ID A0A4U5J9E6_9EURY Unreviewed; 515 AA.
AC A0A4U5J9E6;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 18-JUN-2025, entry version 20.
DE SubName: Full=NuoM family protein {ECO:0000313|EMBL:TKR25364.1};
GN ORFNames=DM868_11430 {ECO:0000313|EMBL:TKR25364.1};
OS Natronomonas salsuginis.
OC Archaea; Methanobacteriati; Methanobacteriota; Stenosarchaea group;
OC Halobacteria; Halobacteriales; Haloarculaceae; Natronomonas.
OX NCBI_TaxID=2217661 {ECO:0000313|EMBL:TKR25364.1, ECO:0000313|Proteomes:UP000308037};
RN [1] {ECO:0000313|EMBL:TKR25364.1, ECO:0000313|Proteomes:UP000308037}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F20-122 {ECO:0000313|EMBL:TKR25364.1,
RC ECO:0000313|Proteomes:UP000308037};
RA Duran-Viseras A., Sanchez-Porro C., Ventosa A.;
RT "Natronomonas sp. F20-122 a newhaloarchaeon isolated from a saline saltern
RT of Isla Bacuta, Huelva, Spain.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the complex I subunit 4 family.
CC {ECO:0000256|ARBA:ARBA00009025}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TKR25364.1}.
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DR EMBL; QKNX01000004; TKR25364.1; -; Genomic_DNA.
DR RefSeq; WP_137277003.1; NZ_QKNX01000004.1.
DR AlphaFoldDB; A0A4U5J9E6; -.
DR OrthoDB; 19089at2157; -.
DR Proteomes; UP000308037; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR GO; GO:0048039; F:ubiquinone binding; IEA:TreeGrafter.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR GO; GO:0015990; P:electron transport coupled proton transport; IEA:TreeGrafter.
DR InterPro; IPR000260; NADH4_N.
DR InterPro; IPR010227; NADH_Q_OxRdtase_chainM/4.
DR InterPro; IPR003918; NADH_UbQ_OxRdtase.
DR InterPro; IPR001750; ND/Mrp_TM.
DR NCBIfam; TIGR01972; NDH_I_M; 1.
DR PANTHER; PTHR43507; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4; 1.
DR PANTHER; PTHR43507:SF1; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4; 1.
DR Pfam; PF01059; Oxidored_q5_N; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR PRINTS; PR01437; NUOXDRDTASE4.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000308037};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..21
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 28..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 84..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 114..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 138..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 167..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 225..249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 261..278
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 290..313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 320..342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 348..369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 389..411
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 431..451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 472..491
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 70..126
FT /note="NADH:ubiquinone oxidoreductase chain 4 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01059"
FT DOMAIN 131..432
FT /note="NADH:quinone oxidoreductase/Mrp antiporter
FT transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00361"
SQ SEQUENCE 515 AA; 55237 MW; E491046BA76F6181 CRC64;
MFVEALILLC FLAAAVVFVA PDRYAPKLAF WLSVPPLLVS LYMYLGFDGS GNALLGGEIA
YETFAEWLQF GPYAVNYHVG LDGISLPLVI LSTVLTTLAI LSAWTPIDSR QSQFYGLILF
LEGSLIGVFA ALDFILWFVF WEAVLIPMYL LIGVWGGPRR KYAAIKFFVY TNVASLVMFI
AYFGLLFGLG DAISSTSMPA AAQALRAGQL GYLGTATVGI GPETLAMVAF VAMFVGFAVK
VPIVPFHTWL PDAHVEAPTP VSVLLAGVLL KMGTYALLRF NFTMLPEQAA MLAAPIAAIA
VVSIIYGALL ALAQQDLKRV VAYSSVSSMG YVILGLVAYT VYGVGGATFQ MIAHGLISGL
LFMTVGVFYN ATHTRMIGDM SGIAGRMPVT ATVFVAGAFA YMGLPLMAGF MGELFVFIGA
FESTVLPAAP LFTAAAMFGI VIVAGYLLWA MQRSLFGPFR LETDYDLGRA PIHDLAPLLT
LVVLIIALGI APDIFFEMIR DATLDVIAFD FGGDL
//
