ID A0A4R5QDI5_9PROT Unreviewed; 639 AA.
AC A0A4R5QDI5;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 28-JAN-2026, entry version 24.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:TDH60873.1};
GN ORFNames=E2C06_19840 {ECO:0000313|EMBL:TDH60873.1};
OS Dankookia rubra.
OC Bacteria; Pseudomonadati; Pseudomonadota; Alphaproteobacteria;
OC Acetobacterales; Roseomonadaceae; Dankookia.
OX NCBI_TaxID=1442381 {ECO:0000313|EMBL:TDH60873.1, ECO:0000313|Proteomes:UP000295096};
RN [1] {ECO:0000313|EMBL:TDH60873.1, ECO:0000313|Proteomes:UP000295096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM30602 {ECO:0000313|EMBL:TDH60873.1,
RC ECO:0000313|Proteomes:UP000295096};
RX PubMed=27225458; DOI=10.1007/s12275-016-6054-3;
RA Kim W.H., Kim D.H., Kang K., Ahn T.Y.;
RT "Dankookia rubra gen. nov., sp. nov., an alphaproteobacterium isolated from
RT sediment of a shallow stream.";
RL J. Microbiol. 54:420-425(2016).
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TDH60873.1}.
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DR EMBL; SMSJ01000030; TDH60873.1; -; Genomic_DNA.
DR RefSeq; WP_133290351.1; NZ_SMSJ01000030.1.
DR AlphaFoldDB; A0A4R5QDI5; -.
DR OrthoDB; 9804504at2; -.
DR Proteomes; UP000295096; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004020; F:adenylylsulfate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR PANTHER; PTHR43721:SF11; SELENOCYSTEINE-SPECIFIC ELONGATION FACTOR; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:TDH60873.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000295096}.
FT DOMAIN 1..173
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 639 AA; 66485 MW; 257C0ADBEE10881D CRC64;
MTILAIGVMG HVDHGKTALV RALTGTDTDR LPEEKARGIS IALGFALLRV GEAEIDLIDM
PGHERFLRTM VAGAAGIGAV LVVVSALEGP RAQTREHLEI AGLLGLRRAV VAVSFCDRAT
PDQARLAGVS TAALAIQAGL QAPPVLLTAA RTGLGVTELA AALADLARAV PPPIDLGLAQ
LPVDRAFALP GIGPVVTGTL RRGRLAVGEE VELNPGGRPV RVRSLQVHGK PVAAAPPGRR
VAVALRGVEI GALSRGMVLA SPGAARPGEW LDARLEVLGS ALAPVADGAT LRLLTGTMEV
AARLRLPTGG VLPPGEAALV QLRCDPPVVA MAGDGFVLRL ASPSRSIGGG VILDPGAVRR
RRTDRAALPR LEAAAAGDWA EATLCLLREC GGARPQEWVP RLGHAAAQLR RWALAGGARE
VADGTLLHPG TWESILSGLR ATLAAFHAAQ PMEAGMRPEA LRATLPAGLA DAAAAALVEA
AGLRRDPDGL LRLPDFDPVQ AMAAEARGLT VGLAALFRRA GLSPPDAAAV VAGDRTRAEA
LRFLLQRGVL VRATDTVQHR FILFHRDAVA EAQRRLAGAL DRPEGFAVGE AGALLGISRK
FSIPLLEHLD SLRFTRRAGD RRYIEGDAAA RRSAAEMAR
//
