ID A0A4V1G7A6_9ENTR Unreviewed; 613 AA.
AC A0A4V1G7A6;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 28-JAN-2026, entry version 29.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:QCT18977.1};
GN ORFNames=FEM41_04580 {ECO:0000313|EMBL:QCT18977.1};
OS Jejubacter calystegiae.
OC Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC Enterobacterales; Enterobacteriaceae; Jejubacter.
OX NCBI_TaxID=2579935 {ECO:0000313|EMBL:QCT18977.1, ECO:0000313|Proteomes:UP000302163};
RN [1] {ECO:0000313|EMBL:QCT18977.1, ECO:0000313|Proteomes:UP000302163}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSNA2 {ECO:0000313|EMBL:QCT18977.1,
RC ECO:0000313|Proteomes:UP000302163};
RA Jiang L., Jeong J.C., Kim C.Y., Kim D.H., Kim S.W., Lee j.;
RT "Complete genome sequence of Izhakiella calystegiae KSNA2, an endophyte
RT isolated from beach morning glory (Calystegia soldanella).";
RL Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; CP040428; QCT18977.1; -; Genomic_DNA.
DR RefSeq; WP_138094866.1; NZ_CP040428.1.
DR AlphaFoldDB; A0A4V1G7A6; -.
DR KEGG; izh:FEM41_04580; -.
DR OrthoDB; 9803139at2; -.
DR Proteomes; UP000302163; Chromosome.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0035368; F:selenocysteine insertion sequence binding; IEA:TreeGrafter.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0000049; F:tRNA binding; IEA:TreeGrafter.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR GO; GO:0016259; P:selenocysteine metabolic process; IEA:TreeGrafter.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR FunFam; 1.10.10.10:FF:000350; Selenocysteine-specific translation elongation factor; 1.
DR FunFam; 2.40.30.10:FF:000080; Selenocysteine-specific translation elongation factor; 1.
DR FunFam; 3.40.50.300:FF:001064; Selenocysteine-specific translation elongation factor; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 3.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR050543; eIF2G.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR048649; WHD_1st_3rd_SelB.
DR InterPro; IPR048931; WHD_2nd_SelB_bact.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR42854; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER; 1.
DR PANTHER; PTHR42854:SF3; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF21458; WHD_1st_3rd_SelB; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF21214; WHD_2nd_SelB_bact; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 3.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:QCT18977.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000302163}.
FT DOMAIN 1..169
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 613 AA; 68328 MW; CE26F7EE766D31D4 CRC64;
MIIATAGHVD HGKTTLLQAL TGVNADRLPE EKKRGMTIDL GYAWLPQPDG EVIGFIDVPG
HEKFLANMLA GVGGIDHALL VVACDDGVMA QTREHLAILQ LTGLPSLTVA LTRADRVSEE
RIREVEQQVR ERVTSLGWPT ASLFVTAAPQ GTGIEALREH LRQLSGREHP ANRRFRLAID
RAFTVKGAGL VVTGTALSGE VSEGDTLWLT GADKPMRVRG LHAQNQPVEK ARAGQRIALN
ISGDAEKADI QRGDWLLAAR PGEPSERIIV QLSGNTALQQ WQSLHLYHAA RHITGRVSLL
EGELAELVLD TPLWLADNDR LVLRDISART TLAGARVVLL NPPRRGKRQR PFLDWLAQLA
NARDDDASFT AWLERGAVPL ATFAWARQLS PAGMAQLTQR PGLLLAGDHA LSPEVAAAWQ
QTLLKTLARY HEQHDDQPGP GRERLRRMAL PMENEALVLG LIERLRQEGL VESRRGWLHL
PDHKPGFSGE QLALWQRVEA LFGDEPWWVR DLARETGQEE QAMRQLLRMA AQQGLITAIV
KDRYYRHERI RAFANLVRDL DLERGTTCAA DFRDRLGVGR KLAIQILEYF DRIGFTRRRG
NDHLLRDNGL FDT
//
