ID   A0A4W5NC39_9TELE        Unreviewed;       691 AA.
AC   A0A4W5NC39;
DT   18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2019, sequence version 1.
DT   28-JAN-2026, entry version 21.
DE   SubName: Full=Xenotropic and polytropic retrovirus receptor 1b {ECO:0000313|Ensembl:ENSHHUP00000049306.1};
OS   Hucho hucho (huchen).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Hucho.
OX   NCBI_TaxID=62062 {ECO:0000313|Ensembl:ENSHHUP00000049306.1, ECO:0000313|Proteomes:UP000314982};
RN   [1] {ECO:0000313|Proteomes:UP000314982}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Macqueen D.J., Gundappa M.K.;
RT   "Genome assembly of Danube salmon.";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSHHUP00000049306.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2025) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSHHUP00000049306.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2025) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SYG1 (TC 2.A.94) family.
CC       {ECO:0000256|ARBA:ARBA00009665}.
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DR   AlphaFoldDB; A0A4W5NC39; -.
DR   Ensembl; ENSHHUT00000051087.1; ENSHHUP00000049306.1; ENSHHUG00000029790.1.
DR   GeneTree; ENSGT00940000164519; -.
DR   Proteomes; UP000314982; Unassembled WGS sequence.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:TreeGrafter.
DR   GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR   GO; GO:0000822; F:inositol hexakisphosphate binding; IEA:TreeGrafter.
DR   GO; GO:0016036; P:cellular response to phosphate starvation; IEA:TreeGrafter.
DR   GO; GO:0006817; P:phosphate ion transport; IEA:TreeGrafter.
DR   CDD; cd14477; SPX_XPR1_like; 1.
DR   InterPro; IPR004342; EXS_C.
DR   InterPro; IPR004331; SPX_dom.
DR   PANTHER; PTHR10783:SF135; XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1 HOMOLOG; 1.
DR   PANTHER; PTHR10783; XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED; 1.
DR   Pfam; PF03124; EXS; 1.
DR   Pfam; PF03105; SPX; 2.
DR   PROSITE; PS51380; EXS; 1.
DR   PROSITE; PS51382; SPX; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000314982};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        236..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        269..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        314..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        347..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        475..494
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        506..527
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..176
FT                   /note="SPX"
FT                   /evidence="ECO:0000259|PROSITE:PS51382"
FT   DOMAIN          434..640
FT                   /note="EXS"
FT                   /evidence="ECO:0000259|PROSITE:PS51380"
FT   REGION          670..691
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          70..97
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   691 AA;  80385 MW;  1512DA3F46BBEF26 CRC64;
     MKFTEHLSAH ITPEWRKQYI QYEAFKDMLY SAQDQAPSIE VTDEDTVKRY YAKFEEKFFQ
     ACEKELAKIN TFYSEKLAEA QRRFATLQNE LQSSLDAQRE SSMQGLRRRR KAVFHLSQQE
     RCKHRNIKDL QLAFSEFYLS LILLQNYQNL NFTGFRKILK KHDKILETSR GADWRVAHVE
     VAPFYTCKKI TQLISETEAL VTQELEGGDR QRAMKRLRVP PLGAAQPAPA WTTFRVGLYC
     GVFLVLMVTV VITAAVVIKN ANVWPLVRIY RGGFLLIEFL FLLGINTYGW RQAGVNHVLI
     FELNPRNNLS HQHLFEIAGF LGVLWCVSIL SCLFSKSILV PMQANPLVLY GFFFLFLINP
     FKTLYYKSRF WLLKLLFRVV TAPFHRVEFA DFWLADQLNS LGVVLMDLEY LICFYSFELD
     WKQQDGLLQD SGGVCHSYSY GVRAVIQCLP AWFRFVQCLR RYRDSKRAFP HLVNAGKYST
     TFFVVTFAAL YSTHKENPAS HNEAKIFFYL LIGCSIVSSC YTLVWDLKMD WGLFDRNAGD
     NTLLREEIVY PQKAYYYCAI LEDVLLRFAW TIPLSLSTVS GIPSAADILA TILAPLEVFR
     RFVWNFFRLE NEHLNNCGEF RAVRDISVAP LNADDQTLLE QMMDQEDGVR NRLGKKNWKR
     SYSMSLRRPR LASQTKTRDT KVLIEDTDED T
//