ID A0A4Q7J053_9PSEU Unreviewed; 325 AA.
AC A0A4Q7J053;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 18-JUN-2025, entry version 19.
DE SubName: Full=2-dehydropantoate 2-reductase {ECO:0000313|EMBL:RZQ59743.1};
GN ORFNames=EWH70_31940 {ECO:0000313|EMBL:RZQ59743.1};
OS Amycolatopsis suaedae.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Amycolatopsis.
OX NCBI_TaxID=2510978 {ECO:0000313|EMBL:RZQ59743.1, ECO:0000313|Proteomes:UP000292003};
RN [1] {ECO:0000313|EMBL:RZQ59743.1, ECO:0000313|Proteomes:UP000292003}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=8-3EHSu {ECO:0000313|EMBL:RZQ59743.1,
RC ECO:0000313|Proteomes:UP000292003};
RA Duangmal K., Chantavorakit T.;
RT "Draft genome sequence of Amycolatopsis sp. 8-3EHSu isolated from roots of
RT Suaeda maritima.";
RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ketopantoate reductase family.
CC {ECO:0000256|ARBA:ARBA00007870}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RZQ59743.1}.
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DR EMBL; SFCC01000021; RZQ59743.1; -; Genomic_DNA.
DR RefSeq; WP_130479308.1; NZ_SFCC01000021.1.
DR AlphaFoldDB; A0A4Q7J053; -.
DR OrthoDB; 9796561at2; -.
DR Proteomes; UP000292003; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR FunFam; 1.10.1040.10:FF:000017; 2-dehydropantoate 2-reductase; 1.
DR FunFam; 3.40.50.720:FF:000307; 2-dehydropantoate 2-reductase; 1.
DR Gene3D; 1.10.1040.10; N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR013752; KPA_reductase.
DR InterPro; IPR051402; KPR-Related.
DR InterPro; IPR013332; KPR_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR NCBIfam; NF005089; PRK06522.1-4; 1.
DR PANTHER; PTHR21708:SF45; 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR PANTHER; PTHR21708; PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000292003}.
FT DOMAIN 3..104
FT /note="Ketopantoate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02558"
FT DOMAIN 196..315
FT /note="Ketopantoate reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08546"
SQ SEQUENCE 325 AA; 34688 MW; 7B63FADAD47AE863 CRC64;
MKVAVVGAGA IGAYVGAHLH RAGVEVHLIA RNAHLHAMRS NGIRVLSARG DFEARPHATD
DPSSIGPVDH VFLGLKANSY AAAGPMIQGL LHDKTTIIAA QNGIPWWYFH RLPGPYENQR
INSVDPDGAV SAVLPVERAI GCVVYAATEI TEPGVVTHLE GTRFTIGEPD GSISSRCTEF
ADAMIAGGLK CPVEPDVRRD IWLKLMGNIA FNPISALARA TMAGICRHGG TRELVVRMMQ
ETLDVATKLG ARPEISIERR LAGAERAGEH KTSTLQDLEK GRPMELDVLL QAVVELADLT
GTEVPTVRAV CALADLLNAQ LAKTA
//
