ID A0A4E0RXV8_FASHE Unreviewed; 239 AA.
AC A0A4E0RXV8;
DT 03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 03-JUL-2019, sequence version 1.
DT 05-FEB-2025, entry version 18.
DE RecName: Full=ADP-ribosylation factor-like protein 2-binding protein {ECO:0000256|ARBA:ARBA00014849, ECO:0000256|RuleBase:RU367099};
DE Short=ARF-like 2-binding protein {ECO:0000256|RuleBase:RU367099};
GN ORFNames=D915_005754 {ECO:0000313|EMBL:THD23342.1};
OS Fasciola hepatica (Liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Plagiorchiida; Echinostomata; Echinostomatoidea; Fasciolidae;
OC Fasciola.
OX NCBI_TaxID=6192 {ECO:0000313|EMBL:THD23342.1, ECO:0000313|Proteomes:UP000230066};
RN [1] {ECO:0000313|EMBL:THD23342.1, ECO:0000313|Proteomes:UP000230066}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Choi Y.-J., Martin J., Mitreva M.;
RT "Improved annotation for the trematode Fasciola hepatica.";
RL Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role as an effector of the ADP-ribosylation factor-
CC like protein 2, ARL2. {ECO:0000256|RuleBase:RU367099}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC {ECO:0000256|ARBA:ARBA00004120, ECO:0000256|RuleBase:RU367099}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC {ECO:0000256|ARBA:ARBA00004300, ECO:0000256|RuleBase:RU367099}.
CC Cytoplasm {ECO:0000256|RuleBase:RU367099}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU367099}.
CC Mitochondrion intermembrane space {ECO:0000256|RuleBase:RU367099}.
CC -!- SIMILARITY: Belongs to the ARL2BP family.
CC {ECO:0000256|ARBA:ARBA00009880, ECO:0000256|RuleBase:RU367099}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:THD23342.1}.
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DR EMBL; JXXN02002198; THD23342.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4E0RXV8; -.
DR Proteomes; UP000230066; Unassembled WGS sequence.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-UniRule.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0051457; P:maintenance of protein location in nucleus; IEA:TreeGrafter.
DR Gene3D; 1.20.1520.10; ADP-ribosylation factor-like 2-binding protein, domain; 1.
DR InterPro; IPR038849; ARL2BP.
DR InterPro; IPR023379; BART_dom.
DR InterPro; IPR042541; BART_sf.
DR PANTHER; PTHR15487; ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-BINDING PROTEIN; 1.
DR PANTHER; PTHR15487:SF4; ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-BINDING PROTEIN; 1.
DR Pfam; PF11527; ARL2_Bind_BART; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273,
KW ECO:0000256|RuleBase:RU367099};
KW Cilium {ECO:0000256|ARBA:ARBA00023069, ECO:0000256|RuleBase:RU367099};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU367099};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|RuleBase:RU367099};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128,
KW ECO:0000256|RuleBase:RU367099}; Nucleus {ECO:0000256|RuleBase:RU367099};
KW Reference proteome {ECO:0000313|Proteomes:UP000230066}.
FT DOMAIN 37..148
FT /note="BART"
FT /evidence="ECO:0000259|Pfam:PF11527"
SQ SEQUENCE 239 AA; 27019 MW; BBFEFD5BDAD2D0F2 CRC64;
MAPMEHGDVI LDTACTDDTE GNEEILAGQL NVAASVFDQT VGYLEDIMIS DEFQETQDRF
MNENCYTFEE TDENKLCYTE IHQNYITMIE NLLERELKKR TPKFSMATFM SELKKHQTEL
DGEVFEMLYT LTDFVLFKEM MIDYKKAKTG DTVNLELTNS YFSCPATRAD PMLLLNHNSG
DKENFCSGKT LNDTAMHTEN ANLESSAVAR LISLNLDDNE NPALSDAHGS ADEVHNSGI
//
