ID A0A4R2P7L2_9BACL Unreviewed; 637 AA.
AC A0A4R2P7L2;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 28-JAN-2026, entry version 26.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=EV207_1067 {ECO:0000313|EMBL:TCP30184.1};
OS Scopulibacillus darangshiensis.
OC Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Sporolactobacillaceae;
OC Scopulibacillus.
OX NCBI_TaxID=442528 {ECO:0000313|EMBL:TCP30184.1, ECO:0000313|Proteomes:UP000295416};
RN [1] {ECO:0000313|EMBL:TCP30184.1, ECO:0000313|Proteomes:UP000295416}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19377 {ECO:0000313|EMBL:TCP30184.1,
RC ECO:0000313|Proteomes:UP000295416};
RA Goeker M.;
RT "Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing the
RT most valuable type-strain genomes for metagenomic binning, comparative
RT biology and taxonomic classification.";
RL Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TCP30184.1}.
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DR EMBL; SLXK01000006; TCP30184.1; -; Genomic_DNA.
DR RefSeq; WP_132744709.1; NZ_SLXK01000006.1.
DR AlphaFoldDB; A0A4R2P7L2; -.
DR OrthoDB; 9804504at2; -.
DR Proteomes; UP000295416; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:TCP30184.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000295416}.
FT DOMAIN 12..185
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 637 AA; 71360 MW; 881E926102A1CC87 CRC64;
MANTIGEIDM LKHDMTIGLA GHIDHGKTSL TKALTDIETD RLKEEQTRNI SIENGFAYLD
LEDQRRAAII DVPGHERFIR QMIAGVAGID LVILVIAADE GVMPQTEEHI DILTLLGIKQ
ALIVLTKIGV VDDEWLAMVE EDVSSYLKKT SFADAPIYKV DSVSGKGIAL LKDAINAASH
EIRAKNPNEP FRMPIDDVFT LHGLGTIVRG TIFNGQVHKD DNLMLLPKGQ KVKVKSLQIH
HKDTSIASSG QRAAMNIGGL SRDDVKRGDV LVSDGTIYMP SSRLDVQLKI LNNIDRPFKQ
RSPVICHLGT AAVMGKLIMF DRNKCEAGDD LYCQIELAAP LTAKKGDRFI VRRPTPAETI
GGGQVIDVEA VKHRFGEGTI KLLERKAQGA PADLVYQYLV EFEEATERDL LRSTGLPNDL
LIQILNDTLE RRVIARLSHN TYVLNDRLNQ AQGLLLENLK AYHQDYPMRQ GLSKADLLRS
LPFGEALQSK VYERLKESNE LESHDHMVKL SDFTPHFPDQ WARRMTGVVN DLAKQGLKPV
SWSELADESG IPAGLQKDLK DYLLSVGKTM LLEEDLLMHH QAFCDAVKRL RQKSNEAFTI
QDAKAVLDLS RKYLIPFLEC CDREGYTVRE NNKRRWK
//
