ID A0A4W6CYA1_LATCA Unreviewed; 234 AA.
AC A0A4W6CYA1;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 28-JAN-2026, entry version 30.
DE RecName: Full=Ig-like domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Lates calcarifer (Barramundi) (Holocentrus calcarifer).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangaria incertae sedis; Centropomidae; Lates.
OX NCBI_TaxID=8187 {ECO:0000313|Ensembl:ENSLCAP00010017492.1, ECO:0000313|Proteomes:UP000314980};
RN [1] {ECO:0000313|Proteomes:UP000314980}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Sai Rama Sridatta P.;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLCAP00010017492.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSLCAP00010017492.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR AlphaFoldDB; A0A4W6CYA1; -.
DR STRING; 8187.ENSLCAP00010017492; -.
DR Ensembl; ENSLCAT00010017862.1; ENSLCAP00010017492.1; ENSLCAG00010008303.1.
DR GeneTree; ENSGT00940000156195; -.
DR InParanoid; A0A4W6CYA1; -.
DR Proteomes; UP000314980; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005520; F:insulin-like growth factor binding; IEA:InterPro.
DR GO; GO:0001558; P:regulation of cell growth; IEA:InterPro.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:TreeGrafter.
DR FunFam; 2.60.40.10:FF:000291; Neuroplastin b; 1.
DR Gene3D; 4.10.40.20; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR011390; IGFBP_rP_mac25.
DR PANTHER; PTHR14186:SF20; CYSTEINE-RICH MOTOR NEURON 1 PROTEIN-LIKE; 1.
DR PANTHER; PTHR14186; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-RELATED; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF00219; IGFBP; 1.
DR SMART; SM00121; IB; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000314980};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..234
FT /note="Ig-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5021329331"
FT DOMAIN 9..93
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 140..215
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 234 AA; 25317 MW; 81BC7F0D92067916 CRC64;
MWILFFLSAL LGVLGSEEAP SGAAQQQQLQ LQCKGGVTTG VCGCCPVCAR AEGETCGGTW
DYLGKCDEGL VCVYQDAAAD KPDEERKGIC KAGECINYDL NQYQAGAMND FISLLEEKKK
NKKCDSGFVK SPLSETKLTG DAFELYCDVV GNPTPEIQWW YSEINRADSF RQLWDGARKR
RVSISTAYGA NAVSVLGISR LTLDDSGTYE CRASNDPGLL ASSVGAILPY RSGK
//
