ID A0A4W6E0Y8_LATCA Unreviewed; 908 AA.
AC A0A4W6E0Y8;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 18-JUN-2025, entry version 27.
DE SubName: Full=Transient receptor potential cation channel subfamily C member 4 {ECO:0000313|Ensembl:ENSLCAP00010030831.1};
GN Name=TRPC4 {ECO:0000313|Ensembl:ENSLCAP00010030831.1};
OS Lates calcarifer (Barramundi) (Holocentrus calcarifer).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangaria incertae sedis; Centropomidae; Lates.
OX NCBI_TaxID=8187 {ECO:0000313|Ensembl:ENSLCAP00010030831.1, ECO:0000313|Proteomes:UP000314980};
RN [1] {ECO:0000313|Proteomes:UP000314980}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Sai Rama Sridatta P.;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLCAP00010030831.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(in) = Ca(2+)(out); Xref=Rhea:RHEA:29671,
CC ChEBI:CHEBI:29108; Evidence={ECO:0000256|ARBA:ARBA00036634};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
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DR AlphaFoldDB; A0A4W6E0Y8; -.
DR Ensembl; ENSLCAT00010031523.1; ENSLCAP00010030831.1; ENSLCAG00010014475.1.
DR GeneTree; ENSGT01060000248594; -.
DR Proteomes; UP000314980; Unassembled WGS sequence.
DR GO; GO:0034703; C:cation channel complex; IEA:TreeGrafter.
DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:TreeGrafter.
DR GO; GO:0015279; F:store-operated calcium channel activity; IEA:TreeGrafter.
DR GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IEA:TreeGrafter.
DR FunFam; 1.25.40.20:FF:000023; short transient receptor potential channel 4 isoform X1; 1.
DR FunFam; 1.10.287.70:FF:000266; Transient receptor potential cation channel subfamily c member 1; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013555; TRP_dom.
DR InterPro; IPR002153; TRPC_channel.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10117:SF25; SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 4; 1.
DR PANTHER; PTHR10117; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08344; TRP_2; 1.
DR PRINTS; PR01097; TRNSRECEPTRP.
DR SMART; SM00248; ANK; 2.
DR SMART; SM01420; TRP_2; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000314980};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 330..350
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 362..383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 404..422
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 434..454
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 475..499
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 519..541
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 562..582
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 594..616
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 141..173
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 176..238
FT /note="Transient receptor ion channel"
FT /evidence="ECO:0000259|SMART:SM01420"
FT REGION 821..849
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 822..832
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 908 AA; 104166 MW; A6B1E469818AB8D8 CRC64;
MSQLYYRKTD NSSYRDRIPL RIVRAESELS ALERAYLGAV EKGDYASVKQ ALEEAEIYFR
ININCIDPLG RTALLIAIEN ENLEIIELLL SFNVYVGDAL LHAIRKEVVG AVELLLNHKK
PRGEKQVPPI LLDKQFSDFT PDITPIILAA HTNNYEIIKL LVQRGVSIPQ PHAVRCNCME
CVSSSDVDGL RHSRSRLNIY KALSSPSLIA LSSEDPFLTA FQLSWELKEL STVENEFKSE
YEELSHMCKQ FAKDLLDQTR SSRELEIILN YRDDINPLLD ENSNDLARLK LAIKYCQKEF
VAQPNCQQLL ASRWYDEFPG WRRRHWAAKL VTCFLIGLLF PLLSIFYLIS PKSRYGLFIR
KPFIKFICHT ASYLTFLFLL FLASQHIAAA ERDFQGPPPT TVEWIILPWV LGFIWTEIKQ
MWDSGFQEYI DDWWNLMDFI MNSLYLATIA LKFVAHVKYS GCKPRDSWDM WHPTLVAEAL
FAIANIFSSL RLICLFTANS HLGPLQISLG RMLLDILKFL FIYCLVLLAF ANGLNQLYFY
YVTREKDCQG IRCNVQNNAF TTLFETLQSL FWSVFGLISL YVTNVKPDHQ FTEFVGTTMF
GTYNVISLVV LLNMLIAMMN NSYQHIADHA DIEWKFARTK LWMSYFEEGG TLPSPFNIIP
SPKSVYYLIG WIKTYLFRRP SIKRLDTFET LGRRAAENVR LNHEYQEVLR NLVKRYVAAM
IRDAKTAEGL TEENFKELKQ DISSFRYEVL GMMKGKSHGR ASKVAGSTLA YPGNPFKYSP
KLLTDEPEQK LDVFDVITTT LHSGAANTTR SVCSDRLANG SVVPSSTGQI QNELPRDVSD
AGSLQRQSRL PSQRCDEIFS LSEEDSLGSS GQNQEQLQTE KLIVDVLQKV ENSLMENEHS
CKEHIKED
//
