ID A0A4U5TUZ4_COLLU Unreviewed; 653 AA.
AC A0A4U5TUZ4;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 08-OCT-2025, entry version 23.
DE RecName: Full=YTH domain-containing family protein {ECO:0000256|RuleBase:RU369095};
GN ORFNames=D9C73_028342 {ECO:0000313|EMBL:TKS65263.1};
OS Collichthys lucidus (Big head croaker) (Sciaena lucida).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Sciaenidae; Collichthys.
OX NCBI_TaxID=240159 {ECO:0000313|EMBL:TKS65263.1, ECO:0000313|Proteomes:UP000298787};
RN [1] {ECO:0000313|EMBL:TKS65263.1, ECO:0000313|Proteomes:UP000298787}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JT15FE1705JMU {ECO:0000313|EMBL:TKS65263.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TKS65263.1};
RA Cai M., Xiao S.;
RT "Genome Assembly of Collichthys lucidus.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Specifically recognizes and binds N6-methyladenosine (m6A)-
CC containing RNAs, and regulates mRNA stability. M6A is a modification
CC present at internal sites of mRNAs and some non-coding RNAs and plays a
CC role in mRNA stability and processing. {ECO:0000256|RuleBase:RU369095}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the YTHDF family.
CC {ECO:0000256|RuleBase:RU369095}.
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DR EMBL; ML240575; TKS65263.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4U5TUZ4; -.
DR STRING; 240159.A0A4U5TUZ4; -.
DR Proteomes; UP000298787; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; IEA:TreeGrafter.
DR GO; GO:0003729; F:mRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:1990247; F:N6-methyladenosine-containing RNA reader activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:TreeGrafter.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IEA:TreeGrafter.
DR CDD; cd21134; YTH; 1.
DR FunFam; 3.10.590.10:FF:000002; YTH domain-containing protein 1 isoform X1; 1.
DR Gene3D; 3.10.590.10; ph1033 like domains; 1.
DR InterPro; IPR007275; YTH_domain.
DR InterPro; IPR045168; YTH_prot.
DR PANTHER; PTHR12357:SF3; YTH DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR12357; YTH YT521-B HOMOLOGY DOMAIN-CONTAINING; 1.
DR Pfam; PF04146; YTH; 1.
DR PROSITE; PS50882; YTH; 1.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000298787};
KW RNA-binding {ECO:0000256|RuleBase:RU369095}.
FT DOMAIN 278..415
FT /note="YTH"
FT /evidence="ECO:0000259|PROSITE:PS50882"
FT REGION 1..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 426..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 526..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..30
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..44
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..64
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..109
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..154
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..200
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..219
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..244
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..435
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..462
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..573
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 611..653
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 653 AA; 75042 MW; 81285CDAE1B60391 CRC64;
MMSCITLRLN ETSVTRKRKS ERSDSQDLKR LRPSSGHAPS RSSSTNKRAP GPPLSSSSKK
AASSPRGRHA AATSSYRHEY YEERRGRRGA REATRSRGGE EVRRRESQRG LEGLTQKLRR
TSPSPHEEDN QSEDEAAAEY GSEAGSGSSS PAASHVEEEE DDDQEEEEEE EEEEGMEEEE
EEEEEEGEKE DEEEEEEEEE YERRGGEGND YDTRSEAGDS RSASSVSFSD DGESVHSGSA
SEASGSEKKR EKLSSSVRAV RKGMENPTSK LRYILRDARF FLIKSNNHEN VSLAKAKGVW
STLPVNEKKL NAAFRSARSV VLVFSVRESG KFQGFARLAS ESHHGGSPIH WVLPAGMNAK
MLGGVFKIDW LCRRELPFTK TAHLSNPWNE HKPVKIGRDG QEIQPDIGAQ LCALFPLDES
VDVHQVARRV RHKRRTPSEP RPRGRPPQRE PGRRRPEEYD LHGRKRPRAD GPPDFNQRAG
FIQDLRNQPV DRRFSSVRRD VFLNGSYNDY MRDYHHSVGP PAPWQTLAAY PGVEQPPPHH
PPYYHHSHPP PPPHQAYHHH HHPPLPQHEA PPPRFRDKQR APQHRAFTSS PHDYDMRVDD
FLRRTQAVVS SRRERERQRE RERGGPRRER ERERARDRER ERERDKERGR YRR
//
