ID A0A4R2C9Z5_9ACTN Unreviewed; 353 AA.
AC A0A4R2C9Z5;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 18-JUN-2025, entry version 18.
DE SubName: Full=2-dehydropantoate 2-reductase {ECO:0000313|EMBL:TCN35544.1};
GN ORFNames=EV642_116108 {ECO:0000313|EMBL:TCN35544.1};
OS Kribbella sp. VKM Ac-2500.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Kribbellaceae; Kribbella.
OX NCBI_TaxID=2512214 {ECO:0000313|EMBL:TCN35544.1, ECO:0000313|Proteomes:UP000295820};
RN [1] {ECO:0000313|EMBL:TCN35544.1, ECO:0000313|Proteomes:UP000295820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM Ac-2500 {ECO:0000313|EMBL:TCN35544.1,
RC ECO:0000313|Proteomes:UP000295820};
RX PubMed=26203337; DOI=.1186/s40793-015-0017-x;
RA Whitman W.B., Woyke T., Klenk H.P., Zhou Y., Lilburn T.G., Beck B.J.,
RA De Vos P., Vandamme P., Eisen J.A., Garrity G., Hugenholtz P.,
RA Kyrpides N.C.;
RT "Genomic Encyclopedia of Bacterial and Archaeal Type Strains, Phase III:
RT the genomes of soil and plant-associated and newly described type
RT strains.";
RL Stand. Genomic Sci. 10:26-26(2015).
CC -!- SIMILARITY: Belongs to the ketopantoate reductase family.
CC {ECO:0000256|ARBA:ARBA00007870}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TCN35544.1}.
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DR EMBL; SLVW01000016; TCN35544.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4R2C9Z5; -.
DR OrthoDB; 9796561at2; -.
DR Proteomes; UP000295820; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR FunFam; 1.10.1040.10:FF:000017; 2-dehydropantoate 2-reductase; 1.
DR FunFam; 3.40.50.720:FF:000307; 2-dehydropantoate 2-reductase; 1.
DR Gene3D; 1.10.1040.10; N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR013752; KPA_reductase.
DR InterPro; IPR051402; KPR-Related.
DR InterPro; IPR013332; KPR_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR NCBIfam; NF005089; PRK06522.1-4; 1.
DR PANTHER; PTHR21708:SF45; 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR PANTHER; PTHR21708; PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000295820}.
FT DOMAIN 3..104
FT /note="Ketopantoate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02558"
FT DOMAIN 196..314
FT /note="Ketopantoate reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08546"
SQ SEQUENCE 353 AA; 37113 MW; DAC09604A3C96E42 CRC64;
MRVAVLGAGA IGAYVGAALH RGGTEVHLVA RGPHLEAIRK NGVQVLSPRG DWLAKTPATD
DPAEIGPVDF VFLGLKANSY ASCGPLIEPL LHDKTAVVAA QNGIPWWYFH GLSGPHEGRR
IESVDPGGEV TRVLPLERAI GCVVYCSTEL EGPGLVRHLE GTRFSIGEPG GGRSDRCLEF
SEAMIAGGLK CPVEEDVRND IWIKLLGNAA FNPISALARA TMVEIAQHSG TRAMIRLMME
ETLEIAAAVG SHPDISVDKR IDGAERVGEH KTSMLQDLEK DKPLELDVIL AAVVELADLT
DTKAPTLRAV HAVADLLSTK VGLAPIAHAP TAAPAPSTAA PAAVVPAVSS PRA
//
