ID A0A4E0QUJ9_9GAMM Unreviewed; 410 AA.
AC A0A4E0QUJ9;
DT 03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 03-JUL-2019, sequence version 1.
DT 02-APR-2025, entry version 26.
DE RecName: Full=Radical SAM core domain-containing protein {ECO:0000259|PROSITE:PS51918};
GN ORFNames=PN36_18795 {ECO:0000313|EMBL:TGO02805.1};
OS Candidatus Thiomargarita nelsonii.
OC Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC Thiotrichales; Thiotrichaceae; Thiomargarita.
OX NCBI_TaxID=1003181 {ECO:0000313|EMBL:TGO02805.1, ECO:0000313|Proteomes:UP000030428};
RN [1] {ECO:0000313|EMBL:TGO02805.1, ECO:0000313|Proteomes:UP000030428}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hydrate Ridge {ECO:0000313|EMBL:TGO02805.1};
RX PubMed=27199933; DOI=10.3389/fmicb.2016.00603;
RA Flood B.E., Fliss P., Jones D.S., Dick G.J., Jain S., Kaster A.K.,
RA Winkel M., Mussmann M., Bailey J.;
RT "Single-Cell (Meta-)Genomics of a Dimorphic Candidatus Thiomargarita
RT nelsonii Reveals Genomic Plasticity.";
RL Front. Microbiol. 7:603-603(2016).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TGO02805.1}.
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DR EMBL; JSZA02000075; TGO02805.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4E0QUJ9; -.
DR Proteomes; UP000030428; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0015995; P:chlorophyll biosynthetic process; IEA:InterPro.
DR GO; GO:0015979; P:photosynthesis; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR CDD; cd21123; SPASM_MftC-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 1.10.8.550; Proto-chlorophyllide reductase 57 kD subunit B; 1.
DR InterPro; IPR023885; 4Fe4S-binding_SPASM_dom.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR013580; LI-POR_suB-like_C.
DR InterPro; IPR042298; P-CP_red_C.
DR InterPro; IPR017200; PqqE-like.
DR InterPro; IPR050377; Radical_SAM_PqqE_MftC-like.
DR InterPro; IPR007197; rSAM.
DR NCBIfam; TIGR04085; rSAM_more_4Fe4S; 1.
DR PANTHER; PTHR11228:SF7; PQQA PEPTIDE CYCLASE; 1.
DR PANTHER; PTHR11228; RADICAL SAM DOMAIN PROTEIN; 1.
DR Pfam; PF08369; PCP_red; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR Pfam; PF13186; SPASM; 1.
DR PIRSF; PIRSF037420; PQQ_syn_pqqE; 1.
DR SFLD; SFLDG01386; main_SPASM_domain-containing; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000030428};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 1..213
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 410 AA; 45342 MW; 4D87CE1603EE2026 CRC64;
MNNLLLLAIN LTRRCNLACQ HCYLDAKTLQ QGSPNELSTE EVCGLLDDIA QRSTETMVVL
TGGEPLVRRD LEILIAHGAK LGLSMVIGTN GVLLTEQRVK SLKKSAVLGV GISLDSLNPT
FHDTFRAVPG AWAKTMAGIE NCRRHALSFQ IHFSVTDNNA DELPAMIDFA RGCGARVFNV
FFLVCTGRGQ FMSDISAARY EEVLKYLIEA QKNNQDIIIR SRCAPHFKRI AYQQHPNSPL
NRISGNEGDG CIAGTHYCRI TPEGGVTACP YIPDELGNIR ENSFWDIWED APVFKALRAP
TLKGKCGVCE YQKLCGGCRA RPLAAGADLM DADLLCTYQP QGEPVIQPLQ NLSIQWSLEA
EQRMERIPAF LRQMVKKRAE AYVAELGQDI VTPEHLAVLS ARRFGAPKRL
//
