ID   A0A4X2K0S5_VOMUR        Unreviewed;       883 AA.
AC   A0A4X2K0S5;
DT   18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2019, sequence version 1.
DT   28-JAN-2026, entry version 26.
DE   RecName: Full=Fibronectin type-III domain-containing protein {ECO:0000259|PROSITE:PS50853};
GN   Name=CSF2RB {ECO:0000313|Ensembl:ENSVURP00010005553.1};
OS   Vombatus ursinus (Common wombat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Diprotodontia; Vombatidae; Vombatus.
OX   NCBI_TaxID=29139 {ECO:0000313|Ensembl:ENSVURP00010005553.1, ECO:0000313|Proteomes:UP000314987};
RN   [1] {ECO:0000313|Proteomes:UP000314987}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Yazar S.;
RL   Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSVURP00010005553.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2025) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSVURP00010005553.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2025) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR   RefSeq; XP_027729197.1; XM_027873396.1.
DR   AlphaFoldDB; A0A4X2K0S5; -.
DR   Ensembl; ENSVURT00010006291.1; ENSVURP00010005553.1; ENSVURG00010004347.1.
DR   GeneID; 114051179; -.
DR   CTD; 1439; -.
DR   GeneTree; ENSGT00510000048963; -.
DR   OrthoDB; 8906725at2759; -.
DR   Proteomes; UP000314987; Unassembled WGS sequence.
DR   GO; GO:0009897; C:external side of plasma membrane; IEA:TreeGrafter.
DR   GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR   CDD; cd00063; FN3; 2.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR003531; Hempt_rcpt_S_F1_CS.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR048668; IL3RB_N.
DR   InterPro; IPR015321; TypeI_recpt_CBD.
DR   PANTHER; PTHR23037; CYTOKINE RECEPTOR; 1.
DR   PANTHER; PTHR23037:SF22; CYTOKINE RECEPTOR COMMON SUBUNIT BETA; 1.
DR   Pfam; PF21460; IL3Rb_N; 1.
DR   Pfam; PF09240; IL6Ra-bind; 1.
DR   SMART; SM00060; FN3; 2.
DR   SUPFAM; SSF49265; Fibronectin type III; 4.
DR   PROSITE; PS50853; FN3; 2.
DR   PROSITE; PS01355; HEMATOPO_REC_S_F1; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000314987};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..883
FT                   /note="Fibronectin type-III domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5021435603"
FT   DOMAIN          136..237
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          335..436
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   REGION          647..690
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        647..663
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   883 AA;  98867 MW;  6319F711975556F0 CRC64;
     MEVAWRGVFN ILLAVSWAST ESDIQENIPL QTLNCNNDFR TRIICQWEEV ADAQRYLNLT
     LFRQMYDNEP PKQVFCDPER NTSLPTCQFQ SCIPRTCFIH QDVFVTSQVD IFSFKADHPL
     ELQLSINLTQ NVLPPAPENL EVLENGTEGF LLSWAMPRSW TQSLQSSLVG LTFQVAYKRQ
     WESWEEASTM ESSMAQVPLG YDGLIPDNLY VARVRAKTSR GHTSLWSSEV PWESQKGDAA
     QPKNLQCFFD GHKQLSCTWE VRTEVTRSFS FGLFYKAGPG AKKECTPVHK ERKMGSPYVQ
     YRCQIHVQDP SNQSQYTVMV QSKEGKPLPS YKHIKPPTPS IKVKKAGNNY WFQWEKPQVG
     FDSEQTYEVQ YRKSTQTWEE AHRETLRIIV DMNISETSLE PATEYFARVR AMVTDKSYSG
     TWSEWSNECS WRTEKVFPPE ILGLVLVIST ILVLLGTWCC YTFGARLRTN WENKIPNPGK
     SHLFQDKNQR IWNPGNFFTV SQESPWEKEE REYSVSRMDW LDFENRSSVS PLTAVDPQDV
     CSLSSDPDPY PASITLPDED LSLSCSQKMP QPNTPVKDLD SGFAFNGPYL GLPQSHSLPN
     ISGQVGSCQA EGNKKQARGS LEYFCLPQGG QVGLVPMAKL VELGRDRVEK ETSSDHPSPR
     EEAEPCTLRE QAAPPSGEPR EEKNLSQVAA SSTGPLKLAG VSGYIAPENL VLGSEKAESL
     PPLTMPPLPC PAPESSLGLS LGETKGPLSA PSPAMLTLEG YVEVPPNMVS AEAPPENPSP
     LQVGPSAPNP MDAQQDETIT VFHPEGLIVL QQIGDYCFFP FQGQLVSPGH CPEKMAKPQD
     IQGKEPPGQP LPQVPAIQLF KAMKHQEYLV LPTWDGCRPG QVC
//