ID A0A4U3MR78_9ACTN Unreviewed; 585 AA.
AC A0A4U3MR78;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 28-JAN-2026, entry version 28.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:TKK91352.1};
GN ORFNames=FDA94_00660 {ECO:0000313|EMBL:TKK91352.1};
OS Herbidospora galbida.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Streptosporangiaceae; Herbidospora.
OX NCBI_TaxID=2575442 {ECO:0000313|EMBL:TKK91352.1, ECO:0000313|Proteomes:UP000308705};
RN [1] {ECO:0000313|EMBL:TKK91352.1, ECO:0000313|Proteomes:UP000308705}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEAU-GS14 {ECO:0000313|EMBL:TKK91352.1,
RC ECO:0000313|Proteomes:UP000308705};
RA Han L.;
RT "Herbidospora sp. NEAU-GS14.nov., a novel actinomycete isolated from
RT soil.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TKK91352.1}.
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DR EMBL; SZQA01000001; TKK91352.1; -; Genomic_DNA.
DR RefSeq; WP_137245045.1; NZ_SZQA01000001.1.
DR AlphaFoldDB; A0A4U3MR78; -.
DR OrthoDB; 9803139at2; -.
DR Proteomes; UP000308705; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:TKK91352.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000308705}.
FT DOMAIN 1..167
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 585 AA; 63096 MW; 036B2B72CF4079FB CRC64;
MHVVATAGHV DHGKSTLVRA LTGMEPDRWA EERRRGLTID LGFAWRTMPS GRSLAFVDVP
GHERFVTNMM AGIGPVPAVL IVVAADEGWM PQSAEHLAVI DALGVHHGLL VVTRSDRGDA
DLAIEEARLE LAESSLADVP AVAVSSITGE GIDDLVTALD ELVASLPAPD DAAPVRLWID
RAFTIKGMGT VVTGTLPAGT VNAGDELQLS PSGRIVKIRG MESLKRKVET VTGVARVALN
LKGVDLDECR RGMALITPGR WSDTDTLDVR LRAGTSDLLP RESLLHVGSA SVSVRIRRLG
ETTARLTLEH PLPMHVGDRV ILRDPGSRRV TGLTVLDVRP PPFHGRGAAA RAADELAEWP
DPPTAHHLLA RHHYLKVADF GLMGLPPVGR TADGDWRVDL GWRVSQSQRL SALAKDHALA
NPLAPTLPVE VARQLLGLPD RRLVEALVRP PLRVEGGRIH RPADRPKLPE AIAAAVRRLE
RELESTPFQA PEAGRLAQLG LDSRAAIAAH KVGAVLRLAE GVVLPLTAEP RAVEILGDLP
QPFTASEARS ALGTSRRVVI PLLEYLDERG HTMRVDNTSR RMRPN
//
