ID A0A4E9FM88_BRUMA Unreviewed; 1195 AA.
AC A0A4E9FM88; A0A8L7TH74;
DT 11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 1.
DT 28-JAN-2026, entry version 26.
DE SubName: Full=Collagenase NC10 and Endostatin family protein {ECO:0000313|EMBL:VIO97439.1, ECO:0000313|WBParaSite:Bm8092a.1};
GN Name=Bm8092 {ECO:0000313|EMBL:VIO97439.1};
GN ORFNames=BM_BM8092 {ECO:0000313|EMBL:VIO97439.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:VIO97439.1};
RN [1] {ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:VIO97439.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FR3 {ECO:0000313|EMBL:VIO97439.1};
RA Howe K., Paulini M., Williams G.;
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm8092a.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2022) to UniProtKB.
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DR EMBL; CAAKNF010000194; VIO97439.1; -; Genomic_DNA.
DR RefSeq; XP_042937046.1; XM_043081112.1.
DR AlphaFoldDB; A0A4E9FM88; -.
DR GeneID; 6095261; -.
DR KEGG; bmy:BM_BM8092; -.
DR WBParaSite; Bm8092a.1; Bm8092a.1; WBGene00228353.
DR CTD; 6095261; -.
DR OrthoDB; 5983381at2759; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0031012; C:extracellular matrix; IEA:TreeGrafter.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0030020; F:extracellular matrix structural constituent conferring tensile strength; IEA:TreeGrafter.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:TreeGrafter.
DR Gene3D; 3.40.1620.70; -; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR050149; Collagen_superfamily.
DR InterPro; IPR010515; Collagenase_NC10/endostatin.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR045463; XV/XVIII_trimerization_dom.
DR PANTHER; PTHR24023:SF1112; COL_CUTICLE_N DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR Pfam; PF01391; Collagen; 2.
DR Pfam; PF20010; Collagen_trimer; 1.
DR Pfam; PF06482; Endostatin; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
PE 4: Predicted;
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Reference proteome {ECO:0000313|Proteomes:UP000006672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 694..739
FT /note="Collagen type XV/XVIII trimerization"
FT /evidence="ECO:0000259|Pfam:PF20010"
FT DOMAIN 1012..1177
FT /note="Collagenase NC10/endostatin"
FT /evidence="ECO:0000259|Pfam:PF06482"
FT REGION 100..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 279..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 440..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 596..621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 637..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 857..938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 964..994
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..116
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 449..458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..477
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..511
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..522
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..561
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 651..678
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 874..892
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 910..927
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 972..994
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1195 AA; 132766 MW; 9AC68EEF925CC40A CRC64;
MKSYQLLLLS NHILRIFFLF SALIITINTK QAEDIHHSSV VDFKIHIDKF KNQNSKNHDT
GNYHQLVSTI AKSGLSKKFE DLVTDEGFIL TALKQQQRQQ RQRQRQQQQQ QGQQQNENEK
GVNNEGNSAV ATTTATTIII ESANSTITDK QNLSIVGTNF IDFSYPTNNP VNKEISLAIH
SISNNSNLFQ SLINQSIRND NNGDSSSSSN SKDSSSNIKW KFLNQRMINL NDGDSNHRRK
RWATDDTSDK DEMNKIFDTL SSTNYDSPTS ASDEMLTSSD YHIHDNGDDD DVDKSDNTDD
SRFRIPVENI VIMGSDADAD VDDSSSDNNG MFKGTTFDEI ETTDSYEQMN SVEETEKDDE
NMEMGIVRIA PEILPKDSIE NLMEPTMHQF GLEAKTDEIM DEKLLKSDII GRKNHMGKED
EIDWEGSGVQ DEELQEYEKT GKTTIAVPEQ SSIHTSSDYP RVKPEKGEKG DKGDRGEPGP
PGEPGTCPIE CQPGRDGRDG IPGMPGEMGP MGPIGPPGPA GPPGLSTQIV QEGPQGVRTV
AGPTGPQGPP GPMGPRGPPG PRGVGEPGFP GAPGVPGRCE RLHPEDIERI VSDPRIKGEK
GDCLPGIPIR HPGESKELPP YDSYQRHYAM KGERGERGEI GRMGPMGPIG HPGPPGPPGP
PGPPGPPGPP GHPGPAGPPL AAYPQPTHIA PGGVQVYPTT IELFTASHGM PIGSLTFCIS
SQQLYIRVNG GFKDIKLEGF HPIMERRPTV DESSKSEVQY QIPLMSNDDS LIPSQVSLSH
HRISPKLNIP QKNQHLISDT YDKQSRTADI IHRPQIFDAS QSIKSYQQHH KSLLSSEITP
STFSNQQSWQ TFESKHHLSY PRTEYRPPAG QLYPRYRLPS GSSGSSGLSR LSPNERLHKS
HHLSQRLDHT PSTLQSFPSS QHISVQHQRI EHQNPSVKPD YHSEHIALAT VATTFSPEWS
KQQATISLPD EQEAHRSRYP DHERLRYRER PGPDRTHSAL LPHSLQAKDL VLHLIALNTP
MSGNMRGVRG ADLACYQQAR QANFRTTFRA FLSSHVQDLN KVVHSGDRDT PVVNLRGERL
FDSWSDIFQQ RQMADLPIYS FNRRNVFADS IWPEKRIWHG SDLSGMRSES GYCSAWRSAS
TTQVGRASFI GRGLPLLRDS RDSECSRELV VLCIENMSKY NADKRLGKKR AYFSE
//
