ID A0A4W6C3Y5_LATCA Unreviewed; 607 AA.
AC A0A4W6C3Y5;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 18-JUN-2025, entry version 23.
DE SubName: Full=Ligand-dependent corepressor isoform X2 {ECO:0000313|RefSeq:XP_018533217.1};
GN Name=wu:fc17b08 {ECO:0000313|Ensembl:ENSLCAP00010008456.1,
GN ECO:0000313|RefSeq:XP_018533217.1};
OS Lates calcarifer (Barramundi) (Holocentrus calcarifer).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangaria incertae sedis; Centropomidae; Lates.
OX NCBI_TaxID=8187 {ECO:0000313|Ensembl:ENSLCAP00010008456.1, ECO:0000313|Proteomes:UP000314980};
RN [1] {ECO:0000313|Proteomes:UP000314980}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Sai Rama Sridatta P.;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:XP_018533217.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_018533217.1};
RG RefSeq;
RL Submitted (MAR-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSLCAP00010008456.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00320}.
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DR RefSeq; XP_018533217.1; XM_018677701.2.
DR AlphaFoldDB; A0A4W6C3Y5; -.
DR Ensembl; ENSLCAT00010008651.1; ENSLCAP00010008456.1; ENSLCAG00010004086.1.
DR GeneID; 108884053; -.
DR GeneTree; ENSGT00940000162611; -.
DR InParanoid; A0A4W6C3Y5; -.
DR OrthoDB; 10028342at2759; -.
DR Proteomes; UP000314980; Unassembled WGS sequence.
DR Proteomes; UP000694890; Linkage group LG16_LG22.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:TreeGrafter.
DR FunFam; 1.10.10.60:FF:000019; Ligand-dependent corepressor isoform 1; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeodomain-like_sf.
DR InterPro; IPR007889; HTH_Psq.
DR PANTHER; PTHR21545:SF14; LIGAND-DEPENDENT COREPRESSOR; 1.
DR PANTHER; PTHR21545; TRANSCRIPTION FACTOR MLR1/2; 1.
DR Pfam; PF05225; HTH_psq; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50960; HTH_PSQ; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00320};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00320}; Reference proteome {ECO:0000313|Proteomes:UP000314980};
KW Transcription {ECO:0000256|ARBA:ARBA00023015};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 495..547
FT /note="HTH psq-type"
FT /evidence="ECO:0000259|PROSITE:PS50960"
FT DNA_BIND 523..543
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00320"
FT REGION 154..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 479..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 559..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..189
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..199
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 584..600
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 607 AA; 67264 MW; 3465EB970BF8A6FF CRC64;
MASQCKRQQC TIERRGFRQE LDSWRHKLIH CVGFESILEG LFGPELVEDL KLFKDLKPTA
VSDWSFDENC LFCRLRRDKV KEHLIGLSSE GLEDTPKPLL VKDQTTISRL EKQAEEFLNA
VLCKKDVPNF SDPDIPVVAR EILQRMIRQF AAEYTSKTSS PQDNCSDSQP RSDQSLPTPP
LLPGAPPSTS PAATLAGPAH NQNPVLSKLL MADQDAPLDL TIKKPPAEPS EQDGVLDLSI
KKNRYSSNPP VRSPCLSPAT ATLKGRSLRA DGQVGLLMRS LQDGRRRENI GHSTRYKPSS
SLAYSLHIKE EADLESDPES PLSHNHGSSP TDFFRNGSAS WNSKTHFGAL LKLKASGEAS
EHLKDLPKLL EAAGLLTKSL AYEKGNLQEA CMDHSLSLSH SSSFDLKIPQ VRVLASGTDP
SWDSLSSEYS GSLCENGLGK KLRSIIPRQI QKKSSRGVNS SDLEKEYWPY VTDRQALGGN
TPLDSELDLG NKQPRKKRGR YRQYNTELLE EAIVVVMGGK MSVSKAQTIY GIPHSTLEYK
VKERLGTLKN PPKKKLKLMS LAEEQGGTQY PERKELQNPQ NIVSEKRAST SEETGNDSHD
GSLSSNE
//
