ID A0A4R5QL94_9PROT Unreviewed; 325 AA.
AC A0A4R5QL94;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 18-JUN-2025, entry version 18.
DE RecName: Full=2-dehydropantoate 2-reductase {ECO:0000256|ARBA:ARBA00019465};
DE EC=1.1.1.169 {ECO:0000256|ARBA:ARBA00013014};
DE AltName: Full=Ketopantoate reductase {ECO:0000256|ARBA:ARBA00032024};
GN ORFNames=E2C06_02805 {ECO:0000313|EMBL:TDH64284.1};
OS Dankookia rubra.
OC Bacteria; Pseudomonadati; Pseudomonadota; Alphaproteobacteria;
OC Acetobacterales; Roseomonadaceae; Dankookia.
OX NCBI_TaxID=1442381 {ECO:0000313|EMBL:TDH64284.1, ECO:0000313|Proteomes:UP000295096};
RN [1] {ECO:0000313|EMBL:TDH64284.1, ECO:0000313|Proteomes:UP000295096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM30602 {ECO:0000313|EMBL:TDH64284.1,
RC ECO:0000313|Proteomes:UP000295096};
RX PubMed=27225458; DOI=10.1007/s12275-016-6054-3;
RA Kim W.H., Kim D.H., Kang K., Ahn T.Y.;
RT "Dankookia rubra gen. nov., sp. nov., an alphaproteobacterium isolated from
RT sediment of a shallow stream.";
RL J. Microbiol. 54:420-425(2016).
CC -!- FUNCTION: Catalyzes the NADPH-dependent reduction of ketopantoate into
CC pantoic acid. {ECO:0000256|ARBA:ARBA00002919}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+);
CC Xref=Rhea:RHEA:16233, ChEBI:CHEBI:11561, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:15980, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349;
CC EC=1.1.1.169; Evidence={ECO:0000256|ARBA:ARBA00048793};
CC -!- PATHWAY: Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-
CC pantoate from 3-methyl-2-oxobutanoate: step 2/2.
CC {ECO:0000256|ARBA:ARBA00004994}.
CC -!- SIMILARITY: Belongs to the ketopantoate reductase family.
CC {ECO:0000256|ARBA:ARBA00007870}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TDH64284.1}.
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DR EMBL; SMSJ01000002; TDH64284.1; -; Genomic_DNA.
DR RefSeq; WP_133287049.1; NZ_SMSJ01000002.1.
DR AlphaFoldDB; A0A4R5QL94; -.
DR OrthoDB; 247668at2; -.
DR UniPathway; UPA00028; UER00004.
DR Proteomes; UP000295096; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0008677; F:2-dehydropantoate 2-reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0015940; P:pantothenate biosynthetic process; IEA:UniProtKB-UniPathway.
DR FunFam; 1.10.1040.10:FF:000017; 2-dehydropantoate 2-reductase; 1.
DR FunFam; 3.40.50.720:FF:000307; 2-dehydropantoate 2-reductase; 1.
DR Gene3D; 1.10.1040.10; N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR013752; KPA_reductase.
DR InterPro; IPR051402; KPR-Related.
DR InterPro; IPR013332; KPR_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR NCBIfam; NF005089; PRK06522.1-4; 1.
DR PANTHER; PTHR21708:SF45; 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR PANTHER; PTHR21708; PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Pantothenate biosynthesis {ECO:0000256|ARBA:ARBA00022655};
KW Reference proteome {ECO:0000313|Proteomes:UP000295096}.
FT DOMAIN 3..171
FT /note="Ketopantoate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02558"
FT DOMAIN 198..317
FT /note="Ketopantoate reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08546"
SQ SEQUENCE 325 AA; 34305 MW; 4F63252FBC1BA61C CRC64;
MKICVFGAGA IGGLMAARLA AKGETEVTVI ARGPHLAAMQ ANGLKLISDG QETVVRPRCV
ASAAEAGRQD YVVITLKAPA LAGAAAQMQP LIGEGTTIVS AVNGVPWWYF YKLAGPYEGR
RVESVDPTGE VGRLLPPEKV LGCIIYPAAE VSEPGVIEHT YGDRFTLGEP DGSRSDRAMA
LSAALSAAGF KAPVRPKIRD EIWVKLWGNL AFNPLSALTT ATLDVITGDA ELRAVCRQMM
LEAQAVAESL GVRFAIDVDK RIAGAAEVGA HKTSMLQDLE RGRPMEVDAL LGSVVELAGI
TEVPAPTCRT VLALLRTRAR LAGCY
//
