ID   A0A4Q4TJF8_9PEZI        Unreviewed;       782 AA.
AC   A0A4Q4TJF8;
DT   31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT   31-JUL-2019, sequence version 1.
DT   05-FEB-2025, entry version 19.
DE   RecName: Full=Anaphase-promoting complex subunit 5 {ECO:0000256|ARBA:ARBA00016066};
DE   AltName: Full=Cyclosome subunit 5 {ECO:0000256|ARBA:ARBA00031069};
GN   ORFNames=DL764_002692 {ECO:0000313|EMBL:RYP07145.1};
OS   Monosporascus ibericus.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Xylariomycetidae; Xylariales; Xylariales incertae sedis; Monosporascus.
OX   NCBI_TaxID=155417 {ECO:0000313|EMBL:RYP07145.1, ECO:0000313|Proteomes:UP000293360};
RN   [1] {ECO:0000313|EMBL:RYP07145.1, ECO:0000313|Proteomes:UP000293360}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 110550 {ECO:0000313|EMBL:RYP07145.1,
RC   ECO:0000313|Proteomes:UP000293360};
RA   Robinson A.J., Natvig D.O.;
RT   "Complete Genomes of Monosporascus.";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC       (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls
CC       progression through mitosis and the G1 phase of the cell cycle. The
CC       APC/C complex acts by mediating ubiquitination and subsequent
CC       degradation of target proteins: it mainly mediates the formation of
CC       'Lys-11'-linked polyubiquitin chains and, to a lower extent, the
CC       formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The
CC       APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked
CC       branched ubiquitin chains on target proteins.
CC       {ECO:0000256|ARBA:ARBA00045696}.
CC   -!- SIMILARITY: Belongs to the APC5 family.
CC       {ECO:0000256|ARBA:ARBA00007450}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RYP07145.1}.
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DR   EMBL; QJNU01000104; RYP07145.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A4Q4TJF8; -.
DR   STRING; 155417.A0A4Q4TJF8; -.
DR   OrthoDB; 2504561at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000293360; Unassembled WGS sequence.
DR   GO; GO:0005680; C:anaphase-promoting complex; IEA:InterPro.
DR   GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IEA:TreeGrafter.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0045842; P:positive regulation of mitotic metaphase/anaphase transition; IEA:TreeGrafter.
DR   GO; GO:0070979; P:protein K11-linked ubiquitination; IEA:TreeGrafter.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR037679; Apc5.
DR   InterPro; IPR026000; Apc5_dom.
DR   InterPro; IPR006595; CTLH_C.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR12830; ANAPHASE-PROMOTING COMPLEX SUBUNIT 5; 1.
DR   PANTHER; PTHR12830:SF9; ANAPHASE-PROMOTING COMPLEX SUBUNIT 5; 1.
DR   Pfam; PF12862; ANAPC5; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50897; CTLH; 1.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW   Reference proteome {ECO:0000313|Proteomes:UP000293360};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          571..629
FT                   /note="CTLH"
FT                   /evidence="ECO:0000259|PROSITE:PS50897"
FT   COILED          584..611
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   782 AA;  88881 MW;  12E63602E86C701A CRC64;
     MSRFLNPAKI CLLALIELYT NKTVPTSSIV QILSFITSHL IDYDLSNAPG DCEGRWKRAE
     ITVSLVVSIT DFEKVLTPHT AASGMPGRSL WYVFLDKLWK IDSLDALHAF FERCSELLAK
     TKEELRRDAE MGTPAPGPEV ILLSRNSPFG AFVRRSQLEF TRLRFQDAFE LWKNFVKYRQ
     TTAAYYRKKT PSFQRLSFDN VLLAGEHDWG GGVEAVASVA YGDMLMDDPT MMLPVSTDDI
     EKLLEFQIDQ MQKYGNRIPL EIRHQFQDLL NDSFMVPSLS HYLSYLDAWR AGDYSTSFDY
     LHRYFDYTMQ NRDRLFYQYA LMNLAVLQAD FGCHKEAVAA MLETVSTARE NRDMTCLNFA
     LNWLFHFGRT HPEVTKELES NSMLGTGKES LAFLRSKAKE TGMWSLWGSA LMSEAKMSLS
     NGESLATALE HMVRSSQILV ERNMKSMMGS QLSLNIALWD RLGIAYLSST ACEVFLRCHA
     RHSIFDDELK VTSRQASMLA LKGKYDEALG RLERMDANAL RAWKPNQYWH KFRGIIKLRR
     DLHRNDLDGA ELLLSQLLQS KNEDLEPDLA FVVDSLHIEC LVRRGDLERA LAKLENLILE
     LRDENKDVAL RVRLLLIKAE LLDKCGRPQK GFTIAVRAAN VAWHARLIPY LWPAVGAIAN
     ILSSLGEFEP AIQLLNTILP RSLECENSAM IAQLYSHLAD ANMGMAGKNQ PRSNKRREFM
     TKAVGALEKA FDHYSSIEDV NKQCEMVAKK ATIMKVAGDN VLANDYAAAY LALRREAAQS
     RI
//