ID A0A4R5AW23_9ACTN Unreviewed; 580 AA.
AC A0A4R5AW23;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 28-JAN-2026, entry version 19.
DE SubName: Full=Selenocysteine-specific translation elongation factor {ECO:0000313|EMBL:TDD74822.1};
GN ORFNames=E1293_29035 {ECO:0000313|EMBL:TDD74822.1};
OS Actinomadura darangshiensis.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Thermomonosporaceae; Actinomadura.
OX NCBI_TaxID=705336 {ECO:0000313|EMBL:TDD74822.1, ECO:0000313|Proteomes:UP000295578};
RN [1] {ECO:0000313|EMBL:TDD74822.1, ECO:0000313|Proteomes:UP000295578}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45941 {ECO:0000313|EMBL:TDD74822.1,
RC ECO:0000313|Proteomes:UP000295578};
RA Sahin N., Ay H., Saygin H.;
RT "Draft genome sequences of novel Actinobacteria.";
RL Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TDD74822.1}.
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DR EMBL; SMKY01000162; TDD74822.1; -; Genomic_DNA.
DR RefSeq; WP_132200673.1; NZ_SMKY01000162.1.
DR AlphaFoldDB; A0A4R5AW23; -.
DR OrthoDB; 9803139at2; -.
DR Proteomes; UP000295578; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0035368; F:selenocysteine insertion sequence binding; IEA:TreeGrafter.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0000049; F:tRNA binding; IEA:TreeGrafter.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:TreeGrafter.
DR GO; GO:0016259; P:selenocysteine metabolic process; IEA:TreeGrafter.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050543; eIF2G.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR42854; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER; 1.
DR PANTHER; PTHR42854:SF3; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
PE 4: Predicted;
KW Elongation factor {ECO:0000313|EMBL:TDD74822.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000295578}.
FT DOMAIN 38..149
FT /note="Tr-type G"
FT /evidence="ECO:0000259|Pfam:PF00009"
FT DOMAIN 267..326
FT /note="Selenocysteine-specific elongation factor beta-
FT barrel"
FT /evidence="ECO:0000259|Pfam:PF25461"
SQ SEQUENCE 580 AA; 60019 MW; E4A45D15E8C4967C CRC64;
MQVVTTAGHG GHGKSALVRA LTGKEPGEPA AWTELPSGRR VAFVDVPGDE RSVPAMLAAA
APAPAALLAV AADEGWMPQT REHLDALGAL GVRSGVLAVT KADAADGRLA LRLIRERLAG
TALQGAEAVA VSAATGAGMA ELAAALDRLA GRLPVPDPAA PVRLWVDRAF TAGRQSVVTG
TLAAGTVAVG DELLLMPGGG GVRVRTIGCA GEPRDSVGGV SRVVLTLRDA GRVDAGMALV
TPGAWTHTTS VDVRTRFGEA SGRLARALTL HLGAAAVPVR LRPLGPDTAR LTLNTRLALH
LGDTGVLRDP ERRSIAGVSV LDVRPPTLVR RGAGAARARE LASWPDRPDG TIVLRRHGVL
RRTELSLMGC APPPDAVALN GEWVADPAHW RSLFERLAEE TARHAAQSPH APGIPLETVR
LRLGLPARQL VAALVRPPLR VDAGRVYGPA AEDAAPPEPP AEPPPPPWTA AVERLRADLA
AAPFEPPAAE RLEALGLTGD VLDGAERAGA VLRIRDGGGD GGGDIVLLPG ADREALRVLS
GLPQPFTPAD AGRALSTNRD VAIALLRHLD GLGLTERRRS
//
