ID A0A4W6BXE8_LATCA Unreviewed; 527 AA.
AC A0A4W6BXE8;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 08-OCT-2025, entry version 29.
DE RecName: Full=Coronin {ECO:0000256|RuleBase:RU280818};
GN Name=CORO2A {ECO:0000313|Ensembl:ENSLCAP00010004098.1};
GN Synonyms=coro2aa {ECO:0000313|RefSeq:XP_018517070.1};
OS Lates calcarifer (Barramundi) (Holocentrus calcarifer).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangaria incertae sedis; Centropomidae; Lates.
OX NCBI_TaxID=8187 {ECO:0000313|Ensembl:ENSLCAP00010004098.1, ECO:0000313|Proteomes:UP000314980};
RN [1] {ECO:0000313|Proteomes:UP000314980}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Sai Rama Sridatta P.;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:XP_018517070.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_018517070.1};
RG RefSeq;
RL Submitted (APR-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSLCAP00010004098.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAY-2025) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WD repeat coronin family.
CC {ECO:0000256|ARBA:ARBA00009482, ECO:0000256|RuleBase:RU280818}.
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DR RefSeq; XP_018517070.1; XM_018661554.2.
DR AlphaFoldDB; A0A4W6BXE8; -.
DR STRING; 8187.ENSLCAP00010004098; -.
DR Ensembl; ENSLCAT00010004205.1; ENSLCAP00010004098.1; ENSLCAG00010002088.1.
DR GeneID; 108873390; -.
DR KEGG; lcf:108873390; -.
DR CTD; 323538; -.
DR GeneTree; ENSGT00940000155598; -.
DR InParanoid; A0A4W6BXE8; -.
DR OrthoDB; 1850764at2759; -.
DR Proteomes; UP000314980; Unassembled WGS sequence.
DR Proteomes; UP000694890; Linkage group LG5.
DR GO; GO:0051015; F:actin filament binding; IEA:TreeGrafter.
DR FunFam; 2.130.10.10:FF:000053; Coronin; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR015505; Coronin.
DR InterPro; IPR015048; DUF1899.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10856; CORONIN; 1.
DR PANTHER; PTHR10856:SF2; CORONIN-2A; 1.
DR Pfam; PF08953; DUF1899; 1.
DR Pfam; PF00400; WD40; 3.
DR Pfam; PF16300; WD40_4; 1.
DR SMART; SM01166; DUF1899; 1.
DR SMART; SM01167; DUF1900; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000314980};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280818};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 10..74
FT /note="DUF1899"
FT /evidence="ECO:0000259|SMART:SM01166"
FT REPEAT 83..117
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 133..175
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 181..222
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 410..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 444..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 480..521
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 410..423
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..462
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 527 AA; 60007 MW; 2668B7F84A5F2DD5 CRC64;
MTVSKMTWRP QYRSSKFRHV FGKAATKESC YDGVPITRSV QDNNFCAVNP RFLAVITECA
GGGAFLVLSV HHRGKVDPHH PRVSGHRGNV LDIKWNPFND WCIASGSEDT TVKVWEIPPH
GVLKNLTVPW KELQGHSRRV SLIEWHPTAN NILFSTAYDY QVMIWNLDCP EQVIKNPVRT
ISHHTDVVLS MSFNTDCSLL ATTCKDRKVR LMEPRSGNLL REANCKTHKA SKVLILGNMK
MLLTTGTSRW NERQIALWDQ DDLSVPLLEE NLDGSSGVLF PFYDPDTHML YLAGKGDGNI
RYYEISSEKP YIHFLTEYRS HLPQKGMGVM PKRGLDVSSC EVFRFYKLVT IKSLIEPLSM
IVPRRSESYQ EDLYPMTAGY KPALTADEWL SGINKGPVLM SLKPGSQIAD SYSEMSKGTG
NSLDTRRSQS RPGMLQLQYI QDQMGTKDSK EDGDHADDDR SRMPVSNGED LALCSPPRTE
NELRLKFHRQ QEEIRRLREL LNQRDVRIKQ LELEIKNIKN SQPQGSL
//
