ID A0A4W6CMV0_LATCA Unreviewed; 779 AA.
AC A0A4W6CMV0;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 18-JUN-2025, entry version 27.
DE SubName: Full=SIX homeobox 5 {ECO:0000313|Ensembl:ENSLCAP00010013645.1};
OS Lates calcarifer (Barramundi) (Holocentrus calcarifer).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangaria incertae sedis; Centropomidae; Lates.
OX NCBI_TaxID=8187 {ECO:0000313|Ensembl:ENSLCAP00010013645.1, ECO:0000313|Proteomes:UP000314980};
RN [1] {ECO:0000313|Proteomes:UP000314980}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Sai Rama Sridatta P.;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLCAP00010013645.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-
CC ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the SIX/Sine oculis homeobox family.
CC {ECO:0000256|ARBA:ARBA00008161}.
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DR AlphaFoldDB; A0A4W6CMV0; -.
DR STRING; 8187.ENSLCAP00010013645; -.
DR Ensembl; ENSLCAT00010013942.1; ENSLCAP00010013645.1; ENSLCAG00010006488.1.
DR GeneTree; ENSGT00940000166238; -.
DR InParanoid; A0A4W6CMV0; -.
DR Proteomes; UP000314980; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:TreeGrafter.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:TreeGrafter.
DR CDD; cd00086; homeodomain; 1.
DR FunFam; 1.10.10.60:FF:000085; SIX homeobox 5; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR001356; HD.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR009057; Homeodomain-like_sf.
DR InterPro; IPR031701; SIX1_SD.
DR PANTHER; PTHR10390; HOMEOBOX PROTEIN SIX; 1.
DR PANTHER; PTHR10390:SF65; HOMEOBOX PROTEIN SIX5; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF16878; SIX1_SD; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000314980};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 171..222
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 173..223
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 387..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..14
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..238
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..418
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 779 AA; 82482 MW; 7AEFDF41F199E8F8 CRC64;
MASLSLESAE QSENSPEEPT APVTKEEKDP VQVSEELLQS FQKSALSFST DQVSCLCEAL
LQAGNVDRLW RFLSTIPPSS ELLRGNETLL KAQALVAFHR EEFKELYAIL ESHDFHPSNH
GFLQDLYLKA RYKEAERSRG RSLGAVDKYR LRKKFPLPKT IWDGEETVYC FKEKSRNALK
ECYKSNRYPT PDEKKNLAKV TGLSLTQVSN WFKNRRQRDR TPSGTHSKSE SDGNHSTEDE
ASAMDDTPDK PEEASGSTAS IISLSAVPCS TGSQLILNGS SGFLTATQPL LLNGNSLISS
TGTGVIINGL SLGDCQTVTL SPVTASSPLI LNGAQVITKS KQVSAMEAKP SSLPAVVLSN
TTTPVSNPPS IISLPLQTRT DSGSAMDYIS VPESEGNSQT VSSSSSSLSP ASPTLSSPNG
LPSLVLKQNT QESLTLPASM SSASVDISSS AVPLSSQHGE YIVLATTGSQ MNPPKSVVSS
SSVTPQVFSL PQVVPSIQGI PVSQLVQHSS GAQVPQCPQL VPVSPLTSPA PPFQSPQAVT
AGNRLVQQQH DTSAALPEGA TTVVSIPQLN NSQLPQRMVH QLGEQTTNST PSKIQQQVIS
ITSPTQVVPV PQAKGTTPTQ LVPLSMPQLV PVSSIQTSST ISFPQVVPAS PSLSIPSAGV
PLQILTSGPG AGAVAQSPLR INQLRPIQSV GPPTSMAPGV QLLNSGIIQL PSAPPGNLLL
GGSPYLSVQQ GKLILTIPAG IQLTSLPLKP VPEQPHVSKN KNDETHSQLQ TLLCVFILI
//
