ID A0A4C1UN21_EUMVA Unreviewed; 136 AA.
AC A0A4C1UN21;
DT 03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 03-JUL-2019, sequence version 1.
DT 18-JUN-2025, entry version 16.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 11 {ECO:0000256|ARBA:ARBA00019621, ECO:0000256|RuleBase:RU364147};
DE AltName: Full=Mediator complex subunit 11 {ECO:0000256|ARBA:ARBA00032011, ECO:0000256|RuleBase:RU364147};
GN Name=MED11 {ECO:0000256|RuleBase:RU364147,
GN ECO:0000313|EMBL:GBP27392.1};
GN ORFNames=EVAR_18869_1 {ECO:0000313|EMBL:GBP27392.1};
OS Eumeta variegata (Bagworm moth) (Eumeta japonica).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Tineoidea;
OC Psychidae; Oiketicinae; Eumeta.
OX NCBI_TaxID=151549 {ECO:0000313|EMBL:GBP27392.1, ECO:0000313|Proteomes:UP000299102};
RN [1] {ECO:0000313|EMBL:GBP27392.1, ECO:0000313|Proteomes:UP000299102}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=31044173; DOI=.1038/s42003-019-0412-8;
RA Kono N., Nakamura H., Ohtoshi R., Tomita M., Numata K., Arakawa K.;
RT "The bagworm genome reveals a unique fibroin gene that provides high
RT tensile strength.";
RL Commun. Biol. 2:148-148(2019).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional pre-initiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364147}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364147}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364147}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 11 family.
CC {ECO:0000256|ARBA:ARBA00008186, ECO:0000256|RuleBase:RU364147}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GBP27392.1}.
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DR EMBL; BGZK01000192; GBP27392.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4C1UN21; -.
DR STRING; 151549.A0A4C1UN21; -.
DR OrthoDB; 5418434at2759; -.
DR Proteomes; UP000299102; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR FunFam; 1.10.287.3490:FF:000001; Mediator of RNA polymerase II transcription subunit 11; 1.
DR Gene3D; 1.10.287.3490; -; 1.
DR InterPro; IPR019404; Mediator_Med11.
DR PANTHER; PTHR22890; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11; 1.
DR Pfam; PF10280; Med11; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU364147};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364147};
KW Reference proteome {ECO:0000313|Proteomes:UP000299102};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364147};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364147}.
FT REGION 112..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 136 AA; 15036 MW; 8E5028EC7C969E11 CRC64;
MAGPMERIQV LDDIEKDIIT CLQCAGQALL ELSKEKSSQK QAETNTSQFL RTLSQVETKL
SDQINYLTQV STGQPHEGSG YASQKVLQMA WHRLEHVRSW VNELDRLRAS HLASSTRTNT
SGVPNGTMTS SGTSTQ
//
