ID   A0A4W2C6C1_BOBOX        Unreviewed;       421 AA.
AC   A0A4W2C6C1;
DT   18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2019, sequence version 1.
DT   18-JUN-2025, entry version 29.
DE   SubName: Full=GIT ArfGAP 2 {ECO:0000313|Ensembl:ENSBIXP00005045208.1};
GN   Name=GIT2 {ECO:0000313|Ensembl:ENSBIXP00000008324.1};
OS   Bos indicus x Bos taurus (Hybrid cattle).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=30522 {ECO:0000313|Ensembl:ENSBIXP00000008324.1, ECO:0000313|Proteomes:UP000314981};
RN   [1] {ECO:0000313|Proteomes:UP000314981, ECO:0000313|Proteomes:UP000429181}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Low W.Y., Tearle R., Bickhart D.M., Rosen B.D., Koren S., Rhie A.,
RA   Hiendleder S., Phillippy A.M., Smith T.P.L., Williams J.L.;
RT   "Haplotype-resolved cattle genomes.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBIXP00000008324.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2025) to UniProtKB.
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DR   Ensembl; ENSBIXT00000043575.1; ENSBIXP00000008324.1; ENSBIXG00000001621.1.
DR   Ensembl; ENSBIXT00005043262.1; ENSBIXP00005045208.1; ENSBIXG00005029102.1.
DR   GeneTree; ENSGT00940000156383; -.
DR   Proteomes; UP000314981; Chromosome 17.
DR   Proteomes; UP000429181; Chromosome 17.
DR   GO; GO:0098793; C:presynapse; IEA:GOC.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0031267; F:small GTPase binding; IEA:TreeGrafter.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007420; P:brain development; IEA:InterPro.
DR   GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR   GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:TreeGrafter.
DR   GO; GO:0036465; P:synaptic vesicle recycling; IEA:TreeGrafter.
DR   CDD; cd08847; ArfGap_GIT2; 1.
DR   FunFam; 1.25.40.20:FF:000013; ARF GTPase-activating protein GIT1 isoform 1; 1.
DR   FunFam; 1.10.220.150:FF:000003; ARF GTPase-activating protein GIT2 isoform 1; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR037278; ARFGAP/RecO.
DR   InterPro; IPR001164; ArfGAP_dom.
DR   InterPro; IPR038508; ArfGAP_dom_sf.
DR   InterPro; IPR047161; GIT-like.
DR   InterPro; IPR013724; GIT_SHD.
DR   PANTHER; PTHR46097:SF4; ARF GTPASE-ACTIVATING PROTEIN GIT2; 1.
DR   PANTHER; PTHR46097; G PROTEIN-COUPLED RECEPTOR KINASE INTERACTING ARFGAP; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF01412; ArfGap; 1.
DR   Pfam; PF08518; GIT_SHD; 2.
DR   PRINTS; PR00405; REVINTRACTNG.
DR   SMART; SM00248; ANK; 3.
DR   SMART; SM00105; ArfGap; 1.
DR   SMART; SM00555; GIT; 2.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
DR   PROSITE; PS50115; ARFGAP; 1.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000314981};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT   DOMAIN          1..124
FT                   /note="Arf-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50115"
FT   REPEAT          166..198
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REGION          376..421
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        385..403
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   421 AA;  47009 MW;  A139BFC0149BFB29 CRC64;
     MSKRLRSSEV CADCSGPDPS WASVNRGTFI CDECCSVHRS LGRHISQVRH LKHTPWPPTL
     LQMVETLYNN GANSIWEHSL LDPTSIMSGR RKANPQDKVH PNKAEFIRAK YQMLAFVHRL
     PCRDDDSVTA KDLSKQLHSS VRTGNLETCL RLLSLGAQAN FFHPEKGNTP LHVASKAGQI
     LQAELLAVYG ADPGTQDSSG KTPVDYARQG GHHELAERLV EIQYELTDRL AFYLCGRKPD
     HKNGQHFIIP QMADSSLDLS ELAKAAKKKL QSLSNHLFEE LAMDVYDEVD RRETDAVWLA
     TQNHSTLVTE TTVVPFLPVN PEYSSTRNQG RQKLARFNAH EFATLVIDIL SDAKRRQQGS
     PLSSSKDNVE LILKTISNQH SVESQDNDQP DYDSVASDED TDPEATASKA HRQKLLGKDA
     N
//