ID A0A4E0QD90_9EURY Unreviewed; 380 AA.
AC A0A4E0QD90;
DT 03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 03-JUL-2019, sequence version 1.
DT 18-JUN-2025, entry version 21.
DE RecName: Full=DNA-directed RNA polymerase subunit Rpo1C {ECO:0000256|HAMAP-Rule:MF_00411};
DE EC=2.7.7.6 {ECO:0000256|HAMAP-Rule:MF_00411};
DE AltName: Full=DNA-directed RNA polymerase subunit A'' {ECO:0000256|HAMAP-Rule:MF_00411};
GN Name=rpoA2 {ECO:0000256|HAMAP-Rule:MF_00411,
GN ECO:0000313|EMBL:TGC11341.1};
GN Synonyms=rpo1C {ECO:0000256|HAMAP-Rule:MF_00411};
GN ORFNames=CUN85_00190 {ECO:0000313|EMBL:TGC11341.1};
OS Methanolobus halotolerans.
OC Archaea; Methanobacteriati; Methanobacteriota; Stenosarchaea group;
OC Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanolobus.
OX NCBI_TaxID=2052935 {ECO:0000313|EMBL:TGC11341.1, ECO:0000313|Proteomes:UP000297295};
RN [1] {ECO:0000313|EMBL:TGC11341.1, ECO:0000313|Proteomes:UP000297295}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SY-01 {ECO:0000313|EMBL:TGC11341.1,
RC ECO:0000313|Proteomes:UP000297295};
RA Shen Y., Huang H.-H., Lai M.-C., Chen S.-C.;
RT "Isolation and Characterization of Methanogenic Archaea from Saline
RT Meromictic Lake at Siberia.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent RNA polymerase (RNAP) catalyzes the
CC transcription of DNA into RNA using the four ribonucleoside
CC triphosphates as substrates. Forms part of the jaw domain.
CC {ECO:0000256|HAMAP-Rule:MF_00411}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) +
CC diphosphate; Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000256|ARBA:ARBA00048552,
CC ECO:0000256|HAMAP-Rule:MF_00411};
CC -!- SUBUNIT: Part of the RNA polymerase complex. {ECO:0000256|HAMAP-
CC Rule:MF_00411}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00411}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC {ECO:0000256|HAMAP-Rule:MF_00411}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TGC11341.1}.
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DR EMBL; PGGK01000001; TGC11341.1; -; Genomic_DNA.
DR RefSeq; WP_135387789.1; NZ_PGGK01000001.1.
DR AlphaFoldDB; A0A4E0QD90; -.
DR OrthoDB; 372142at2157; -.
DR Proteomes; UP000297295; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003899; F:DNA-directed RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:UniProtKB-UniRule.
DR CDD; cd06528; RNAP_A; 1.
DR Gene3D; 1.10.150.390; -; 1.
DR HAMAP; MF_00411; RNApol_arch_Rpo1C; 1.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR012757; RPO1C.
DR NCBIfam; TIGR02389; RNA_pol_rpoA2; 1.
DR PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR PANTHER; PTHR19376:SF32; DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00411};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00411};
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW ECO:0000256|HAMAP-Rule:MF_00411};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695, ECO:0000256|HAMAP-
KW Rule:MF_00411}; Reference proteome {ECO:0000313|Proteomes:UP000297295};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00411};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW Rule:MF_00411}.
FT DOMAIN 37..329
FT /note="RNA polymerase Rpb1"
FT /evidence="ECO:0000259|Pfam:PF04998"
SQ SEQUENCE 380 AA; 41875 MW; 5B3DD879019643B8 CRC64;
MSVSEATIDS MIEPLDLPLN IKRTLRDDAI KVGVTKKELE DIIERLMESY DYACVEPCEA
VGVVSAQSIG EPGTQMTMRT FHYAGVAEIN VTLGLPRLIE IVDARKQPST PMMTIALEEG
CATDRDKARV LAWEIEATHI EHLADITTDL ANMQLIIDLH EKTLTQRSLA ADDIADKLRE
SLDVMVTVSG DIRNQIVVIP NSPSYRELLQ LAKNIHNITL KGIEGIKRVV IRKDGEEYTL
YTEGSQLKEV LQIEGVDVTR TYTNNIGEIY EVFGIEAARN AIITEATDTL GEQGLTVDIR
HIMLVSDIMC SDGEVKQIGR HGISGEKASV FARAAFEVTV SHLLDAGMRG DRDELNGVTE
NIIVGQPIKL GTGDVHLISR
//
