ID A0A4W6BRA6_LATCA Unreviewed; 785 AA.
AC A0A4W6BRA6;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 28-JAN-2026, entry version 28.
DE RecName: Full=SMB domain-containing protein {ECO:0000259|PROSITE:PS50958};
GN Name=LOC108887580 {ECO:0000313|Ensembl:ENSLCAP00010001839.1};
OS Lates calcarifer (Barramundi) (Holocentrus calcarifer).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangaria incertae sedis; Centropomidae; Lates.
OX NCBI_TaxID=8187 {ECO:0000313|Ensembl:ENSLCAP00010001839.1, ECO:0000313|Proteomes:UP000314980};
RN [1] {ECO:0000313|Proteomes:UP000314980}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Sai Rama Sridatta P.;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLCAP00010001839.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSLCAP00010001839.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR AlphaFoldDB; A0A4W6BRA6; -.
DR Ensembl; ENSLCAT00010001906.1; ENSLCAP00010001839.1; ENSLCAG00010000956.1.
DR GeneTree; ENSGT00940000156034; -.
DR Proteomes; UP000314980; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0047429; F:nucleoside triphosphate diphosphatase activity; IEA:TreeGrafter.
DR GO; GO:0009143; P:nucleoside triphosphate catabolic process; IEA:TreeGrafter.
DR CDD; cd16018; Enpp; 1.
DR CDD; cd00091; NUC; 1.
DR FunFam; 4.10.410.20:FF:000001; Ectonucleotide pyrophosphatase/phosphodiesterase family member 2; 1.
DR Gene3D; 4.10.410.20; -; 2.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR Gene3D; 3.40.570.10; Extracellular Endonuclease, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR044929; DNA/RNA_non-sp_Endonuclease_sf.
DR InterPro; IPR001604; Endo_G_ENPP1-like_dom.
DR InterPro; IPR020821; ENPP1-3/EXOG-like_nuc-like.
DR InterPro; IPR044925; His-Me_finger_sf.
DR InterPro; IPR002591; Phosphodiest/P_Trfase.
DR InterPro; IPR036024; Somatomedin_B-like_dom_sf.
DR InterPro; IPR001212; Somatomedin_B_dom.
DR PANTHER; PTHR10151; ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE; 1.
DR PANTHER; PTHR10151:SF107; ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE FAMILY MEMBER 3; 1.
DR Pfam; PF01223; Endonuclease_NS; 1.
DR Pfam; PF01663; Phosphodiest; 2.
DR Pfam; PF01033; Somatomedin_B; 2.
DR SMART; SM00892; Endonuclease_NS; 1.
DR SMART; SM00477; NUC; 1.
DR SMART; SM00201; SO; 2.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR SUPFAM; SSF54060; His-Me finger endonucleases; 1.
DR SUPFAM; SSF90188; Somatomedin B domain; 2.
DR PROSITE; PS00524; SMB_1; 2.
DR PROSITE; PS50958; SMB_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000314980};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 15..58
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
FT DOMAIN 59..103
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
SQ SEQUENCE 785 AA; 88725 MW; E87936889085DCC9 CRC64;
MTHGLKKVLS VPVVPHTSCR NRCYEPYDSE TPGCRCDENC SATNSCCYDY HDICSLPTQL
WECTKLRCGE KRLIQSKCHC SDDCLSAGDC CTNYKHVCHG ENGKKCEDLA VPTCPAHFKQ
QPLLLISLDG LRAEYLQTWN TLIPVLDKLR RCGTSAPYMQ AAFPSKTFPN HYTIVTGLYP
ESNGLIDNTM YDPVFDATFS LSSPEKENPD WYLGQPVWHT AKAQGLKSGT FFWPGSDVKI
NGSYPNIYQP YNGPDFYTLY LEEPDKSGHS FGPVSGGLIE AIQGVDKIIG QLMNGLKQIG
LHRCLNIIIV ADHGMEETNC NRKEVLQQMV GDISNYYVTE GPFGRIRAKN KNTCKKPDQK
IKPYLKANLP KRLHFANSRR IEDVNVLVDP KWLFERFPGS LTFCSGGAHG YDNDVESMHA
MFVSYGPKFQ YKREIEPFSN VELYNLMCDV LQISPTDNNG THGSMNHVLR QPYYTPVPPA
EQTGPAQCPL LSLDPADSLG CSCPALVEGE KHMLFGRPRM LQPDQNYCIL YQEGFISAYS
TKALMPLWSS FTINKPVNPS VNLDPLSPVT PDCLRADVRL PASQTQRCDQ YNAAGNLTHA
FLYPPNLNIT EDQQYDALLM SNVVPMYPEF KKIWYYFHST LLKKYASVYN GINVVMGPVF
DYNYDGQYDT PEQIQQFVSG TRIPVPTHYF AVITSCRESG HPVTGCVGSL QTVSFLLPHR
PNNLENCKNT EDESNWVEDH MWFHQARVRD IEWITGLDFY QGSNQPIPEL LRVKTRPTAA
IHRKH
//
