF005089; PRK06522.1-4; 1.
DR PANTHER; PTHR21708:SF45; 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR PANTHER; PTHR21708; PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000282170}.
FT DOMAIN 3..104
FT /note="Ketopantoate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02558"
FT DOMAIN 196..314
FT /note="Ketopantoate reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08546"
SQ SEQUENCE 323 AA; 34158 MW; 02CDD150C40E4D49 CRC64;
MKVAVLGAGA IGAYVGAALH RAGADVHLIA RGPHLAAMRQ YGVRVRSPRG DFTARPHATD
DPAEVGPVDY VFLGLKANSY AACGPLIEPL LHGTTAVVAA QNGIPWWYFH RHGGPYDGRR
LESVDPDGAV SAVLAPERAV GCVVYAATEL QEPGVVRHVE GTRFSIGEPG RGVSARCLAL
SEAMRAGGLK CPVEPDLRND IWLKLLGNIS FNPISALVRA TMRQMCLHGG TRQVIETMMT
ETLTVAGALG CDVGVSIERR LAGAEKVGDH RTSTLQDLER GKPLELDVLL AAVVELAEIT
GVPVPTLRTV HALSDLLALR SAA
//
