ID A0A4W2CNH6_BOBOX Unreviewed; 659 AA.
AC A0A4W2CNH6;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 18-JUN-2025, entry version 27.
DE RecName: Full=Sodium/nucleoside cotransporter {ECO:0000256|RuleBase:RU362018};
GN Name=SLC28A2 {ECO:0000313|Ensembl:ENSBIXP00000014679.1};
OS Bos indicus x Bos taurus (Hybrid cattle).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=30522 {ECO:0000313|Ensembl:ENSBIXP00000014679.1, ECO:0000313|Proteomes:UP000314981};
RN [1] {ECO:0000313|Ensembl:ENSBIXP00000014679.1, ECO:0000313|Proteomes:UP000314981}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Low W.Y., Tearle R., Bickhart D.M., Rosen B.D., Koren S., Rhie A.,
RA Hiendleder S., Phillippy A.M., Smith T.P.L., Williams J.L.;
RT "Haplotype-resolved cattle genomes.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBIXP00000014679.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the concentrative nucleoside transporter (CNT)
CC (TC 2.A.41) family. {ECO:0000256|ARBA:ARBA00009033,
CC ECO:0000256|RuleBase:RU362018}.
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DR AlphaFoldDB; A0A4W2CNH6; -.
DR SMR; A0A4W2CNH6; -.
DR STRING; 30522.A0A4W2CNH6; -.
DR Ensembl; ENSBIXT00000046656.1; ENSBIXP00000014679.1; ENSBIXG00000019310.1.
DR OMA; IMLYAMC; -.
DR Proteomes; UP000314981; Chromosome 10.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005415; F:nucleoside:sodium symporter activity; IEA:TreeGrafter.
DR GO; GO:0015211; F:purine nucleoside transmembrane transporter activity; IEA:TreeGrafter.
DR GO; GO:0001895; P:retina homeostasis; IEA:TreeGrafter.
DR InterPro; IPR008276; C_nuclsd_transpt.
DR InterPro; IPR018270; C_nuclsd_transpt_met_bac.
DR InterPro; IPR011657; CNT_C_dom.
DR InterPro; IPR002668; CNT_N_dom.
DR InterPro; IPR011642; Gate_dom.
DR NCBIfam; TIGR00804; nupC; 1.
DR PANTHER; PTHR10590; SODIUM/NUCLEOSIDE COTRANSPORTER; 1.
DR PANTHER; PTHR10590:SF11; SODIUM_NUCLEOSIDE COTRANSPORTER 2; 1.
DR Pfam; PF07670; Gate; 1.
DR Pfam; PF07662; Nucleos_tra2_C; 1.
DR Pfam; PF01773; Nucleos_tra2_N; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362018};
KW Reference proteome {ECO:0000313|Proteomes:UP000314981};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362018};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362018}; Transport {ECO:0000256|RuleBase:RU362018}.
FT TRANSMEM 80..99
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 105..124
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 171..189
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 201..219
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 257..278
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 290..313
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 333..355
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 423..441
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 527..551
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 563..587
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT DOMAIN 178..250
FT /note="Concentrative nucleoside transporter N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01773"
FT DOMAIN 259..356
FT /note="Nucleoside transporter/FeoB GTPase Gate"
FT /evidence="ECO:0000259|Pfam:PF07670"
FT DOMAIN 362..583
FT /note="Concentrative nucleoside transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07662"
FT REGION 26..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..44
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 659 AA; 72310 MW; 054F971160A16077 CRC64;
MEKTNGKEAF ALTTVETGIQ NPGLELTEEG INPEGSKRAE EQGHSLKGGL EPPTRLRRTL
QPFTRARSFC KTHAGLFKKI LLSLLCLAYA AYFLAACILD FHRALALFVL TCLVLLVLVH
RFLKRLFGEK LTRCLKPLEN SRLKFWMKWV LAGVSLIGLI LWLALDTAQR PEQLISFAGI
CMFIIILFAC SKHHSAVSWR AVLWGLGLQF VFGILVIRTD PGFNAFQWLG EQVQIFLSYT
VAGSSFVFGD VLVKDVFAFQ ALPIILFFGC VMSILYYLGL VQWVVQKIAW FLQITMGTTA
TETLAVAGNI FVGMTEAPLL IRPYLADMTL SEIHAVMTGG FATISGTVLG AFISFGIDAS
SLISASVMAA PSALALSKLV YPEVEESKFK NKEGVKLPRG KEKNVLEAAS NGATDAVGLA
SNVAANLIAF LAVLAFINAA LSWLGEMVDI QGLTFQVICS YVLRPMVFMM GVEWADCPMV
AEMVGMKFFT NEFVAYQQLS QYKNKRLSGV EEWIEGKKQW ISVRAEIITT FSLCGFANLS
SIGITLGGLT SMVPHRKSDL SKVVVSALFT GACVSLISAC VAGILYVPRG AETDCVSFLN
TSFTNRTYET YVCCRELFQS TSLNGTYNPP SFSGPWEDKE FSAIALYNCC DLYTSAVCV
//
