ID A0A4Q9KIW8_9ACTN Unreviewed; 590 AA.
AC A0A4Q9KIW8;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 28-JAN-2026, entry version 26.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:TBT88546.1};
GN ORFNames=ET989_00915 {ECO:0000313|EMBL:TBT88546.1};
OS Propioniciclava sinopodophylli.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Propionibacteriaceae; Propioniciclava.
OX NCBI_TaxID=1837344 {ECO:0000313|EMBL:TBT88546.1, ECO:0000313|Proteomes:UP000292373};
RN [1] {ECO:0000313|EMBL:TBT88546.1, ECO:0000313|Proteomes:UP000292373}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KCTC 33808 {ECO:0000313|EMBL:TBT88546.1,
RC ECO:0000313|Proteomes:UP000292373};
RA Huptas C., Wenning M., Breitenwieser F., Doll E., Von Neubeck M.,
RA Busse H.-J., Scherer S.;
RT "Lactibacter flavus gen. nov., sp. nov., a novel bacterium of the family
RT Propionibacteriaceae isolated from raw milk and dairy products.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TBT88546.1}.
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DR EMBL; SDMQ01000001; TBT88546.1; -; Genomic_DNA.
DR RefSeq; WP_131166676.1; NZ_SDMQ01000001.1.
DR AlphaFoldDB; A0A4Q9KIW8; -.
DR OrthoDB; 9803139at2; -.
DR Proteomes; UP000292373; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:TBT88546.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000292373}.
FT DOMAIN 1..165
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 590 AA; 62025 MW; 18F9B856C71C1EDC CRC64;
MRVIATAGHV DHGKSTLVRA LTGTDPDRWA EEHRRGLTLD LGYAWTSLPG GETVAFVDVP
GHQRFIATML AGLGPAPGVL FVVAADEGWR RQSTEHLAAV RALGIEHVVV AVSRADLADP
AEAARQVRER LGDVPLVAVS AVTGQGLDDL RAALDQLCVR LPDPVTTGRV RLWVDRVFTM
KGAGTIATGT LESGRIAVGD TVQLQRAEGA TTATVRGLQA LGVPHPEVPA VARVAVNLRG
VTTGDLARGD TLLTPGAWHR TTSVDARLLA PDDVPEHLTL HVGTVAVPAR VRPLGGDAVR
LTWPHPLPLQ VGDRLVLRDP GRHHIVAGAQ VLDADPPALR RRGAARERAS ALATRGATLD
VAAEVDRRGW ARASDLLALG ATAEALADAG VREYRGVLVS PEQWADWTQA LGEVVRATVE
ADPLQARMPA GAAASALGLP TADLVGPLAS DAGLQLVAGH VEVPGRRADL GAAEAGLDAL
EQRLAQRPFA APEADDLQAA GLGPRQVAAA VRLGRVLDLG GHVLVLPTAP ALARRRLAAL
PQPFTTSQAR QALDTTRRVV IPLLTELDRR GWTRRIDAGH REVARPGGTP
//
