ID A0A4Y7T835_COPMI Unreviewed; 1262 AA.
AC A0A4Y7T835;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 02-APR-2025, entry version 17.
DE RecName: Full=Histone deacetylase interacting domain-containing protein {ECO:0000259|SMART:SM00761};
GN ORFNames=FA13DRAFT_1665396 {ECO:0000313|EMBL:TEB29762.1};
OS Coprinellus micaceus (Glistening ink-cap mushroom) (Coprinus micaceus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Psathyrellaceae; Coprinellus.
OX NCBI_TaxID=71717 {ECO:0000313|EMBL:TEB29762.1, ECO:0000313|Proteomes:UP000298030};
RN [1] {ECO:0000313|EMBL:TEB29762.1, ECO:0000313|Proteomes:UP000298030}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FP101781 {ECO:0000313|EMBL:TEB29762.1,
RC ECO:0000313|Proteomes:UP000298030};
RX PubMed=30886374; DOI=.1038/s41559-019-0834-1;
RA Varga T., Krizsan K., Foldi C., Dima B., Sanchez-Garcia M.,
RA Sanchez-Ramirez S., Szollosi G.J., Szarkandi J.G., Papp V., Albert L.,
RA Andreopoulos W., Angelini C., Antonin V., Barry K.W., Bougher N.L.,
RA Buchanan P., Buyck B., Bense V., Catcheside P., Chovatia M., Cooper J.,
RA Damon W., Desjardin D., Finy P., Geml J., Haridas S., Hughes K., Justo A.,
RA Karasinski D., Kautmanova I., Kiss B., Kocsube S., Kotiranta H.,
RA LaButti K.M., Lechner B.E., Liimatainen K., Lipzen A., Lukacs Z.,
RA Mihaltcheva S., Morgado L.N., Niskanen T., Noordeloos M.E., Ohm R.A.,
RA Ortiz-Santana B., Ovrebo C., Racz N., Riley R., Savchenko A., Shiryaev A.,
RA Soop K., Spirin V., Szebenyi C., Tomsovsky M., Tulloss R.E., Uehling J.,
RA Grigoriev I.V., Vagvolgyi C., Papp T., Martin F.M., Miettinen O.,
RA Hibbett D.S., Nagy L.G.;
RT "Megaphylogeny resolves global patterns of mushroom evolution.";
RL Nat. Ecol. Evol. 3:668-678(2019).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00810}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TEB29762.1}.
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DR EMBL; QPFP01000026; TEB29762.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4Y7T835; -.
DR STRING; 71717.A0A4Y7T835; -.
DR OrthoDB; 10265969at2759; -.
DR Proteomes; UP000298030; Unassembled WGS sequence.
DR GO; GO:0070822; C:Sin3-type complex; IEA:TreeGrafter.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:TreeGrafter.
DR FunFam; 1.20.1160.11:FF:000001; Paired amphipathic helix protein Sin3; 1.
DR Gene3D; 1.20.1160.11; Paired amphipathic helix; 3.
DR InterPro; IPR013194; HDAC_interact_dom.
DR InterPro; IPR003822; PAH.
DR InterPro; IPR036600; PAH_sf.
DR InterPro; IPR039774; Sin3-like.
DR InterPro; IPR031693; Sin3_C.
DR PANTHER; PTHR12346:SF0; SIN3A, ISOFORM G; 1.
DR PANTHER; PTHR12346; SIN3B-RELATED; 1.
DR Pfam; PF02671; PAH; 3.
DR Pfam; PF08295; Sin3_corepress; 1.
DR Pfam; PF16879; Sin3a_C; 1.
DR SMART; SM00761; HDAC_interact; 1.
DR SUPFAM; SSF47762; PAH2 domain; 3.
DR PROSITE; PS51477; PAH; 2.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00810}; Reference proteome {ECO:0000313|Proteomes:UP000298030};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 540..640
FT /note="Histone deacetylase interacting"
FT /evidence="ECO:0000259|SMART:SM00761"
FT REGION 1..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 356..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 873..895
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 910..937
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..21
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..47
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..58
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..96
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..389
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 921..933
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1262 AA; 141777 MW; BF6F57B28E0F9523 CRC64;
MDVDQPVPSP SKPPSPAPEP PTVEDSTVAV APPAAEPVDP PQPPLPDDPP KISHERGKTP
SVDLEQVVTS SRAPSPKSVA ARPATPTPAT AAEATPSHSR RATPMAVDEP PRTRATRSRR
QSPIPMEGSP HDRPLNVTDA LTYLDQVKLQ FNSQPDVYNQ FLDIMKEFKN DQIDTPGVIE
RVSHLFHGHP DLIQGFNTFL PAGYRIECST GTYNSNVITV TTPSGTMHST QNGTNQGQMR
WTQGNGVPTP TPRPEPMPDY GIALRARRLH LTDDLAAVPY IMGQAIEPAV QYVQKIKASC
DTETYRQFLG ILTRYHHSTE SIDEAEVSRQ ISRLFKDAPD LANDFRVFMP DKNFDIQPPR
TMTPALEAAP LKRKRKNVDK DRDREKEIMT TRSNAGSVPP SKKSKHANQD ASAVSYNPRH
IVAGPSQGIP PQAQASHPSM PPDDSNFFEH VKRHLENRDL YNEFLKVVNL FTQEYIDMAT
LVKESRHFLG DSELYKQFKD ILGWDDRRER QQNLAAQQSS VEFQKAKVVS LIERPGKINY
FEKFGSYRKV PAEEANVPCS GRDEMCRSVL NDDWVCHPTW TSEDSGFVAT KKNIYEEALH
RSEEERHEYD FHIEAITRTI AILEPITIKI AQMNVDDRTS FKLKPNLGGA WKAIHQRVIK
KIYGREAGLE VIHSMQDTPA LAIPVVLGRL KQKEEEWKRA QREWNKVWRE VDARNFAKSL
DHQAITFKVA DKRAITTKAL VNQIEAAREE QMAARASLID PLFARTRPRH QMDFVMDLSV
VQDALKLTFS FMDRTHTQVS FADRRKLEAS LRSFIPLFFT LDPVAYNSAF SLPDSNLLES
EGSESDSASV NADLEMPIPL SIPIPLAYLP PPPKVNGRAA PQNRKGGVAA PSTSLLANAG
GDLRKKLLKA EQAKSSRKTR AQNGSSPATS RPQSPALMEE ELVPEVAPVD LADGIREARQ
NPRRYIFFTN TTFYVLVRLL LVLTSRLSEF KDLSAKIAAQ DPKTRRPNPG SSIAPLAAHT
VLNTPNPSKT LFYQHLLDSV EALYNNEIEQ HAFEDQMRAV FGIQHAYKVF TTDKICGAII
KQLQIIQLDH KSKELLEILK KERSLVSPTT QDQKNNRQNT ERVLGPDENI FRIDWLADIK
TITVQLIGKD DSSFDDSEVL TGRWQSYIDS FVSADVTSGV SPSKMKLPFL KRNVPLSAKR
VQPDVASRSN LEIKVCVRTY RFFYVTNTED FLWKYRSKAG DGVFIQAAEE EERATAGVDE
ED
//
