ID A0A4S8K9Y3_MUSBA Unreviewed; 270 AA.
AC A0A4S8K9Y3;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 05-FEB-2025, entry version 19.
DE RecName: Full=spermidine synthase {ECO:0000256|ARBA:ARBA00012455};
DE EC=2.5.1.16 {ECO:0000256|ARBA:ARBA00012455};
GN ORFNames=C4D60_Mb04t05970 {ECO:0000313|EMBL:THU71860.1};
OS Musa balbisiana (Banana).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Zingiberales; Musaceae; Musa.
OX NCBI_TaxID=52838 {ECO:0000313|EMBL:THU71860.1, ECO:0000313|Proteomes:UP000317650};
RN [1] {ECO:0000313|EMBL:THU71860.1, ECO:0000313|Proteomes:UP000317650}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DH-PKW {ECO:0000313|Proteomes:UP000317650};
RC TISSUE=Leaves {ECO:0000313|EMBL:THU71860.1};
RA Yao X.;
RT "Genome sequencing of Musa balbisiana reveals subgenome evolution and
RT function divergence in polyploid bananas.";
RL Nat. Plants 0:0-0(2019).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-
CC methyl-5'-thioadenosine + spermidine + H(+); Xref=Rhea:RHEA:12721,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:57443,
CC ChEBI:CHEBI:57834, ChEBI:CHEBI:326268; EC=2.5.1.16;
CC Evidence={ECO:0000256|ARBA:ARBA00049307};
CC -!- PATHWAY: Amine and polyamine biosynthesis; spermidine biosynthesis;
CC spermidine from putrescine: step 1/1. {ECO:0000256|ARBA:ARBA00005123}.
CC -!- SIMILARITY: Belongs to the spermidine/spermine synthase family.
CC {ECO:0000256|ARBA:ARBA00007867}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00354}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:THU71860.1}.
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DR EMBL; PYDT01000001; THU71860.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4S8K9Y3; -.
DR STRING; 52838.A0A4S8K9Y3; -.
DR Proteomes; UP000317650; Chromosome 4.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0004766; F:spermidine synthase activity; IEA:TreeGrafter.
DR GO; GO:0008295; P:spermidine biosynthetic process; IEA:TreeGrafter.
DR CDD; cd02440; AdoMet_MTases; 1.
DR FunFam; 3.40.50.150:FF:000013; Spermidine synthase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR HAMAP; MF_00198; Spermidine_synth; 1.
DR InterPro; IPR030374; PABS.
DR InterPro; IPR030373; PABS_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR001045; Spermi_synthase.
DR InterPro; IPR035246; Spermidine_synt_N.
DR PANTHER; PTHR11558:SF11; SPERMIDINE SYNTHASE; 1.
DR PANTHER; PTHR11558; SPERMIDINE/SPERMINE SYNTHASE; 1.
DR Pfam; PF17284; Spermine_synt_N; 1.
DR Pfam; PF01564; Spermine_synth; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS01330; PABS_1; 1.
DR PROSITE; PS51006; PABS_2; 2.
PE 3: Inferred from homology;
KW Polyamine biosynthesis {ECO:0000256|PROSITE-ProRule:PRU00354};
KW Reference proteome {ECO:0000313|Proteomes:UP000317650};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU00354}.
FT DOMAIN 9..46
FT /note="PABS"
FT /evidence="ECO:0000259|PROSITE:PS51006"
FT DOMAIN 47..216
FT /note="PABS"
FT /evidence="ECO:0000259|PROSITE:PS51006"
FT ACT_SITE 124
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00354"
SQ SEQUENCE 270 AA; 29567 MW; 47102FAA102AB75E CRC64;
MNGISAVIPG WFSELSPMWP GEAHSLKVEK ILFQGKSDYQ NVLVFQVLVI GGGDGGVLRE
VSRYSSVEQI DICEIDKMVV DVSKQFFPHL AVGYEDPRVT LHIGDGVAFL KDAPEGTYDA
VIVDSSDPIG PAQELFEKPF FQSVAKALRP GGVVCTQAES IWLHMHIIEG IVSACCQIFK
GSVNYAWTTV PTYPRHGVLL LIYECSGAIG FMLCSTEGPA VDFQHPVYQI DEDEASNKSK
GPLKFYNSQI HSAAFCLPSF AKRVIDSKTS
//
