ID   A0A4E0R2W8_FASHE        Unreviewed;       446 AA.
AC   A0A4E0R2W8;
DT   03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT   03-JUL-2019, sequence version 1.
DT   28-JAN-2026, entry version 15.
DE   SubName: Full=Choline/ethanolamine kinase {ECO:0000313|EMBL:THD21843.1};
GN   ORFNames=D915_007237 {ECO:0000313|EMBL:THD21843.1};
OS   Fasciola hepatica (Liver fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Plagiorchiida; Echinostomata; Echinostomatoidea; Fasciolidae;
OC   Fasciola.
OX   NCBI_TaxID=6192 {ECO:0000313|EMBL:THD21843.1, ECO:0000313|Proteomes:UP000230066};
RN   [1] {ECO:0000313|EMBL:THD21843.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Choi Y.-J., Martin J., Mitreva M.;
RT   "Improved annotation for the trematode Fasciola hepatica.";
RL   Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the choline/ethanolamine kinase family.
CC       {ECO:0000256|ARBA:ARBA00038211}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:THD21843.1}.
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DR   EMBL; JXXN02003207; THD21843.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A4E0R2W8; -.
DR   Proteomes; UP000230066; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR   GO; GO:0004103; F:choline kinase activity; IEA:TreeGrafter.
DR   GO; GO:0004305; F:ethanolamine kinase activity; IEA:TreeGrafter.
DR   GO; GO:0006646; P:phosphatidylethanolamine biosynthetic process; IEA:TreeGrafter.
DR   Gene3D; 3.90.1200.10; -; 1.
DR   Gene3D; 3.30.200.20; Phosphorylase Kinase, domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   PANTHER; PTHR22603; CHOLINE/ETHANOALAMINE KINASE; 1.
DR   PANTHER; PTHR22603:SF93; RE24176P; 1.
DR   Pfam; PF01633; Choline_kinase; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE   3: Inferred from homology;
KW   Kinase {ECO:0000313|EMBL:THD21843.1};
KW   Lipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023209};
KW   Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW   Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW   Reference proteome {ECO:0000313|Proteomes:UP000230066};
KW   Transferase {ECO:0000313|EMBL:THD21843.1}.
FT   REGION          359..380
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        359..376
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   446 AA;  51615 MW;  BEBA554AE7AEE66E CRC64;
     MFFTHSIDDE VLDEVPCPDF IPQVSQRVAD RVTDCVITRL RKQCGKSLAG SWADPENVIV
     EKMNTCGLSN YLYMAQLKSH VPVQPEEPRK VLIRVYGEVL RSSVDSIVLD SINFAILSEK
     RIGPALYGVF PGGRIEEFIE SRTMTTSELR KSEAMKAVAQ QLARIHNLNM PFCKQPRFIF
     KMMDKFLAQL SGRMDPPSRP PPNLSTPTLL VLEQEYLSDS RLDSVWNMDN FEAIQHTATE
     LGLYKEYEWL KQNLIERQDD AFPVVFCHND FQENNILVLN NPDVDGFYDV LPIDFEYSGY
     NFRGFDIGNH FNEWCYDYTC PDPPYFTYDF DSYPTLSQQK EFWNTYLTAR ITERRTSIDT
     SKSAGDTLNG SSTTTPHPLE DTKEDFEKLW LEATFGALFS HLFWAAWSLI QSQISSIRFE
     FSKYASARMD AYYRMKNSLK SRPDYQ
//